Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad5a8ka2 All alpha proteins Methyl-coenzyme M reductase alpha and beta chain C-terminal domain Methyl-coenzyme M reductase alpha and beta chain C-terminal domain Methyl-coenzyme M reductase alpha and beta chain C-terminal domain automated matches (Methanothermobacter wolfeii ) [TaxId: 145261 ], SCOPe (2.08)
Ad5a8ka1 Alpha and beta proteins (a+b) Ferredoxin-like Methyl-coenzyme M reductase subunits Methyl-coenzyme M reductase alpha and beta chain N-terminal domain automated matches (Methanothermobacter wolfeii ) [TaxId: 145261 ], SCOPe (2.08)
Dd5a8kd2 All alpha proteins Methyl-coenzyme M reductase alpha and beta chain C-terminal domain Methyl-coenzyme M reductase alpha and beta chain C-terminal domain Methyl-coenzyme M reductase alpha and beta chain C-terminal domain automated matches (Methanothermobacter wolfeii ) [TaxId: 145261 ], SCOPe (2.08)
Dd5a8kd1 Alpha and beta proteins (a+b) Ferredoxin-like Methyl-coenzyme M reductase subunits Methyl-coenzyme M reductase alpha and beta chain N-terminal domain automated matches (Methanothermobacter wolfeii ) [TaxId: 145261 ], SCOPe (2.08)
Bd5a8kb2 All alpha proteins Methyl-coenzyme M reductase alpha and beta chain C-terminal domain Methyl-coenzyme M reductase alpha and beta chain C-terminal domain Methyl-coenzyme M reductase alpha and beta chain C-terminal domain automated matches (Methanothermobacter wolfeii ) [TaxId: 145261 ], SCOPe (2.08)
Bd5a8kb1 Alpha and beta proteins (a+b) Ferredoxin-like Methyl-coenzyme M reductase subunits Methyl-coenzyme M reductase alpha and beta chain N-terminal domain automated matches (Methanothermobacter wolfeii ) [TaxId: 145261 ], SCOPe (2.08)
Ed5a8ke2 All alpha proteins Methyl-coenzyme M reductase alpha and beta chain C-terminal domain Methyl-coenzyme M reductase alpha and beta chain C-terminal domain Methyl-coenzyme M reductase alpha and beta chain C-terminal domain automated matches (Methanothermobacter wolfeii ) [TaxId: 145261 ], SCOPe (2.08)
Ed5a8ke1 Alpha and beta proteins (a+b) Ferredoxin-like Methyl-coenzyme M reductase subunits Methyl-coenzyme M reductase alpha and beta chain N-terminal domain automated matches (Methanothermobacter wolfeii ) [TaxId: 145261 ], SCOPe (2.08)
Cd5a8kc_ Alpha and beta proteins (a+b) Ferredoxin-like Methyl-coenzyme M reductase subunits Methyl-coenzyme M reductase gamma chain automated matches (Methanothermobacter wolfeii ) [TaxId: 145261 ], SCOPe (2.08)
Fd5a8kf_ Alpha and beta proteins (a+b) Ferredoxin-like Methyl-coenzyme M reductase subunits Methyl-coenzyme M reductase gamma chain automated matches (Methanothermobacter wolfeii ) [TaxId: 145261 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
CSCOP2B SuperfamilyMethyl-coenzyme M reductase subunits 8094305 3001305 SCOP2B (2022-06-29)
FSCOP2 FamilyMethyl-coenzyme M reductase gamma chain 8094304 4001330 SCOP2 (2022-06-29)
FSCOP2 SuperfamilyMethyl-coenzyme M reductase subunits 8094305 3001305 SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AMCR_alphae5a8kA2 A: alpha bundlesX: Methyl-coenzyme M reductase alpha and beta chain-C (From Topology)H: Methyl-coenzyme M reductase alpha and beta chain-C (From Topology)T: Methyl-coenzyme M reductase alpha and beta chain-CF: MCR_alphaECOD (1.6)
AMCR_alpha_Ne5a8kA1 A: a+b two layersX: Alpha-beta plaitsH: Methyl-coenzyme M reductase subunits (From Topology)T: Methyl-coenzyme M reductase subunitsF: MCR_alpha_NECOD (1.6)
DMCR_alphae5a8kD1 A: alpha bundlesX: Methyl-coenzyme M reductase alpha and beta chain-C (From Topology)H: Methyl-coenzyme M reductase alpha and beta chain-C (From Topology)T: Methyl-coenzyme M reductase alpha and beta chain-CF: MCR_alphaECOD (1.6)
DMCR_alpha_Ne5a8kD2 A: a+b two layersX: Alpha-beta plaitsH: Methyl-coenzyme M reductase subunits (From Topology)T: Methyl-coenzyme M reductase subunitsF: MCR_alpha_NECOD (1.6)
BMCR_betae5a8kB1 A: alpha bundlesX: Methyl-coenzyme M reductase alpha and beta chain-C (From Topology)H: Methyl-coenzyme M reductase alpha and beta chain-C (From Topology)T: Methyl-coenzyme M reductase alpha and beta chain-CF: MCR_betaECOD (1.6)
BMCR_beta_Ne5a8kB2 A: a+b two layersX: Alpha-beta plaitsH: Methyl-coenzyme M reductase subunits (From Topology)T: Methyl-coenzyme M reductase subunitsF: MCR_beta_NECOD (1.6)
