5VSL
Crystal structure of viperin with bound [4Fe-4S] cluster and S-adenosylhomocysteine (SAH)
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | Radical_SAM_1 | e5vslB1 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: Radical_SAM_1 | ECOD (1.6) |
A | Radical_SAM_1 | e5vslA1 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: Radical_SAM_1 | ECOD (1.6) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF04055 | Radical SAM superfamily (Radical_SAM) | Radical SAM superfamily | Radical SAM proteins catalyse diverse reactions, including unusual methylations, isomerisation, sulphur insertion, ring formation, anaerobic oxidation and protein radical formation. | Domain | |
PF13353 | 4Fe-4S single cluster domain (Fer4_12) | 4Fe-4S single cluster domain | This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR007197 | Radical SAM | Domain | |
IPR051196 | RSAD2 and Viperin antiviral | Family | |
IPR006638 | Elp3/MiaA/NifB-like, radical SAM core domain | Domain | |
IPR013785 | Aldolase-type TIM barrel | Homologous Superfamily | |
IPR026372 | S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 | Family |