5ZHX

Crystal structure of SmgGDS-558 and farnesylated RhoA complex

External Resource: Annotation


Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
E [auth e]SCOP2B SuperfamilyRas-like P-loop GTPases 8057414 3002022 SCOP2B (2022-06-29)
F [auth f]SCOP2B SuperfamilyRas-like P-loop GTPases 8057414 3002022 SCOP2B (2022-06-29)
G [auth g]SCOP2B SuperfamilyRas-like P-loop GTPases 8057414 3002022 SCOP2B (2022-06-29)
H [auth h]SCOP2B SuperfamilyRas-like P-loop GTPases 8057414 3002022 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AArme5zhxA1 A: alpha superhelicesX: Repetitive alpha hairpinsH: ARM repeat (From Topology)T: ARM repeatF: ArmECOD (1.6)
BArme5zhxB1 A: alpha superhelicesX: Repetitive alpha hairpinsH: ARM repeat (From Topology)T: ARM repeatF: ArmECOD (1.6)
CArme5zhxC1 A: alpha superhelicesX: Repetitive alpha hairpinsH: ARM repeat (From Topology)T: ARM repeatF: ArmECOD (1.6)
DArme5zhxD1 A: alpha superhelicesX: Repetitive alpha hairpinsH: ARM repeat (From Topology)T: ARM repeatF: ArmECOD (1.6)
E [auth e]Rase5zhxe1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: RasECOD (1.6)
F [auth f]Rase5zhxf1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: RasECOD (1.6)
G [auth g]Rase5zhxg1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: RasECOD (1.6)
H [auth h]Rase5zhxh1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: RasECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
E [auth e]3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolasesCATH (utative)
F [auth f]3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolasesCATH (utative)
G [auth g]3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolasesCATH (utative)
H [auth h]3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolasesCATH (utative)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D
PF00514Armadillo/beta-catenin-like repeat (Arm)Armadillo/beta-catenin-like repeat- Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D
Rap1 GTPase-GDP dissociation stimulator 1
E [auth e],
F [auth f],
G [auth g],
H [auth h]		Transforming protein RhoA

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C, D
IPR040144Rap1 GTPase-GDP dissociation stimulator 1Family
A, B, C, D
IPR016024Armadillo-type foldHomologous Superfamily
A, B, C, D
IPR000225ArmadilloRepeat
A, B, C, D
IPR011989Armadillo-like helicalHomologous Superfamily
E [auth e],
F [auth f],
G [auth g],
H [auth h]		IPR001806Small GTPaseFamily
E [auth e],
F [auth f],
G [auth g],
H [auth h]		IPR003578Small GTPase RhoFamily
E [auth e],
F [auth f],
G [auth g],
H [auth h]		IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily
E [auth e],
F [auth f],
G [auth g],
H [auth h]		IPR005225Small GTP-binding domainDomain

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A, B, C, D
Pharos:  P52306
E [auth e],
F [auth f],
G [auth g],
H [auth h]		Pharos:  P61586