6AWP

X-ray structure of the ts3 human serotonin transporter complexed with fluvoxamine at the central site

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SNF	e6awpA1	A: alpha complex topology	X: Sodium:neurotransmitter symporter family (SNF)-like (From Topology)	H: Sodium:neurotransmitter symporter family (SNF)-like (From Topology)	T: Sodium:neurotransmitter symporter family (SNF)-like	F: SNF	ECOD (1.6)
B	V-set_8	e6awpB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
B	C1-set_1	e6awpB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
C	C1-set_4	e6awpC2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
C	V-set	e6awpC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
C	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
B	Fab 8B6	VH-CH1	Mus musculus (house mouse)	IGHV1-2601, IGHJ201, IGHG2B*02	V-DOMAIN VH, C-DOMAIN CH1	IG	FAB-GAMMA-2B_KAPPA	IMGT (202445-0)
C	Fab 8B6	L-KAPPA	Mus musculus (house mouse)	IGKV6-1701, IGKJ101, IGKJ201, IGKC01, IGKC*02	V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA	IG	FAB-GAMMA-2B_KAPPA	IMGT (202445-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
B	Heavy Chain	IGHV1	-	sodium-dependent serotonin transporter	SAbDab (2024-11-15)
C	Light Chain	IGKV6	Kappa	sodium-dependent serotonin transporter	SAbDab (2024-11-15)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00209	Sodium:neurotransmitter symporter family (SNF)	Sodium:neurotransmitter symporter family	-	Family
B	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain
B	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	-	Domain
C	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain
C	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Sodium-dependent serotonin transporter	monoatomic cation transmembrane transporter activity monoatomic cation channel activity passive transmembrane transporter activity monoatomic ion channel activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding monoatomic cation transmembrane transporter activity monoatomic cation channel activity passive transmembrane transporter activity monoatomic ion channel activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding antiporter activity active transmembrane transporter activity secondary active transmembrane transporter activity cation binding cocaine binding ion binding organic cyclic compound binding heterocyclic compound binding small molecule binding alkali metal ion binding sodium ion binding metal ion binding nitric-oxide synthase binding enzyme binding identical protein binding monoamine transmembrane transporter activity serotonin binding amine binding syntaxin-1 binding SNARE binding syntaxin binding neurotransmitter transmembrane transporter activity cell adhesion molecule binding integrin binding signaling receptor binding monoatomic anion transmembrane transporter activity chloride transmembrane transporter activity solute:sodium symporter activity solute:monoatomic cation symporter activity organic hydroxy compound transmembrane transporter activity monoatomic anion:monoatomic cation symporter activity active monoatomic ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic anion:sodium symporter activity sodium ion transmembrane transporter activity serotonin:sodium:chloride symporter activity sodium:chloride symporter activity chloride:monoatomic cation symporter activity metal ion transmembrane transporter activity symporter activity inorganic anion transmembrane transporter activity	multicellular organismal process regulation of cellular process cellular developmental process regulation of developmental process negative regulation of biological process regulation of cell differentiation neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development negative regulation of cellular process negative regulation of cell differentiation system development multicellular organismal process regulation of cellular process cellular developmental process regulation of developmental process negative regulation of biological process regulation of cell differentiation neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development negative regulation of cellular process negative regulation of cell differentiation system development developmental process regulation of biological process negative regulation of developmental process biological regulation nervous system development generation of neurons cellular process negative regulation of neuron differentiation regulation of neuron differentiation localization transport neurotransmitter transport establishment of localization response to stimulus response to chemical response to xenobiotic stimulus regulation of biosynthetic process positive regulation of biological process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process metabolic process positive regulation of macromolecule metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular process monoamine transport import into cell cellular localization nitrogen compound transport serotonin uptake serotonin transport organic hydroxy compound transport establishment of localization in cell neurotransmitter uptake neurotransmitter reuptake regulation of tube diameter system process regulation of tube size circulatory system process vascular process in circulatory system blood vessel diameter maintenance regulation of biological quality vasoconstriction blood circulation regulation of anatomical structure size regulation of growth regulation of developmental growth developmental growth growth organ growth negative regulation of organ growth negative regulation of developmental growth negative regulation of growth regulation of organ growth regulation of multicellular organismal process negative regulation of multicellular organismal process regulation of body fluid levels wound healing homotypic cell-cell adhesion cell activation hemostasis platelet aggregation blood coagulation cell adhesion cell-cell adhesion response to stress coagulation response to wounding platelet activation behavior learning or memory nervous system process cognition memory cellular response to stimulus response to lipid response to oxygen-containing compound cellular response to oxygen-containing compound response to retinoic acid cellular response to chemical stimulus cellular response to retinoic acid cellular response to lipid response to toxic substance multi-multicellular organism process sperm ejaculation reproductive process