6D06

Human ADAR2d E488Y mutant complexed with dsRNA containing an abasic site opposite the edited base

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	A_deamin	e6d06A1	A: a+b three layers	X: Cytidine deaminase-like (From Topology)	H: Cytidine deaminase-like (From Topology)	T: Cytidine deaminase-like	F: A_deamin	ECOD (1.6)
D	A_deamin	e6d06D1	A: a+b three layers	X: Cytidine deaminase-like (From Topology)	H: Cytidine deaminase-like (From Topology)	T: Cytidine deaminase-like	F: A_deamin	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, D	PF02137	Adenosine-deaminase (editase) domain (A_deamin)	Adenosine-deaminase (editase) domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D	Double-stranded RNA-specific editase 1	RNA binding double-stranded RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding double-stranded RNA adenosine deaminase activity hydrolase activity deaminase activity catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds tRNA-specific adenosine deaminase activity cation binding ion binding RNA binding double-stranded RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding double-stranded RNA adenosine deaminase activity hydrolase activity deaminase activity catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds tRNA-specific adenosine deaminase activity cation binding ion binding metal ion binding small molecule binding identical protein binding protein binding	nucleobase-containing compound metabolic process RNA modification adenosine to inosine editing base conversion or substitution editing macromolecule modification RNA metabolic process metabolic process primary metabolic process macromolecule metabolic process nucleic acid metabolic process regulation of cellular process regulation of catalytic activity negative regulation of biological process negative regulation of catalytic activity nucleobase-containing compound metabolic process RNA modification adenosine to inosine editing base conversion or substitution editing macromolecule modification RNA metabolic process metabolic process primary metabolic process macromolecule metabolic process nucleic acid metabolic process regulation of cellular process regulation of catalytic activity negative regulation of biological process negative regulation of catalytic activity regulation of transferase activity negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of kinase activity negative regulation of transferase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process phosphorus metabolic process protein modification process negative regulation of protein metabolic process regulation of biological process protein phosphorylation phosphorylation cellular metabolic process regulation of protein metabolic process negative regulation of metabolic process regulation of cellular metabolic process regulation of molecular function regulation of kinase activity negative regulation of protein phosphorylation regulation of phosphorus metabolic process regulation of metabolic process regulation of protein modification process regulation of protein phosphorylation negative regulation of phosphate metabolic process negative regulation of cellular process protein metabolic process negative regulation of macromolecule metabolic process negative regulation of protein kinase activity by regulation of protein phosphorylation biological regulation negative regulation of molecular function negative regulation of protein kinase activity regulation of protein kinase activity regulation of macromolecule metabolic process negative regulation of phosphorus metabolic process regulation of phosphorylation cellular process negative regulation of phosphorylation neuron apoptotic process apoptotic process motor neuron apoptotic process cell death programmed cell death developmental process multicellular organismal process cranial nerve morphogenesis parasympathetic nervous system development nervous system development multicellular organism development anatomical structure morphogenesis nerve development cranial nerve development central nervous system development preganglionic parasympathetic fiber development anatomical structure development facial nerve morphogenesis autonomic nervous system development facial nerve development system development biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus animal organ development tissue development muscle tissue morphogenesis muscle structure development tissue morphogenesis animal organ morphogenesis muscle organ development muscle organ morphogenesis cellular biosynthetic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process RNA biosynthetic process nucleic acid biosynthetic process biosynthetic process RNA processing mRNA processing mRNA metabolic process trans-synaptic signaling signaling cell-cell signaling chemical synaptic transmission cell communication synaptic signaling anterograde trans-synaptic signaling neuromuscular synaptic transmission hypoglossal nerve development hypoglossal nerve morphogenesis negative regulation of locomotion regulation of cell motility regulation of locomotion regulation of cell migration negative regulation of cell motility cell migration cell motility negative regulation of cell migration locomotion negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation positive regulation of viral genome replication positive regulation of viral process positive regulation of biological process viral life cycle regulation of viral process regulation of viral life cycle viral genome replication viral process regulation of viral genome replication axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development central nervous system neuron development neuron projection development cell morphogenesis cellular component organization neurogenesis central nervous system neuron differentiation cell projection morphogenesis spinal cord development neuron differentiation neuron projection morphogenesis cell differentiation spinal cord ventral commissure morphogenesis cellular component organization or biogenesis central nervous system projection neuron axonogenesis central nervous system neuron axonogenesis plasma membrane bounded cell projection organization axon development cell morphogenesis involved in neuron differentiation generation of neurons neuron development system process nervous system process neuromuscular process neuromuscular process controlling posture behavior motor behavior cell cycle regulation of cell cycle multicellular organism growth developmental growth growth innervation defense response to virus response to virus	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle cytoplasm cytosol nucleoplasm synapse cell junction
B	RNA (5'-R(GPCPUPCPGPCPGPAPUPGPCPUP(8AZ)PGPAPGPGPGPCPUPCPUP*G)-3')	-	-	-
C	RNA (5'-R(CPAPGPAPGPCPCPCPCPCPNPAPGPCPAPUPCPGPCPGPAPGP*C)-3')	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D	IPR002466	Adenosine deaminase/editase	Domain
A, D	IPR008996	Cytokine IL1/FGF	Homologous Superfamily
A, D	IPR044459	ADAR2, second double-stranded RNA binding domain	Domain
A, D	IPR044458	ADAR2, first double-stranded RNA binding domain	Domain
A, D	IPR014720	Double-stranded RNA-binding domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, D	Pharos: P78563	polycystic ovary syndrome non-small cell lung carcinoma ovarian cancer primitive neuroectodermal tumor Sclerocystic Ovaries amyotrophic lateral sclerosis atypical teratoid rhabdoid tumor dermatomyositis glioblastoma lung adenocarcinoma lymphoplasmacytic lymphoma medulloblastoma oligodendroglioma pilocytic astrocytoma tuberculosis polycystic ovary syndrome non-small cell lung carcinoma ovarian cancer primitive neuroectodermal tumor Sclerocystic Ovaries amyotrophic lateral sclerosis atypical teratoid rhabdoid tumor dermatomyositis glioblastoma lung adenocarcinoma lymphoplasmacytic lymphoma medulloblastoma oligodendroglioma pilocytic astrocytoma tuberculosis astrocytic tumor bipolar disorder endogenous depression juvenile dermatomyositis lung cancer malignant ependymoma myopathy osteosarcoma schizophrenia attention deficit hyperactivity disorder, inattentive type cystic fibrosis gastroesophageal reflux disease large cell medulloblastoma lung carcinoma malignant glioma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.