6CZP

2.2 Angstrom Resolution Crystal Structure Oxygen-Insensitive NAD(P)H-dependent Nitroreductase NfsB from Vibrio vulnificus in Complex with FMN

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6czpa1	Alpha and beta proteins (a+b)	FMN-dependent nitroreductase-like	FMN-dependent nitroreductase-like	NADH oxidase/flavin reductase	automated matches	(Vibrio vulnificus ) [TaxId: 672 ],	SCOPe (2.08)
A	d6czpa2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Vibrio vulnificus ) [TaxId: 672 ],	SCOPe (2.08)
B	d6czpb1	Alpha and beta proteins (a+b)	FMN-dependent nitroreductase-like	FMN-dependent nitroreductase-like	NADH oxidase/flavin reductase	automated matches	(Vibrio vulnificus ) [TaxId: 672 ],	SCOPe (2.08)
B	d6czpb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Vibrio vulnificus ) [TaxId: 672 ],	SCOPe (2.08)
C	d6czpc1	Alpha and beta proteins (a+b)	FMN-dependent nitroreductase-like	FMN-dependent nitroreductase-like	NADH oxidase/flavin reductase	automated matches	(Vibrio vulnificus ) [TaxId: 672 ],	SCOPe (2.08)
C	d6czpc2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Vibrio vulnificus ) [TaxId: 672 ],	SCOPe (2.08)
D	d6czpd1	Alpha and beta proteins (a+b)	FMN-dependent nitroreductase-like	FMN-dependent nitroreductase-like	NADH oxidase/flavin reductase	automated matches	(Vibrio vulnificus ) [TaxId: 672 ],	SCOPe (2.08)
D	d6czpd2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Vibrio vulnificus ) [TaxId: 672 ],	SCOPe (2.08)
E	d6czpe1	Alpha and beta proteins (a+b)	FMN-dependent nitroreductase-like	FMN-dependent nitroreductase-like	NADH oxidase/flavin reductase	automated matches	(Vibrio vulnificus ) [TaxId: 672 ],	SCOPe (2.08)
E	d6czpe2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Vibrio vulnificus ) [TaxId: 672 ],	SCOPe (2.08)
F	d6czpf1	Alpha and beta proteins (a+b)	FMN-dependent nitroreductase-like	FMN-dependent nitroreductase-like	NADH oxidase/flavin reductase	automated matches	(Vibrio vulnificus ) [TaxId: 672 ],	SCOPe (2.08)
F	d6czpf2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Vibrio vulnificus ) [TaxId: 672 ],	SCOPe (2.08)
G	d6czpg_	Alpha and beta proteins (a+b)	FMN-dependent nitroreductase-like	FMN-dependent nitroreductase-like	NADH oxidase/flavin reductase	automated matches	(Vibrio vulnificus ) [TaxId: 672 ],	SCOPe (2.08)
H	d6czph1	Alpha and beta proteins (a+b)	FMN-dependent nitroreductase-like	FMN-dependent nitroreductase-like	NADH oxidase/flavin reductase	automated matches	(Vibrio vulnificus ) [TaxId: 672 ],	SCOPe (2.08)
H	d6czph2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Vibrio vulnificus ) [TaxId: 672 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	NADH oxidase/flavin reductase	8058730	4001599	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	FMN-dependent nitroreductase-like	8058731	3001947	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	FMN-dependent nitroreductase-like	8058731	3001947	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	FMN-dependent nitroreductase-like	8058731	3001947	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	FMN-dependent nitroreductase-like	8058731	3001947	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	FMN-dependent nitroreductase-like	8058731	3001947	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	FMN-dependent nitroreductase-like	8058731	3001947	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	FMN-dependent nitroreductase-like	8058731	3001947	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	FMN-dependent nitroreductase-like	8058731	3001947	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Nitroreductase	e6czpA1	A: a+b two layers	X: Alpha-beta plaits	H: FMN-dependent nitroreductase-like (From Topology)	T: FMN-dependent nitroreductase-like	F: Nitroreductase	ECOD (1.6)
B	Nitroreductase	e6czpB1	A: a+b two layers	X: Alpha-beta plaits	H: FMN-dependent nitroreductase-like (From Topology)	T: FMN-dependent nitroreductase-like	F: Nitroreductase	ECOD (1.6)
C	Nitroreductase	e6czpC1	A: a+b two layers	X: Alpha-beta plaits	H: FMN-dependent nitroreductase-like (From Topology)	T: FMN-dependent nitroreductase-like	F: Nitroreductase	ECOD (1.6)
D	Nitroreductase	e6czpD1	A: a+b two layers	X: Alpha-beta plaits	H: FMN-dependent nitroreductase-like (From Topology)	T: FMN-dependent nitroreductase-like	F: Nitroreductase	ECOD (1.6)
E	Nitroreductase	e6czpE1	A: a+b two layers	X: Alpha-beta plaits	H: FMN-dependent nitroreductase-like (From Topology)	T: FMN-dependent nitroreductase-like	F: Nitroreductase	ECOD (1.6)
F	Nitroreductase	e6czpF1	A: a+b two layers	X: Alpha-beta plaits	H: FMN-dependent nitroreductase-like (From Topology)	T: FMN-dependent nitroreductase-like	F: Nitroreductase	ECOD (1.6)
G	Nitroreductase	e6czpG1	A: a+b two layers	X: Alpha-beta plaits	H: FMN-dependent nitroreductase-like (From Topology)	T: FMN-dependent nitroreductase-like	F: Nitroreductase	ECOD (1.6)
H	Nitroreductase	e6czpH1	A: a+b two layers	X: Alpha-beta plaits	H: FMN-dependent nitroreductase-like (From Topology)	T: FMN-dependent nitroreductase-like	F: Nitroreductase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.109.10	Alpha Beta	3-Layer(aba) Sandwich	NADH Oxidase	NADH Oxidase	CATH (4.3.0)
B	3.40.109.10	Alpha Beta	3-Layer(aba) Sandwich	NADH Oxidase	NADH Oxidase	CATH (4.3.0)
C	3.40.109.10	Alpha Beta	3-Layer(aba) Sandwich	NADH Oxidase	NADH Oxidase	CATH (4.3.0)
D	3.40.109.10	Alpha Beta	3-Layer(aba) Sandwich	NADH Oxidase	NADH Oxidase	CATH (4.3.0)
E	3.40.109.10	Alpha Beta	3-Layer(aba) Sandwich	NADH Oxidase	NADH Oxidase	CATH (4.3.0)
F	3.40.109.10	Alpha Beta	3-Layer(aba) Sandwich	NADH Oxidase	NADH Oxidase	CATH (4.3.0)
G	3.40.109.10	Alpha Beta	3-Layer(aba) Sandwich	NADH Oxidase	NADH Oxidase	CATH (4.3.0)
H	3.40.109.10	Alpha Beta	3-Layer(aba) Sandwich	NADH Oxidase	NADH Oxidase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF00881	Nitroreductase family (Nitroreductase)	Nitroreductase family	The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	Oxygen-insensitive NAD(P)H nitroreductase	oxidoreductase activity catalytic activity binding nucleoside phosphate binding organic cyclic compound binding nucleotide binding heterocyclic compound binding small molecule binding	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR050627	Nitroreductase/BluB	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR029479	Nitroreductase	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR000415	Nitroreductase-like	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR033878	Oxygen-insensitive NAD(P)H nitroreductase NfsB-like	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.