6F4Q

Human JMJD5 (Q275C) in complex with Mn(II), NOG and RPS6-A138C (129-144) (complex-2)

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	JmjC_1	e6f4qA1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: JmjC_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.650	Mainly Beta	Sandwich	Jelly Rolls	Cupin	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF13621	Cupin-like domain (Cupin_8)	Cupin-like domain	This cupin like domain shares similarity to the JmjC domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	JmjC domain-containing protein 5	p53 binding protein binding binding oxidoreductase activity peptidyl-arginine 3-dioxygenase activity catalytic activity, acting on a protein oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen catalytic activity 2-oxoglutarate-dependent dioxygenase activity dioxygenase activity histone H3K36 demethylase activity protein demethylase activity histone demethylase activity demethylase activity p53 binding protein binding binding oxidoreductase activity peptidyl-arginine 3-dioxygenase activity catalytic activity, acting on a protein oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen catalytic activity 2-oxoglutarate-dependent dioxygenase activity dioxygenase activity histone H3K36 demethylase activity protein demethylase activity histone demethylase activity demethylase activity histone H3 demethylase activity histone modifying activity peptidase activity hydrolase activity endopeptidase activity chromatin binding methylated histone binding modification-dependent protein binding histone binding methylation-dependent protein binding cation binding ion binding metal ion binding small molecule binding aminopeptidase activity exopeptidase activity	regulation of cellular process cellular biosynthetic process negative regulation of biological process RNA metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of cellular process cellular biosynthetic process negative regulation of biological process RNA metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process negative regulation of metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process fibroblast proliferation cell population proliferation protein destabilization regulation of protein stability regulation of biological quality positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process cellular response to stimulus regulation of signaling response to stimulus signaling regulation of signal transduction signal transduction by p53 class mediator intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus regulation of signal transduction by p53 class mediator regulation of cell communication signal transduction cell cycle G2/M phase transition mitotic cell cycle process G2/M transition of mitotic cell cycle cell cycle phase transition cell cycle mitotic cell cycle cell cycle process mitotic cell cycle phase transition proteolysis protein metabolic process rhythmic process circadian regulation of gene expression circadian rhythm developmental process multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching chordate embryonic development anatomical structure development embryo development in utero embryonic development	intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome cellular anatomical entity non-membrane-bounded organelle cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome cellular anatomical entity non-membrane-bounded organelle cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
B	40S ribosomal protein S6	RNA binding binding organic cyclic compound binding nucleic acid binding structural molecule activity structural constituent of ribosome protein binding kinase binding enzyme binding protein kinase binding	developmental process multicellular organismal process erythrocyte development cellular developmental process homeostatic process hemopoiesis cell development erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation immune system process cell differentiation anatomical structure development myeloid cell development developmental process multicellular organismal process erythrocyte development cellular developmental process homeostatic process hemopoiesis cell development erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation immune system process cell differentiation anatomical structure development myeloid cell development homeostasis of number of cells cellular process myeloid cell homeostasis erythrocyte homeostasis placenta development animal organ development regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death multicellular organism development anatomical structure morphogenesis embryonic morphogenesis embryo development gastrulation sexual reproduction reproductive process multicellular organismal reproductive process oogenesis cellular process involved in reproduction in multicellular organism female gamete generation developmental process involved in reproduction gamete generation germ cell development mammalian oogenesis stage positive regulation of programmed cell death positive regulation of biological process positive regulation of apoptotic process positive regulation of cellular process ribonucleoprotein complex biogenesis cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process rRNA processing gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process cellular component biogenesis RNA biosynthetic process ribosome biogenesis nucleic acid biosynthetic process biosynthetic process metabolic process macromolecule metabolic process cellular component organization or biogenesis RNA processing rRNA metabolic process leukocyte apoptotic process lymphocyte apoptotic process leukocyte homeostasis T cell homeostasis activation-induced cell death of T cells T cell apoptotic process lymphocyte homeostasis cell activation mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation T cell differentiation in thymus T cell activation T cell differentiation leukocyte differentiation cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation translation cytoplasmic translation protein metabolic process mitotic cell cycle process cell cycle phase transition cell cycle G1/S transition of mitotic cell cycle cell cycle G1/S phase transition mitotic cell cycle mitotic cell cycle phase transition cell cycle process ribosomal small subunit biogenesis cellular response to stimulus TOR signaling response to stimulus signaling intracellular signal transduction cell communication signal transduction immune response cell activation involved in immune response leukocyte proliferation immune effector process T cell proliferation involved in immune response T cell activation involved in immune response mononuclear cell proliferation lymphocyte proliferation leukocyte activation involved in immune response lymphocyte activation involved in immune response T cell proliferation chemical homeostasis glucose homeostasis carbohydrate homeostasis	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane cytoplasm cytosol somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection nucleoplasm cytoplasmic ribonucleoprotein granule supramolecular complex ribonucleoprotein granule protein-containing complex small ribosomal subunit ribosomal subunit ribonucleoprotein complex ribosome cytosolic ribosome preribosome small-subunit processome perinuclear region of cytoplasm cell body cytosolic small ribosomal subunit endoplasmic reticulum endomembrane system

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR003347	JmjC domain	Domain
A	IPR041667	Cupin-like domain 8	Domain
B	IPR018282	Small ribosomal subunit protein eS6, conserved site	Conserved Site
B	IPR001377	Small ribosomal subunit protein eS6	Family
B	IPR014401	Small ribosomal subunit protein eS6-like	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q8N371	hepatocellular carcinoma pancreatic ductal adenocarcinoma peripheral arterial disease
B	Pharos: P62753	breast carcinoma breast cancer Disease Progression hepatocellular carcinoma lung cancer gastric cancer hereditary diffuse gastric adenocarcinoma gastric neoplasm pancreatic intraductal papillary-mucinous neoplasm

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.