EMCR_betae5a8kE1 A: alpha bundlesX: Methyl-coenzyme M reductase alpha and beta chain-C (From Topology)H: Methyl-coenzyme M reductase alpha and beta chain-C (From Topology)T: Methyl-coenzyme M reductase alpha and beta chain-CF: MCR_betaECOD (1.6)
EMCR_beta_Ne5a8kE2 A: a+b two layersX: Alpha-beta plaitsH: Methyl-coenzyme M reductase subunits (From Topology)T: Methyl-coenzyme M reductase subunitsF: MCR_beta_NECOD (1.6)
CMCR_gammae5a8kC1 A: a+b two layersX: Alpha-beta plaitsH: Methyl-coenzyme M reductase subunits (From Topology)T: Methyl-coenzyme M reductase subunitsF: MCR_gammaECOD (1.6)
FMCR_gammae5a8kF1 A: a+b two layersX: Alpha-beta plaitsH: Methyl-coenzyme M reductase subunits (From Topology)T: Methyl-coenzyme M reductase subunitsF: MCR_gammaECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, D
PF02745Methyl-coenzyme M reductase alpha subunit, N-terminal domain (MCR_alpha_N)Methyl-coenzyme M reductase alpha subunit, N-terminal domainMethyl-coenzyme M reductase (MCR) is the enzyme responsible for microbial formation of methane. It is a hexamer composed of 2 alpha (this family), 2 beta (Pfam:PF02241), and 2 gamma (Pfam:PF02240) subunits with two identical nickel porphinoid active ...Methyl-coenzyme M reductase (MCR) is the enzyme responsible for microbial formation of methane. It is a hexamer composed of 2 alpha (this family), 2 beta (Pfam:PF02241), and 2 gamma (Pfam:PF02240) subunits with two identical nickel porphinoid active sites [1]. The N-terminal domain has a ferredoxin-like fold.
Domain
A, D
PF02249Methyl-coenzyme M reductase alpha subunit, C-terminal domain (MCR_alpha)Methyl-coenzyme M reductase alpha subunit, C-terminal domainMethyl-coenzyme M reductase (MCR) is the enzyme responsible for microbial formation of methane. It is a hexamer composed of 2 alpha (this family), 2 beta (Pfam:PF02241), and 2 gamma (Pfam:PF02240) subunits with two identical nickel porphinoid active ...Methyl-coenzyme M reductase (MCR) is the enzyme responsible for microbial formation of methane. It is a hexamer composed of 2 alpha (this family), 2 beta (Pfam:PF02241), and 2 gamma (Pfam:PF02240) subunits with two identical nickel porphinoid active sites [1]. The C-terminal domain is comprised of an all-alpha multi-helical bundle.
Domain
B, E
PF02241Methyl-coenzyme M reductase beta subunit, C-terminal domain (MCR_beta)Methyl-coenzyme M reductase beta subunit, C-terminal domainMethyl-coenzyme M reductase (MCR) is the enzyme responsible for microbial formation of methane. It is a hexamer composed of 2 alpha (Pfam:PF02249), 2 beta (this family), and 2 gamma (Pfam:PF02240) subunits with two identical nickel porphinoid active ...Methyl-coenzyme M reductase (MCR) is the enzyme responsible for microbial formation of methane. It is a hexamer composed of 2 alpha (Pfam:PF02249), 2 beta (this family), and 2 gamma (Pfam:PF02240) subunits with two identical nickel porphinoid active sites [1]. The C-terminal domain of MCR beta has an all-alpha fold with buried central helix.
Domain
B, E
PF02783Methyl-coenzyme M reductase beta subunit, N-terminal domain (MCR_beta_N)Methyl-coenzyme M reductase beta subunit, N-terminal domainMethyl-coenzyme M reductase (MCR) is the enzyme responsible for microbial formation of methane. It is a hexamer composed of 2 alpha (Pfam:PF02249), 2 beta (this family), and 2 gamma (Pfam:PF02240) subunits with two identical nickel porphinoid active ...Methyl-coenzyme M reductase (MCR) is the enzyme responsible for microbial formation of methane. It is a hexamer composed of 2 alpha (Pfam:PF02249), 2 beta (this family), and 2 gamma (Pfam:PF02240) subunits with two identical nickel porphinoid active sites [1]. The N-terminal domain has an alpha/beta ferredoxin-like fold.
Domain
C, F
PF02240Methyl-coenzyme M reductase gamma subunit (MCR_gamma)Methyl-coenzyme M reductase gamma subunitMethyl-coenzyme M reductase (MCR) is the enzyme responsible for microbial formation of methane. It is a hexamer composed of 2 alpha (Pfam:PF02249), 2 beta (Pfam:PF02241), and 2 gamma (this family) subunits with two identical nickel porphinoid activ ...Methyl-coenzyme M reductase (MCR) is the enzyme responsible for microbial formation of methane. It is a hexamer composed of 2 alpha (Pfam:PF02249), 2 beta (Pfam:PF02241), and 2 gamma (this family) subunits with two identical nickel porphinoid active sites [1].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, D
METHYL-COENZYME M REDUCTASE -
B, E
METHYL-COENZYME M REDUCTASE -
C, F
METHYL-COENZYME M REDUCTASE -

