5W2I

Crystal structure of the core catalytic domain of human inositol phosphate multikinase soaked with C4-analogue of PtdIns(4,5)P2 and ADP

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	IPK	e5w2iA1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: SAICAR synthase	F: IPK	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF03770	Inositol polyphosphate kinase (IPK)	Inositol polyphosphate kinase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Inositol polyphosphate multikinase,Inositol polyphosphate multikinase	kinase activity transferase activity inositol-1,4,5-trisphosphate 3-kinase activity inositol phosphate kinase activity inositol trisphosphate kinase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding kinase activity transferase activity inositol-1,4,5-trisphosphate 3-kinase activity inositol phosphate kinase activity inositol trisphosphate kinase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding inositol tetrakisphosphate kinase activity inositol-1,3,4,5-tetrakisphosphate 6-kinase activity inositol-1,3,4,6-tetrakisphosphate 5-kinase activity inositol pentakisphosphate kinase activity inositol-1,2,3,4,6-pentakisphosphate 5-kinase activity phosphatidylinositol kinase activity lipid kinase activity 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity flavonoid binding inositol-1,4,5-trisphosphate 6-kinase activity inositol-1,4,5,6-tetrakisphosphate 3-kinase activity cation binding metal ion binding	polyol metabolic process organic hydroxy compound metabolic process alcohol metabolic process inositol phosphate metabolic process organophosphate metabolic process phosphate-containing compound metabolic process inositol trisphosphate metabolic process metabolic process cellular process small molecule metabolic process phosphorus metabolic process small molecule biosynthetic process biosynthetic process organophosphate biosynthetic process polyol metabolic process organic hydroxy compound metabolic process alcohol metabolic process inositol phosphate metabolic process organophosphate metabolic process phosphate-containing compound metabolic process inositol trisphosphate metabolic process metabolic process cellular process small molecule metabolic process phosphorus metabolic process small molecule biosynthetic process biosynthetic process organophosphate biosynthetic process inositol phosphate biosynthetic process organic hydroxy compound biosynthetic process polyol biosynthetic process alcohol biosynthetic process phosphatidylinositol metabolic process glycerophospholipid metabolic process primary metabolic process phospholipid metabolic process glycerolipid metabolic process lipid metabolic process necroptotic process programmed necrotic cell death cell death programmed cell death	cellular anatomical structure intracellular anatomical structure cytoplasm membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR038286	Inositol polyphosphate kinase superfamily	Homologous Superfamily
A	IPR005522	Inositol polyphosphate kinase	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q8NFU5	Crohn disease inflammatory bowel disease osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.