5FMQ

Crystal structure of the mid, cap-binding, mid-link and 627 domains from avian influenza A virus polymerase PB2 subunit bound to M7GTP H32 crystal form


Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AFlu_PB2_6the5fmqA1 A: alpha arraysX: PB2 '627' domain-related (From Homology)H: PB2 '627' domain-relatedT: Polymerase basic protein 2 (PB2) '627' domainF: Flu_PB2_6thECOD (1.6)
AFlu_PB2_4the5fmqA3 A: alpha arraysX: Helical domain in PB2 (From Topology)H: Helical domain in PB2 (From Topology)T: Helical domain in PB2F: Flu_PB2_4thECOD (1.6)
AFlu_PB2_5the5fmqA2 A: a+b three layersX: Polymerase basic protein 2 cap-binding domain (From Topology)H: Polymerase basic protein 2 cap-binding domain (From Topology)T: Polymerase basic protein 2 cap-binding domainF: Flu_PB2_5thECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00604Influenza RNA polymerase PB2 CAP binding domain (Flu_PB2_5th)Influenza RNA polymerase PB2 CAP binding domainInfluenza virus encodes a large, multidomain RNA-dependent RNA polymerase that can both transcribe and replicate the viral RNA genome. In influenza virus, the polymerase is composed of three polypeptides: PB1, PB2 and PA/P3. PB1 houses the polymerase ...Influenza virus encodes a large, multidomain RNA-dependent RNA polymerase that can both transcribe and replicate the viral RNA genome. In influenza virus, the polymerase is composed of three polypeptides: PB1, PB2 and PA/P3. PB1 houses the polymerase active site, whereas PB2 and PA/P3 contain, respectively, cap-binding [1] and endonuclease domains required for transcription initiation by cap-snatching [2]. This entry represents the CAP binding domain [2].
Domain
PF20951Influenza RNA polymerase PB2 6th domain (Flu_PB2_6th)Influenza RNA polymerase PB2 6th domainInfluenza virus encodes a large, multidomain RNA-dependent RNA polymerase that can both transcribe and replicate the viral RNA genome. In influenza virus, the polymerase is composed of three polypeptides: PB1, PB2 and PA/P3. PB1 houses the polymerase ...Influenza virus encodes a large, multidomain RNA-dependent RNA polymerase that can both transcribe and replicate the viral RNA genome. In influenza virus, the polymerase is composed of three polypeptides: PB1, PB2 and PA/P3. PB1 houses the polymerase active site, whereas PB2 and PA/P3 contain, respectively, cap-binding [1] and endonuclease domains required for transcription initiation by cap-snatching [2]. This entry represents the 6th domain of PB2.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
INFLUENZA A PB2 SUBUNIT