Annotations: 6G8F

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.58.1370	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
A	2.60.120.650	Mainly Beta	Sandwich	Jelly Rolls	Cupin	CATH (4.3.0)
A	2.10.110.20	Mainly Beta	Ribbon	Cysteine Rich Protein		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF21322	Lysine-specific demethylase 6/UTY, C-terminal helical domain (KDM6_C-hel)	Lysine-specific demethylase 6/UTY, C-terminal helical domain	Histone lysine (K) demethylases (KDMs) catalyse the demethylation of lysine residue from histone tails. This entry incudes KDM6 subfamily that contains a conserved catalytic Jumonji C (JmjC) domain and includes KDM6A (also known as UTX), KDM6B (also ...	Histone lysine (K) demethylases (KDMs) catalyse the demethylation of lysine residue from histone tails. This entry incudes KDM6 subfamily that contains a conserved catalytic Jumonji C (JmjC) domain and includes KDM6A (also known as UTX), KDM6B (also known as JMJD3) and the related histone demethylase UTY [[1-4]. This is the C-terminal helical domain localised adjacent the JmjC domain.	Domain
A	PF02373	JmjC domain, hydroxylase (JmjC)	JmjC domain, hydroxylase	The JmjC domain belongs to the Cupin superfamily [3]. JmjC-domain proteins may be protein hydroxylases that catalyse a novel histone modification [4]. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the ...	The JmjC domain belongs to the Cupin superfamily [3]. JmjC-domain proteins may be protein hydroxylases that catalyse a novel histone modification [4]. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalysing hydroxylation [5].	Domain
A	PF21326	KDM6, GATA-like (KDM6_GATAL)	KDM6, GATA-like	Histone lysine (K) demethylases (KDMs) catalyse the demethylation of lysine residue from histone tails. This entry includes KDM6 subfamily that contains a conserved catalytic Jumonji C (JmjC) domain and includes KDM6A (also known as UTX), KDM6B (also ...	Histone lysine (K) demethylases (KDMs) catalyse the demethylation of lysine residue from histone tails. This entry includes KDM6 subfamily that contains a conserved catalytic Jumonji C (JmjC) domain and includes KDM6A (also known as UTX), KDM6B (also known as JMJD3) and the related histone demethylase UTY (also known as KMD6C) [1,2]. This entry represents the Zn2+-coordinated GATA-like (GATAL) domain [1,2], which seems to be sensitive to redox environment. It is involved in substrate binding [3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Lysine-specific demethylase 6A	DNA binding binding chromatin binding organic cyclic compound binding nucleic acid binding chromatin DNA binding sequence-specific DNA binding double-stranded DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding binding chromatin binding organic cyclic compound binding nucleic acid binding chromatin DNA binding sequence-specific DNA binding double-stranded DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding catalytic activity, acting on a protein protein demethylase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen histone demethylase activity demethylase activity dioxygenase activity oxidoreductase activity histone H3 demethylase activity histone modifying activity histone H3K27me2/H3K27me3 demethylase activity catalytic activity 2-oxoglutarate-dependent dioxygenase activity cation binding ion binding metal ion binding small molecule binding	regulation of biosynthetic process regulation of biological process regulation of cellular process cellular biosynthetic process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process regulation of biosynthetic process regulation of biological process regulation of cellular process cellular biosynthetic process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process cellular component organization chromatin organization chromatin remodeling cellular component organization or biogenesis	membrane-bounded organelle protein-containing complex histone methyltransferase complex intracellular anatomical structure catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex intracellular organelle lumen intracellular organelle nucleoplasm membrane-bounded organelle protein-containing complex histone methyltransferase complex intracellular anatomical structure catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle methyltransferase complex nuclear lumen MLL3/4 complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR048562	Lysine-specific demethylase 6A/B-like, C-terminal helical domain	Domain
A	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
A	IPR003347	JmjC domain	Domain
A	IPR046941	Lysine-specific demethylase 6, GATA-like domain superfamily	Homologous Superfamily
A	IPR048560	Lysine-specific demethylase 6A/B-like, GATA-like	Domain
A	IPR051630	Transcriptional Corepressor and Histone Demethylase	Family
A	IPR019734	Tetratricopeptide repeat	Repeat

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O15550	Kabuki syndrome urinary bladder cancer transitional cell carcinoma esophageal squamous cell carcinoma adenoid cystic carcinoma prostate cancer salivary gland adenoid cystic carcinoma cancer intellectual disability Kabuki syndrome 2 medulloblastoma lung adenocarcinoma Neoplasms ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Kabuki syndrome urinary bladder cancer transitional cell carcinoma esophageal squamous cell carcinoma adenoid cystic carcinoma prostate cancer salivary gland adenoid cystic carcinoma cancer intellectual disability Kabuki syndrome 2 medulloblastoma lung adenocarcinoma Neoplasms ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia bladder benign neoplasm congenital anemia Down syndrome osteogenesis imperfecta pancreatic intraductal papillary-mucinous carcinoma plasma cell myeloma atypical teratoid rhabdoid tumor bladder carcinoma in situ chronic myelomonocytic leukemia urinary bladder carcinoma large cell medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm benign neoplasm psoriasis breast carcinoma tuberculosis colorectal cancer urinary bladder neoplasm glioblastoma Kabuki syndrome 1

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.