Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyNuclear receptor ligand-binding domain 8039119 3001442 SCOP2B (2022-06-29)
C [auth D]SCOP2B SuperfamilyNuclear receptor ligand-binding domain 8038695 3001442 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AHormone_recep_1e6a5yA1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recep_1ECOD (1.6)
C [auth D]Hormone_recepe6a5yD1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A1.10.565.10 Mainly Alpha Orthogonal Bundle Retinoid X Receptor Retinoid X ReceptorCATH (4.3.0)
C [auth D]1.10.565.10 Mainly Alpha Orthogonal Bundle Retinoid X Receptor Retinoid X ReceptorCATH (utative)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00104Ligand-binding domain of nuclear hormone receptor (Hormone_recep)Ligand-binding domain of nuclear hormone receptorThis all helical domain is involved in binding the hormone in these receptors.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Bile acid receptor
B,
D [auth F]
Nuclear receptor coactivator 1
C [auth D]Retinoic acid receptor RXR-alpha

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR001628Zinc finger, nuclear hormone receptor-typeDomain
IPR001728Thyroid hormone receptorFamily
IPR013088Zinc finger, NHR/GATA-typeHomologous Superfamily
IPR044114Bile acid receptor, ligand binding domainDomain
IPR050234Nuclear hormone receptor family NR1 subfamilyFamily
IPR001723Nuclear hormone receptorFamily
IPR000536Nuclear hormone receptor, ligand-binding domainDomain
IPR035500Nuclear hormone receptor-like domain superfamilyHomologous Superfamily
B,
D [auth F]
IPR010011Nuclear receptor coactivator, DUF1518Domain
B,
D [auth F]
IPR028819Nuclear receptor coactivator 1, basic helix-loop-helixDomain
B,
D [auth F]
IPR009110Nuclear receptor coactivator, interlockingHomologous Superfamily
B,
D [auth F]
IPR017426Nuclear receptor coactivatorFamily
B,
D [auth F]
IPR014935Nuclear receptor coactivator, receptor-binding domainDomain
B,
D [auth F]
IPR014920Nuclear receptor coactivator, Ncoa-type, interlockingDomain
B,
D [auth F]
IPR035965PAS domain superfamilyHomologous Superfamily
B,
D [auth F]
IPR036638Helix-loop-helix DNA-binding domain superfamilyHomologous Superfamily
B,
D [auth F]
IPR037077Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamilyHomologous Superfamily
B,
D [auth F]
IPR013767PAS foldDomain
B,
D [auth F]
IPR000014PAS domainDomain
B,
D [auth F]
IPR011598Myc-type, basic helix-loop-helix (bHLH) domainDomain
C [auth D]IPR001628Zinc finger, nuclear hormone receptor-typeDomain
C [auth D]IPR021780Nuclear/hormone receptor activator site AF-1Domain
C [auth D]IPR013088Zinc finger, NHR/GATA-typeHomologous Superfamily
C [auth D]IPR000003Retinoid X receptor/HNF4Family
C [auth D]IPR050274Nuclear hormone receptor family NR2 subfamilyFamily
C [auth D]IPR001723Nuclear hormone receptorFamily
C [auth D]IPR000536Nuclear hormone receptor, ligand-binding domainDomain
C [auth D]IPR035500Nuclear hormone receptor-like domain superfamilyHomologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
PharosQ96RI1
B,
D [auth F]
PharosQ15788
C [auth D]PharosP19793