6EAF

CRYSTAL STRUCTURE OF HUMAN RESPIRATORY SYNCYTIAL VIRUS FUSION GLYCOPROTEIN INHIBITOR ESCAPE VARIANT G143S STABILIZED IN THE PREFUSION STATE

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Fusion_gly	e6eafA1	A: a+b complex topology	X: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	H: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	T: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein	F: Fusion_gly	ECOD (1.6)
B	Fusion_gly	e6eafB1	A: a+b complex topology	X: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	H: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	T: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein	F: Fusion_gly	ECOD (1.6)
C	Fusion_gly	e6eafC1	A: a+b complex topology	X: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	H: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	T: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein	F: Fusion_gly	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF00523	Fusion glycoprotein F0 (Fusion_gly)	Fusion glycoprotein F0	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Fusion glycoprotein F0	identical protein binding protein binding binding	membrane organization cellular component organization membrane fusion fusion of virus membrane with host plasma membrane viral process cellular process cellular component organization or biogenesis membrane fusion involved in viral entry into host cell virion attachment to host cell biological process involved in interspecies interaction between organisms receptor-mediated virion attachment to host cell adhesion of symbiont to host cell entry receptor-mediated virion attachment to host cell viral life cycle membrane organization cellular component organization membrane fusion fusion of virus membrane with host plasma membrane viral process cellular process cellular component organization or biogenesis membrane fusion involved in viral entry into host cell virion attachment to host cell biological process involved in interspecies interaction between organisms receptor-mediated virion attachment to host cell adhesion of symbiont to host cell entry receptor-mediated virion attachment to host cell viral life cycle adhesion of symbiont to host biological process involved in interaction with host biological process involved in symbiotic interaction symbiont entry into host cell symbiont entry into host positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization regulation of syncytium formation by plasma membrane fusion regulation of developmental process positive regulation of biological process cell-cell fusion modulation by virus of host process modulation by virus of syncytium formation via plasma membrane fusion positive regulation of developmental process symbiont-mediated perturbation of host process anatomical structure development positive regulation of syncytium formation by virus syncytium formation induction by virus of host cell-cell fusion modulation of process of another organism positive regulation of cellular process modulation by virus of host cellular process developmental process regulation of biological process biological regulation positive regulation of syncytium formation by plasma membrane fusion syncytium formation by plasma membrane fusion anatomical structure morphogenesis anatomical structure formation involved in morphogenesis	cell periphery plasma membrane membrane cellular anatomical entity virion component viral membrane viral envelope host cell plasma membrane host cellular component host cell part host cell membrane virion membrane host intracellular part host cell Golgi membrane cell periphery plasma membrane membrane cellular anatomical entity virion component viral membrane viral envelope host cell plasma membrane host cellular component host cell part host cell membrane virion membrane host intracellular part host cell Golgi membrane host cell Golgi apparatus host cell cytoplasm part host cell cytoplasm host cell endomembrane system host intracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR000776	Precursor fusion glycoprotein F0, Paramyxoviridae	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.