5HZX

Crystal structure of zebrafish MTH1 in complex with TH588

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5hzxa_	Alpha and beta proteins (a+b)	Nudix	Nudix	MutT-like	automated matches	Zebrafish (Danio rerio ) [TaxId: 7955 ],	SCOPe (2.08)
B	d5hzxb_	Alpha and beta proteins (a+b)	Nudix	Nudix	MutT-like	automated matches	Zebrafish (Danio rerio ) [TaxId: 7955 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Nudix	8058808	3000098	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Nudix	8058808	3000098	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	NUDIX_1	e5hzxA1	A: a+b two layers	X: beta-Grasp	H: Nudix (From Topology)	T: Nudix	F: NUDIX_1	ECOD (1.6)
B	NUDIX_1	e5hzxB1	A: a+b two layers	X: beta-Grasp	H: Nudix (From Topology)	T: Nudix	F: NUDIX_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.79.10	Alpha Beta	Alpha-Beta Complex	Nucleoside Triphosphate Pyrophosphohydrolase	Nucleoside Triphosphate Pyrophosphohydrolase	CATH (4.3.0)
B	3.90.79.10	Alpha Beta	Alpha-Beta Complex	Nucleoside Triphosphate Pyrophosphohydrolase	Nucleoside Triphosphate Pyrophosphohydrolase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00293	NUDIX domain (NUDIX)	NUDIX domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Nudix (Nucleoside diphosphate linked moiety X)-type motif 1	pyrophosphatase activity 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity nucleoside triphosphate diphosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphatase activity RNA binding binding organic cyclic compound binding nucleic acid binding pyrophosphatase activity 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity nucleoside triphosphate diphosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphatase activity RNA binding binding organic cyclic compound binding nucleic acid binding cation binding ion binding metal ion binding small molecule binding	nucleoside phosphate metabolic process cellular metabolic process 2'-deoxyribonucleotide metabolic process carbohydrate derivative metabolic process primary metabolic process nucleotide metabolic process deoxyribose phosphate metabolic process purine-containing compound metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process deoxyribonucleotide metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process purine deoxyribonucleotide metabolic process phosphate-containing compound metabolic process nucleoside phosphate metabolic process cellular metabolic process 2'-deoxyribonucleotide metabolic process carbohydrate derivative metabolic process primary metabolic process nucleotide metabolic process deoxyribose phosphate metabolic process purine-containing compound metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process deoxyribonucleotide metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process purine deoxyribonucleotide metabolic process phosphate-containing compound metabolic process metabolic process cellular process small molecule metabolic process phosphorus metabolic process cellular response to stimulus response to stimulus DNA metabolic process nucleic acid metabolic process cellular response to stress response to stress macromolecule metabolic process DNA protection	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle mitochondrion membrane-enclosed lumen intracellular membrane-bounded organelle mitochondrial matrix intracellular organelle lumen intracellular organelle organelle lumen organelle nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR003563	Oxidized purine nucleoside triphosphate	Family
A, B	IPR000086	NUDIX hydrolase domain	Domain
A, B	IPR015797	NUDIX hydrolase-like domain superfamily	Homologous Superfamily
A, B	IPR020084	NUDIX hydrolase, conserved site	Conserved Site
A, B	IPR020476	NUDIX hydrolase	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.