Annotations: 6GBS

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	DcpS	e6gbsA1	A: a+b two layers	X: mRNA decapping enzyme DcpS N-terminal domain (From Topology)	H: mRNA decapping enzyme DcpS N-terminal domain (From Topology)	T: mRNA decapping enzyme DcpS N-terminal domain	F: DcpS	ECOD (1.6)
A	DcpS_C	e6gbsA2	A: a+b three layers	X: HIT-like	H: HIT-related (From Topology)	T: HIT-related	F: DcpS_C	ECOD (1.6)
B	DcpS	e6gbsB1	A: a+b two layers	X: mRNA decapping enzyme DcpS N-terminal domain (From Topology)	H: mRNA decapping enzyme DcpS N-terminal domain (From Topology)	T: mRNA decapping enzyme DcpS N-terminal domain	F: DcpS	ECOD (1.6)
B	DcpS_C	e6gbsB2	A: a+b three layers	X: HIT-like	H: HIT-related (From Topology)	T: HIT-related	F: DcpS_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.428.10	Alpha Beta	2-Layer Sandwich	HIT family, subunit A	HIT-like	CATH (utative)
B	3.30.428.10	Alpha Beta	2-Layer Sandwich	HIT family, subunit A	HIT-like	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF11969	Scavenger mRNA decapping enzyme C-term binding (DcpS_C)	Scavenger mRNA decapping enzyme C-term binding	-	Family
A, B	PF05652	Scavenger mRNA decapping enzyme (DcpS) N-terminal (DcpS)	Scavenger mRNA decapping enzyme (DcpS) N-terminal	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Putative mRNA decapping protein	hydrolase activity catalytic activity RNA binding binding organic cyclic compound binding RNA 7-methylguanosine cap binding nucleic acid binding RNA cap binding	regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process post-transcriptional regulation of gene expression regulation of RNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological quality RNA catabolic process mRNA catabolic process regulation of biological process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process post-transcriptional regulation of gene expression regulation of RNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological quality RNA catabolic process mRNA catabolic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process negative regulation of metabolic process positive regulation of mRNA metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process nucleobase-containing compound catabolic process positive regulation of RNA metabolic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process nucleic acid catabolic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process deadenylation-dependent decapping of nuclear-transcribed mRNA regulation of metabolic process RNA decapping nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay catabolic process cellular biosynthetic process positive regulation of biological process RNA metabolic process macromolecule catabolic process mRNA destabilization regulation of mRNA catabolic process negative regulation of cellular process mRNA methylguanosine-cap decapping negative regulation of macromolecule metabolic process regulation of biosynthetic process nuclear-transcribed mRNA catabolic process RNA destabilization biological regulation regulation of macromolecule metabolic process regulation of catabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of catabolic process regulation of mRNA stability negative regulation of biosynthetic process positive regulation of mRNA catabolic process regulation of RNA stability cellular process regulation of mRNA metabolic process	intracellular anatomical structure cytoplasmic ribonucleoprotein granule cellular anatomical entity ribonucleoprotein granule intracellular organelle organelle intracellular non-membrane-bounded organelle cytoplasm supramolecular complex P-body non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036265	HIT-like superfamily	Homologous Superfamily
A, B	IPR011145	Scavenger mRNA decapping enzyme, N-terminal	Homologous Superfamily
A, B	IPR008594	Scavenger mRNA decapping enzyme DcpS/DCS2	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.