5THU
Crystal Structure of G304A HDAC8 in complex with M344
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d5thua1 | Alpha and beta proteins (a/b) | Arginase/deacetylase | Arginase/deacetylase | Histone deacetylase, HDAC | automated matches | Human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
A | d5thua2 | Artifacts | Tags | Tags | Tags | C-terminal Tags | Human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
B | d5thub_ | Alpha and beta proteins (a/b) | Arginase/deacetylase | Arginase/deacetylase | Histone deacetylase, HDAC | automated matches | Human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | Hist_deacetyl | e5thuA1 | A: a/b three-layered sandwiches | X: HAD domain-like | H: HAD domain-related | T: Arginase/deacetylase | F: Hist_deacetyl | ECOD (1.6) |
B | Hist_deacetyl | e5thuB1 | A: a/b three-layered sandwiches | X: HAD domain-like | H: HAD domain-related | T: Arginase/deacetylase | F: Hist_deacetyl | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 3.40.800.20 | Alpha Beta | 3-Layer(aba) Sandwich | Arginase | Chain A | CATH (4.3.0) |
B | 3.40.800.20 | Alpha Beta | 3-Layer(aba) Sandwich | Arginase | Chain A | CATH (4.3.0) |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR000286 | Histone deacetylase family | Family | |
IPR023801 | Histone deacetylase domain | Domain | |
IPR003084 | Histone deacetylase | Family | |
IPR037138 | Histone deacetylase domain superfamily | Homologous Superfamily | |
IPR023696 | Ureohydrolase domain superfamily | Homologous Superfamily | |
IPR050284 | Histone deacetylase and polyamine deacetylase | Family |