Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyFlavoproteins 8044090 3001217 SCOP2B (2022-06-29)
B [auth C]SCOP2B SuperfamilyFlavoproteins 8044090 3001217 SCOP2B (2022-06-29)
C [auth E]SCOP2B SuperfamilyFlavoproteins 8044090 3001217 SCOP2B (2022-06-29)
D [auth G]SCOP2B SuperfamilyFlavoproteins 8044090 3001217 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AFMN_rede5ea2A1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Flavoproteins/Phosphotyrosine protein phosphatases-likeT: FlavoproteinsF: FMN_redECOD (1.6)
B [auth C]FMN_rede5ea2C1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Flavoproteins/Phosphotyrosine protein phosphatases-likeT: FlavoproteinsF: FMN_redECOD (1.6)
C [auth E]FMN_rede5ea2E1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Flavoproteins/Phosphotyrosine protein phosphatases-likeT: FlavoproteinsF: FMN_redECOD (1.6)
D [auth G]FMN_rede5ea2G1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Flavoproteins/Phosphotyrosine protein phosphatases-likeT: FlavoproteinsF: FMN_redECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.40.50.360 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Flavodoxin domainCATH (4.3.0)
B [auth C]3.40.50.360 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Flavodoxin domainCATH (4.3.0)
C [auth E]3.40.50.360 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Flavodoxin domainCATH (4.3.0)
D [auth G]3.40.50.360 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Flavodoxin domainCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A,
B [auth C],
C [auth E],
D [auth G]
PF02525Flavodoxin-like fold (Flavodoxin_2)Flavodoxin-like foldThis family consists of a domain with a flavodoxin-like fold. The family includes bacterial and eukaryotic NAD(P)H dehydrogenase (quinone) EC:1.6.99.2. These enzymes catalyse the NAD(P)H-dependent two-electron reductions of quinones and protect cell ...This family consists of a domain with a flavodoxin-like fold. The family includes bacterial and eukaryotic NAD(P)H dehydrogenase (quinone) EC:1.6.99.2. These enzymes catalyse the NAD(P)H-dependent two-electron reductions of quinones and protect cells against damage by free radicals and reactive oxygen species [1]. This enzyme uses a FAD co-factor. The equation for this reaction is:- NAD(P)H + acceptor <=> NAD(P)(+) + reduced acceptor. This enzyme is also involved in the bioactivation of prodrugs used in chemotherapy [1]. The family also includes acyl carrier protein phosphodiesterase EC:3.1.4.14. This enzyme converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine residue from ACP [2]. This family is related to Pfam:PF03358 and Pfam:PF00258.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A,
B [auth C],
C [auth E],
D [auth G]
NAD(P)H dehydrogenase [quinone] 1

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A,
B [auth C],
C [auth E],
D [auth G]
PharosP15559