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
A, D
AGM Parent Component: ARG

RESIDAA0272

PSI-MOD :  5-methyl-L-arginine MOD:00277
A, D
GL3 Parent Component: GLY

RESIDAA0272 , AA0265

PSI-MOD :  5-methyl-L-arginine MOD:00277 , 1-thioglycine (internal) MOD:00270 , 1-thioglycine (C-terminal) MOD:01623
A, D
MGN Parent Component: GLN

RESIDAA0272 , AA0265 , AA0273

PSI-MOD :  5-methyl-L-arginine MOD:00277 , 1-thioglycine (internal) MOD:00270 , 1-thioglycine (C-terminal) MOD:01623 , 2-methyl-L-glutamine MOD:00278
A, D
MHS Parent Component: HIS

RESIDAA0272 , AA0265 , AA0273 , AA0073

PSI-MOD :  5-methyl-L-arginine MOD:00277 , 1-thioglycine (internal) MOD:00270 , 1-thioglycine (C-terminal) MOD:01623 , 2-methyl-L-glutamine MOD:00278 , 3'-methyl-L-histidine MOD:00082
A, D
SMC Parent Component: CYS

RESIDAA0272 , AA0265 , AA0273 , AA0073 , AA0234

PSI-MOD :  5-methyl-L-arginine MOD:00277 , 1-thioglycine (internal) MOD:00270 , 1-thioglycine (C-terminal) MOD:01623 , 2-methyl-L-glutamine MOD:00278 , 3'-methyl-L-histidine MOD:00082 , S-methyl-L-cysteine MOD:00239