6DC5

RSV prefusion F in complex with AM22 Fab

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D [auth B]	V-set_8	e6dc5B2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
D [auth B]	C1-set_1	e6dc5B1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
F [auth E]	V-set_8	e6dc5E1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
F [auth E]	C1-set_1	e6dc5E2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
H	V-set_8	e6dc5H1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
H	C1-set_1	e6dc5H2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
E [auth C]	C1-set_4	e6dc5C1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
E [auth C]	V-set	e6dc5C2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
G [auth F]	C1-set_4	e6dc5F1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
G [auth F]	V-set	e6dc5F2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
I	C1-set_4	e6dc5I1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
I	V-set	e6dc5I2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
A	Fusion_gly	e6dc5A1	A: a+b complex topology	X: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	H: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	T: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein	F: Fusion_gly	ECOD (1.6)
B [auth D]	Fusion_gly	e6dc5D1	A: a+b complex topology	X: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	H: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	T: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein	F: Fusion_gly	ECOD (1.6)
C [auth G]	Fusion_gly	e6dc5G1	A: a+b complex topology	X: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	H: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	T: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein	F: Fusion_gly	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
D [auth B]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)
F [auth E]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)
H	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)
E [auth C]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)
G [auth F]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)
I	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
D [auth B], F [auth E], H	Fab AM22	VH-CH1	Homo sapiens (human)	IGHV1-2401, IGHJ401, IGHJ402, IGHJ403, IGHG101, IGHG102, IGHG104, IGHG105, IGHG112, IGHG114, IGHG113, IGHG109, IGHG110, IGHG107, IGHG1*11	V-DOMAIN VH, C-DOMAIN CH1	IG	FAB-GAMMA-1_KAPPA	IMGT (202444-0)
E [auth C], G [auth F], I	Fab AM22	L-KAPPA	Homo sapiens (human)	IGKV3-1101, IGKV3D-1103, IGKJ301, IGKC01	V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA	IG	FAB-GAMMA-1_KAPPA	IMGT (202444-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
D [auth B], F [auth E], H	Heavy Chain	IGHV1	-	rsv fusion glycoprotein	SAbDab (2024-11-08)
E [auth C], G [auth F], I	Light Chain	IGKV3	Kappa	rsv fusion glycoprotein	SAbDab (2024-11-08)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
D [auth B], F [auth E], H	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain
D [auth B], F [auth E], H	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	-	Domain
E [auth C], G [auth F], I	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain
E [auth C], G [auth F], I	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	-	Domain
A, B [auth D], C [auth G]	PF00523	Fusion glycoprotein F0 (Fusion_gly)	Fusion glycoprotein F0	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
D [auth B], F [auth E], H	Fab AM22 heavy chain	-	response to stimulus immune response immune system process adaptive immune response	cell periphery plasma membrane membrane cellular anatomical entity protein-containing complex immunoglobulin complex
E [auth C], G [auth F], I	Fab AM22 light chain	cation binding ion binding binding metal ion binding small molecule binding	response to stimulus immune response immune system process	extracellular region extracellular space cellular anatomical entity
A, B [auth D], C [auth G]	RSV fusion glycoprotein	identical protein binding protein binding binding	membrane organization cellular component organization membrane fusion fusion of virus membrane with host plasma membrane viral process cellular process cellular component organization or biogenesis membrane fusion involved in viral entry into host cell virion attachment to host cell biological process involved in interspecies interaction between organisms receptor-mediated virion attachment to host cell adhesion of symbiont to host cell entry receptor-mediated virion attachment to host cell viral life cycle membrane organization cellular component organization membrane fusion fusion of virus membrane with host plasma membrane viral process cellular process cellular component organization or biogenesis membrane fusion involved in viral entry into host cell virion attachment to host cell biological process involved in interspecies interaction between organisms receptor-mediated virion attachment to host cell adhesion of symbiont to host cell entry receptor-mediated virion attachment to host cell viral life cycle adhesion of symbiont to host biological process involved in interaction with host biological process involved in symbiotic interaction symbiont entry into host cell symbiont entry into host positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization regulation of syncytium formation by plasma membrane fusion regulation of developmental process positive regulation of biological process cell-cell fusion modulation by virus of host process modulation by virus of syncytium formation via plasma membrane fusion positive regulation of developmental process symbiont-mediated perturbation of host process anatomical structure development positive regulation of syncytium formation by virus syncytium formation induction by virus of host cell-cell fusion modulation of process of another organism positive regulation of cellular process modulation by virus of host cellular process developmental process regulation of biological process biological regulation positive regulation of syncytium formation by plasma membrane fusion syncytium formation by plasma membrane fusion anatomical structure morphogenesis anatomical structure formation involved in morphogenesis	cell periphery plasma membrane membrane cellular anatomical entity virion component viral membrane viral envelope host cell plasma membrane host cellular component host cell part host cell membrane virion membrane host intracellular part host cell Golgi membrane cell periphery plasma membrane membrane cellular anatomical entity virion component viral membrane viral envelope host cell plasma membrane host cellular component host cell part host cell membrane virion membrane host intracellular part host cell Golgi membrane host cell Golgi apparatus host cell cytoplasm part host cell cytoplasm host cell endomembrane system host intracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
D [auth B], F [auth E], H	IPR003597	Immunoglobulin C1-set	Domain
D [auth B], F [auth E], H	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
D [auth B], F [auth E], H	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
D [auth B], F [auth E], H	IPR013106	Immunoglobulin V-set domain	Domain
D [auth B], F [auth E], H	IPR003599	Immunoglobulin domain subtype	Domain
D [auth B], F [auth E], H	IPR007110	Immunoglobulin-like domain	Domain
D [auth B], F [auth E], H	IPR050380	Immune Recognition and Response Modulators	Family
D [auth B], F [auth E], H	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
E [auth C], G [auth F], I	IPR003597	Immunoglobulin C1-set	Domain
E [auth C], G [auth F], I	IPR050150	Immunoglobulin Variable Light Chain	Family
E [auth C], G [auth F], I	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
E [auth C], G [auth F], I	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
E [auth C], G [auth F], I	IPR013106	Immunoglobulin V-set domain	Domain
E [auth C], G [auth F], I	IPR003599	Immunoglobulin domain subtype	Domain
E [auth C], G [auth F], I	IPR007110	Immunoglobulin-like domain	Domain
E [auth C], G [auth F], I	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
A, B [auth D], C [auth G]	IPR012473	Fibritin C-terminal	Domain
A, B [auth D], C [auth G]	IPR000776	Precursor fusion glycoprotein F0, Paramyxoviridae	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.