Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyUbiquitin-like 8091719 3000157 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyCysteine proteinases 8091717 3001808 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyCysteine proteinases 8091717 3001808 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyPLpro Zn-binding domain-like 8091718 3002538 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AViral_protease_Ne5y3eA1 A: a+b two layersX: beta-GraspH: Ubiquitin-relatedT: Ubiquitin-likeF: Viral_protease_NECOD (1.6)
AViral_protease_Ce5y3eA2 A: a+b complex topologyX: Cysteine proteinases-likeH: Cysteine proteinases (From Topology)T: Cysteine proteinasesF: Viral_protease_CECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.10.20.540 Alpha Beta Roll Ubiquitin-like (UB roll) Papain-like viral protease, N-terminal domainCATH (4.3.0)
A1.10.8.1190 Mainly Alpha Orthogonal Bundle Helicase, Ruva Protein domain 3CATH (4.3.0)
A2.60.120.1680 Mainly Beta Sandwich Jelly Rolls CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF08715Coronavirus papain-like peptidase (CoV_peptidase)Coronavirus papain-like peptidase- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Replicase polyprotein 1a

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR022733DPUP/SUD, C-terminal, betacoronavirusDomain
IPR024358Non-structural protein NSP3, N-terminal, betacoronavirusDomain
IPR043611Coronavirus replicase NSP3, C-terminalDomain
IPR044864Non-structural protein NSP3, SUD-N (Mac2) domain, betacoronavirusDomain
IPR038123Non-structural protein NSP4, C-terminal superfamily, coronavirusHomologous Superfamily
IPR042570Non-structural protein NSP3, nucleic acid-binding domain superfamily, betacoronavirusHomologous Superfamily
IPR047566Coronavirus replicase NSP3, Y domainDomain
IPR043178Papain-like protease, thumb domain superfamily, coronavirusHomologous Superfamily
IPR043612Non-structural protein NSP4, N-terminal, coronavirusDomain
IPR038166Polyprotein cleavage domain PL2pro superfamily, betacoronavirusHomologous Superfamily
IPR044353NSP3, second ubiquitin-like (Ubl) domain, coronavirusDomain
IPR009003Peptidase S1, PA clanHomologous Superfamily
IPR013016Peptidase C16, coronavirusDomain
IPR037204Non-structural protein NSP7 superfamily, coronavirusHomologous Superfamily
IPR044374Non-structural protein 3, SUD-N macrodomain, SARS-CoVDomain
IPR044357NSP3, first ubiquitin-like (Ubl) domain, coronavirusDomain
IPR046443NSP1, globular domain, alpha/betacoronavirusDomain
IPR043610Non-structural protein 6, coronavirusDomain
IPR043477Peptidase C30, domain 3, coronavirusHomologous Superfamily
IPR018995RNA synthesis protein NSP10, coronavirusDomain
IPR043478Non-structural protein NSP3, SUD-N (Mac2) domain superfamily, betacoronavirusHomologous Superfamily
IPR038400Non-structural protein NSP3, SUD-M domain superfamily, betacoronavirusHomologous Superfamily
IPR046442NSP1, C-terminal domain, betacoronavirusDomain
IPR043615Nonstructural protein 2, N-terminal domain, coronavirusDomain
IPR043177Papain-like protease, N-terminal domain superfamily, coronavirusHomologous Superfamily
IPR014822Non-structural protein NSP9, coronavirusDomain
IPR038030NSP1 globular domain superfamily, betacoronavirusHomologous Superfamily
IPR021590NSP1, globular domain, betacoronavirusDomain
IPR024375Non-structural protein NSP3, SUD-M domain, betacoronavirusDomain
IPR044367Non-structural protein 6, betacoronavirusDomain
IPR037230Non-structural protein NSP8 superfamily, coronavirusHomologous Superfamily
IPR014828Non-structural protein NSP7, coronavirusDomain
IPR032505Non-structural protein NSP4, C-terminal, coronavirusDomain
IPR043503Papain-like viral protease, palm and finger domains, coronavirusHomologous Superfamily
IPR014829Non-structural protein NSP8, coronavirusDomain
IPR036499Non-structural protein NSP9 superfamily, coronavirusHomologous Superfamily
IPR002589Macro domainDomain
IPR047567Non-structural protein NSP3, group 2-specific marker domain, betacoronavirusDomain
IPR044389Non-structural protein 2, SARS-CoV-likeDomain
IPR008740Peptidase C30, coronavirusDomain
IPR036333RNA synthesis protein NSP10 superfamily, coronavirusHomologous Superfamily
IPR047573Non-structural protein 2, middle domain, coronavirusDomain
IPR049894Coronavirus NSP3, 3Ecto domainDomain
IPR043472Macro domain-likeHomologous Superfamily
IPR044371Non-structural protein 3, X-domain-likeDomain
IPR032592Non-structural protein NSP3, nucleic acid-binding domain, betacoronavirusDomain
IPR043613Non-structural protein 2, C-terminal domain, coronavirusDomain
IPR038083Non-structural protein NSP3A domain-like superfamilyHomologous Superfamily
IPR043504Peptidase S1, PA clan, chymotrypsin-like foldHomologous Superfamily