5WS3

Crystal structures of human orexin 2 receptor bound to the selective antagonist EMPA determined by serial femtosecond crystallography at SACLA

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Class A (rhodopsin) G protein-coupled receptor-like	8091147	4001858	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	G protein-coupled receptor-like	8091148	3000473	SCOP2 (2022-06-29)
A	SCOP2B Superfamily	Type B glycosyltransferase-like	8038006	3001586	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	7tm_1_1	e5ws3A1	A: alpha bundles	X: Family A G protein-coupled receptor-like (From Topology)	H: Family A G protein-coupled receptor-like (From Topology)	T: Family A G protein-coupled receptor-like	F: 7tm_1_1	ECOD (1.6)
A	Glycos_transf_1	e5ws3A2	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: Glycos_transf_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF13692	Glycosyl transferases group 1 (Glyco_trans_1_4)	Glycosyl transferases group 1	-	Domain
A	PF00001	7 transmembrane receptor (rhodopsin family) (7tm_1)	7 transmembrane receptor (rhodopsin family)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Orexin receptor type 2,GlgA glycogen synthase,Orexin receptor type 2	UDP-glycosyltransferase activity alpha-1,4-glucan glucosyltransferase (NDP-glucose donor) activity glycosyltransferase activity alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity transferase activity glucosyltransferase activity hexosyltransferase activity catalytic activity UDP-glucosyltransferase activity peptide receptor activity molecular transducer activity orexin receptor activity G protein-coupled receptor activity G protein-coupled peptide receptor activity UDP-glycosyltransferase activity alpha-1,4-glucan glucosyltransferase (NDP-glucose donor) activity glycosyltransferase activity alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity transferase activity glucosyltransferase activity hexosyltransferase activity catalytic activity UDP-glucosyltransferase activity peptide receptor activity molecular transducer activity orexin receptor activity G protein-coupled receptor activity G protein-coupled peptide receptor activity transmembrane signaling receptor activity signaling receptor activity amide binding binding peptide hormone binding hormone binding neuropeptide receptor activity peptide binding	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation cell communication G protein-coupled receptor signaling pathway cellular process signal transduction neuropeptide signaling pathway locomotion phospholipase C-activating G protein-coupled receptor signaling pathway rhythmic process cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation cell communication G protein-coupled receptor signaling pathway cellular process signal transduction neuropeptide signaling pathway locomotion phospholipase C-activating G protein-coupled receptor signaling pathway rhythmic process circadian sleep/wake cycle multicellular organismal process rhythmic behavior circadian rhythm regulation of circadian sleep/wake cycle regulation of circadian sleep/wake cycle, wakefulness regulation of circadian rhythm behavior regulation of behavior circadian behavior circadian sleep/wake cycle, wakefulness regulation of multicellular organismal process circadian sleep/wake cycle process trans-synaptic signaling synaptic signaling anterograde trans-synaptic signaling cell-cell signaling chemical synaptic transmission cellular response to endogenous stimulus cellular response to chemical stimulus response to hormone response to endogenous stimulus response to chemical cellular response to hormone stimulus inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis regulation of cytosolic calcium ion concentration cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis feeding behavior	cellular anatomical structure synapse cell junction cell periphery plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR011835	Bacterial/plant glycogen synthase	Family
A	IPR013534	Starch synthase, catalytic domain	Domain
A	IPR000276	G protein-coupled receptor, rhodopsin-like	Family
A	IPR004060	Orexin receptor 2	Family
A	IPR017452	GPCR, rhodopsin-like, 7TM	Domain
A	IPR000204	Orexin receptor family	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O43614	narcolepsy insomnia narcolepsy-cataplexy syndrome

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	G Protein-Coupled Receptors: Class A	OX₂ orexin receptor with bound antagonist EMPA

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.