multicellular organismal reproductive process mating behavior reproductive behavior insemination multi-organism reproductive process copulation regulation of thalamus size response to decreased oxygen levels response to hypoxia response to oxygen levels response to abiotic stimulus learning conditioned place preference associative learning regulation of localization signaling positive regulation of secretion by cell cell communication secretion by cell regulation of secretion by cell positive regulation of secretion signal release positive regulation of monoatomic ion transport monoatomic ion transport serotonin secretion positive regulation of serotonin secretion secretion regulation of transport regulation of monoatomic ion transport cell-cell signaling export from cell regulation of serotonin secretion regulation of secretion positive regulation of transport cellular response to nitrogen compound response to organophosphorus cellular response to organic cyclic compound cellular response to cGMP response to nitrogen compound response to cGMP response to purine-containing compound response to organic cyclic compound cell cycle regulation of cell cycle positive regulation of cell cycle negative regulation of neural precursor cell proliferation regulation of cerebellar granule cell precursor proliferation cell proliferation in external granule layer cell proliferation in hindbrain negative regulation of cerebellar granule cell precursor proliferation regulation of neural precursor cell proliferation head development negative regulation of cell population proliferation cell population proliferation animal organ development brain development central nervous system development regulation of cell population proliferation cerebellar granule cell precursor proliferation neural precursor cell proliferation hindbrain development rhythmic process circadian rhythm adult behavior response to alkaloid behavioral response to cocaine response to cocaine brain morphogenesis anatomical structure morphogenesis animal organ morphogenesis monoatomic ion transmembrane transport sodium ion transmembrane transport inorganic ion transmembrane transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport monoatomic cation transport sodium ion transport biological process involved in intraspecies interaction between organisms social behavior amino acid transport membrane depolarization regulation of membrane potential enteric nervous system development autonomic nervous system development negative regulation of signaling modulation of chemical synaptic transmission negative regulation of synaptic transmission, dopaminergic negative regulation of synaptic transmission negative regulation of cell communication synaptic signaling trans-synaptic signaling regulation of signaling regulation of synaptic transmission, dopaminergic chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication synaptic transmission, dopaminergic response to nutrient levels response to nutrient response to estradiol	cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane serotonergic synapse presynapse presynaptic membrane cell projection cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane serotonergic synapse presynapse presynaptic membrane cell projection neuron projection plasma membrane bounded cell projection endosome membrane membrane-bounded organelle intracellular anatomical structure endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle cytoplasm vesicle organelle membrane anchoring junction focal adhesion cell-substrate junction membrane microdomain membrane raft
B	8B6 antibody FAB heavy chain	cation binding ion binding binding metal ion binding small molecule binding	-	-
C	8B6 antibody FAB light chain	-	response to stimulus immune response immune system process	cellular anatomical structure extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000175	Sodium:neurotransmitter symporter	Family
A	IPR037272	Sodium:neurotransmitter symporter superfamily	Homologous Superfamily
A	IPR013086	Sodium:neurotransmitter symporter, serotonin, N-terminal	Domain
B	IPR003597	Immunoglobulin C1-set	Domain
B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
B	IPR013106	Immunoglobulin V-set domain	Domain
B	IPR003599	Immunoglobulin domain subtype	Domain
B	IPR007110	Immunoglobulin-like domain	Domain
B	IPR050380	Immune Recognition and Response Modulators	Family
B	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
C	IPR003597	Immunoglobulin C1-set	Domain
C	IPR050150	Immunoglobulin Variable Light Chain	Family
C	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
C	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
C	IPR013106	Immunoglobulin V-set domain	Domain
C	IPR003599	Immunoglobulin domain subtype	Domain
C	IPR007110	Immunoglobulin-like domain	Domain
C	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P31645	obsessive-compulsive disorder major depressive disorder bipolar disorder schizophrenia Sudden infant death syndrome alcohol abuse avoidant personality disorder substance abuse narcissistic personality disorder autism cocaine abuse melancholia amphetamine abuse substance withdrawal syndrome mood disorder obsessive-compulsive disorder major depressive disorder bipolar disorder schizophrenia Sudden infant death syndrome alcohol abuse avoidant personality disorder substance abuse narcissistic personality disorder autism cocaine abuse melancholia amphetamine abuse substance withdrawal syndrome mood disorder Asperger syndrome fibromyalgia pulmonary hypertension cocaine dependence depressive disorder anxiety disorder endogenous depression panic disorder generalized anxiety disorder intellectual disability post-traumatic stress disorder bulimia nervosa lung adenocarcinoma Crohn disease alcohol dependence mixed anxiety and depressive disorder non-small cell lung carcinoma female stress incontinence personality disorder premature ejaculation lung cancer Sjogren syndrome drug dependence neurotic disorder obesity disorder dysthymic disorder osteosarcoma breast cancer lung carcinoma seasonal affective disorder conduct disorder social phobia substance dependence substance-related disorder attention deficit hyperactivity disorder, inattentive type

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Solute Carrier (SLC) Transporter Superfamily	Serotonin transporter (SERT) ts2 construct with bound paroxetine at central site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.