6GKD
human NBD1 of CFTR in complex with nanobodies D12 and G3a
External Resource: Annotation
- Domain Annotation: SCOP/SCOPe Classification
- Domain Annotation: SCOP2 Classification
- Domain Annotation: ECOD Classification
- Domain Annotation: CATH
- SAbDab Antibody Annotation
- Protein Family Annotation
- Gene Ontology: Gene Product Annotation
- InterPro: Protein Family Classification
- Pharos: Disease Associations
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2B Superfamily | ABC transporter-like P-loop ATPases | 8056723 | 3002020 | SCOP2B (2022-06-29) |
G [auth I] | SCOP2B Superfamily | ABC transporter-like P-loop ATPases | 8056723 | 3002020 | SCOP2B (2022-06-29) |
J [auth L] | SCOP2B Superfamily | ABC transporter-like P-loop ATPases | 8056723 | 3002020 | SCOP2B (2022-06-29) |
M [auth O] | SCOP2B Superfamily | ABC transporter-like P-loop ATPases | 8056723 | 3002020 | SCOP2B (2022-06-29) |
P [auth R] | SCOP2B Superfamily | ABC transporter-like P-loop ATPases | 8056723 | 3002020 | SCOP2B (2022-06-29) |
D [auth F] | SCOP2B Superfamily | ABC transporter-like P-loop ATPases | 8056723 | 3002020 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | V-set_8 | e6gkdB1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_8 | ECOD (1.6) |
E [auth G] | V-set_8 | e6gkdG1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_8 | ECOD (1.6) |
H [auth J] | V-set_8 | e6gkdJ1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_8 | ECOD (1.6) |
K [auth M] | V-set_8 | e6gkdM1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_8 | ECOD (1.6) |
N [auth P] | V-set_8 | e6gkdP1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_8 | ECOD (1.6) |
Q [auth S] | V-set_8 | e6gkdS1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_8 | ECOD (1.6) |
A | ABC_tran_1 | e6gkdA1 | A: a/b three-layered sandwiches | X: P-loop domains-like | H: P-loop domains-related | T: P-loop containing nucleoside triphosphate hydrolases | F: ABC_tran_1 | ECOD (1.6) |
G [auth I] | ABC_tran_1 | e6gkdI1 | A: a/b three-layered sandwiches | X: P-loop domains-like | H: P-loop domains-related | T: P-loop containing nucleoside triphosphate hydrolases | F: ABC_tran_1 | ECOD (1.6) |
J [auth L] | ABC_tran_1 | e6gkdL1 | A: a/b three-layered sandwiches | X: P-loop domains-like | H: P-loop domains-related | T: P-loop containing nucleoside triphosphate hydrolases | F: ABC_tran_1 | ECOD (1.6) |
M [auth O] | ABC_tran_1 | e6gkdO1 | A: a/b three-layered sandwiches | X: P-loop domains-like | H: P-loop domains-related | T: P-loop containing nucleoside triphosphate hydrolases | F: ABC_tran_1 | ECOD (1.6) |
P [auth R] | ABC_tran_1 | e6gkdR1 | A: a/b three-layered sandwiches | X: P-loop domains-like | H: P-loop domains-related | T: P-loop containing nucleoside triphosphate hydrolases | F: ABC_tran_1 | ECOD (1.6) |
D [auth F] | ABC_tran_1 | e6gkdF1 | A: a/b three-layered sandwiches | X: P-loop domains-like | H: P-loop domains-related | T: P-loop containing nucleoside triphosphate hydrolases | F: ABC_tran_1 | ECOD (1.6) |
C | V-set_8 | e6gkdC1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_8 | ECOD (1.6) |
F [auth H] | V-set_8 | e6gkdH1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_8 | ECOD (1.6) |
I [auth K] | V-set_8 | e6gkdK1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_8 | ECOD (1.6) |
L [auth N] | V-set_8 | e6gkdN1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_8 | ECOD (1.6) |
O [auth Q] | V-set_8 | e6gkdQ1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_8 | ECOD (1.6) |
R [auth T] | V-set_8 | e6gkdT1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_8 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 3.40.50.300 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | P-loop containing nucleotide triphosphate hydrolases | CATH (utative) |
G [auth I] | 3.40.50.300 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | P-loop containing nucleotide triphosphate hydrolases | CATH (utative) |
J [auth L] | 3.40.50.300 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | P-loop containing nucleotide triphosphate hydrolases | CATH (utative) |
M [auth O] | 3.40.50.300 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | P-loop containing nucleotide triphosphate hydrolases | CATH (utative) |
P [auth R] | 3.40.50.300 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | P-loop containing nucleotide triphosphate hydrolases | CATH (utative) |
D [auth F] | 3.40.50.300 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | P-loop containing nucleotide triphosphate hydrolases | CATH (utative) |
SAbDab Antibody Annotation SAbDab Database Homepage
Chain | Chain Class | Chain Subclass | Chain Type | Antigen Name(s) | Provenance Source |
---|---|---|---|---|---|
Heavy Chain | IGHV1 | - | cystic fibrosis transmembrane conductance regulator | SAbDab (2024-11-01) | |
Heavy Chain | IGHV1 | - | cystic fibrosis transmembrane conductance regulator | SAbDab (2024-11-01) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00005 | ABC transporter (ABC_tran) | ABC transporter | ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are comp ... | Domain | |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR047082 | Cystic fibrosis transmembrane conductance regulator, ATP-binding cassette domain 1 | Domain | |
IPR003439 | ABC transporter-like, ATP-binding domain | Domain | |
IPR009147 | Cystic fibrosis transmembrane conductance regulator | Family | |
IPR025837 | CFTR regulator domain | Domain | |
IPR027417 | P-loop containing nucleoside triphosphate hydrolase | Homologous Superfamily | |
IPR003593 | AAA+ ATPase domain | Domain | |
IPR011527 | ABC transporter type 1, transmembrane domain | Domain | |
IPR017871 | ABC transporter-like, conserved site | Conserved Site | |
IPR036640 | ABC transporter type 1, transmembrane domain superfamily | Homologous Superfamily | |
IPR050173 | ATP-binding cassette transporter C-like | Family |