Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyRas-like P-loop GTPases 8056779 3002022 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyTransducin (heterotrimeric G protein), gamma chain 8070798 3001771 SCOP2B (2022-06-29)
E [auth R]SCOP2B SuperfamilyG protein-coupled receptor-like 8091218 3000473 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ARase6ddeA1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: RasECOD (1.6)
CG-gammae6ddeC1 A: extended segmentsX: Transducin (heterotrimeric G protein), gamma chain (From Topology)H: Transducin (heterotrimeric G protein), gamma chain (From Topology)T: Transducin (heterotrimeric G protein), gamma chainF: G-gammaECOD (1.6)
BANAPC4_WD40_3e6ddeB1 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: ANAPC4_WD40_3ECOD (1.6)
D [auth E]V-sete6ddeE1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-setECOD (1.6)
D [auth E]V-set_12e6ddeE2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_12ECOD (1.6)
E [auth R]7tm_1_1e6ddeR1 A: alpha bundlesX: Family A G protein-coupled receptor-like (From Topology)H: Family A G protein-coupled receptor-like (From Topology)T: Family A G protein-coupled receptor-likeF: 7tm_1_1ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00503G-protein alpha subunit (G-alpha)G-protein alpha subunitG proteins couple receptors of extracellular signals to intracellular signaling pathways. The G protein alpha subunit binds guanyl nucleotide and is a weak GTPase. A set of residues that are unique to G-alpha as compared to its ancestor the Arf-like ...G proteins couple receptors of extracellular signals to intracellular signaling pathways. The G protein alpha subunit binds guanyl nucleotide and is a weak GTPase. A set of residues that are unique to G-alpha as compared to its ancestor the Arf-like family form a ring of residues centered on the nucleotide binding site [3]. A Ggamma is found fused to an inactive Galpha in the Dictyostelium protein gbqA [3].
Domain
PF00400WD domain, G-beta repeat (WD40)WD domain, G-beta repeat- Repeat
E [auth R]PF000017 transmembrane receptor (rhodopsin family) (7tm_1)7 transmembrane receptor (rhodopsin family)- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Guanine nucleotide-binding protein G(i) subunit alpha-1
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
D [auth E]scFv16---
E [auth R]Mu-type opioid receptor
F [auth D]DAMGO---

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
PharosP63096
PharosP59768
PharosP62873

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
F [auth D]DAL RESIDAA0111 , AA0191

PSI-MOD :  meso-lanthionine MOD:00120 , D-alanine (Ala) MOD:00198 , D-alanine (Ser) MOD:00858 , D-alanine MOD:00862
F [auth D]ETA RESIDAA0111 , AA0191

F [auth D]MEA Parent Component: PHE

RESIDAA0111 , AA0191 , AA0065

PSI-MOD :  meso-lanthionine MOD:00120 , D-alanine (Ala) MOD:00198 , D-alanine (Ser) MOD:00858 , D-alanine MOD:00862 , N-methyl-L-phenylalanine MOD:00074