Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad6gkda_ Alpha and beta proteins (a/b) P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases ABC transporter ATPase domain-like Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
D [auth F]d6gkdf_ Alpha and beta proteins (a/b) P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases ABC transporter ATPase domain-like Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
J [auth L]d6gkdl_ Alpha and beta proteins (a/b) P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases ABC transporter ATPase domain-like Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
M [auth O]d6gkdo_ Alpha and beta proteins (a/b) P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases ABC transporter ATPase domain-like Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
P [auth R]d6gkdr_ Alpha and beta proteins (a/b) P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases ABC transporter ATPase domain-like Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
G [auth I]d6gkdi_ Alpha and beta proteins (a/b) P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases ABC transporter ATPase domain-like Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Bd6gkdb1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin automated matches automated matches (Lama glama ) [TaxId: 9844 ], SCOPe (2.08)
Bd6gkdb2 Artifacts Tags Tags Tags N-terminal Tags (Lama glama ) [TaxId: 9844 ], SCOPe (2.08)
E [auth G]d6gkdg1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin automated matches automated matches (Lama glama ) [TaxId: 9844 ], SCOPe (2.08)
E [auth G]d6gkdg2 Artifacts Tags Tags Tags N-terminal Tags (Lama glama ) [TaxId: 9844 ], SCOPe (2.08)
H [auth J]d6gkdj1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin automated matches automated matches (Lama glama ) [TaxId: 9844 ], SCOPe (2.08)
H [auth J]d6gkdj2 Artifacts Tags Tags Tags N-terminal Tags (Lama glama ) [TaxId: 9844 ], SCOPe (2.08)
K [auth M]d6gkdm1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin automated matches automated matches (Lama glama ) [TaxId: 9844 ], SCOPe (2.08)
K [auth M]d6gkdm2 Artifacts Tags Tags Tags N-terminal Tags (Lama glama ) [TaxId: 9844 ], SCOPe (2.08)
N [auth P]d6gkdp1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin automated matches automated matches (Lama glama ) [TaxId: 9844 ], SCOPe (2.08)
N [auth P]d6gkdp2 Artifacts Tags Tags Tags N-terminal Tags (Lama glama ) [TaxId: 9844 ], SCOPe (2.08)
Q [auth S]d6gkds1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin automated matches automated matches (Lama glama ) [TaxId: 9844 ], SCOPe (2.08)
Q [auth S]d6gkds2 Artifacts Tags Tags Tags N-terminal Tags (Lama glama ) [TaxId: 9844 ], SCOPe (2.08)
Cd6gkdc1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin automated matches automated matches (Lama glama ) [TaxId: 9844 ], SCOPe (2.08)
Cd6gkdc2 Artifacts Tags Tags Tags N-terminal Tags (Lama glama ) [TaxId: 9844 ], SCOPe (2.08)
F [auth H]d6gkdh1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin automated matches automated matches (Lama glama ) [TaxId: 9844 ], SCOPe (2.08)
F [auth H]d6gkdh2 Artifacts Tags Tags Tags N-terminal Tags (Lama glama ) [TaxId: 9844 ], SCOPe (2.08)
I [auth K]d6gkdk1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin automated matches automated matches (Lama glama ) [TaxId: 9844 ], SCOPe (2.08)
I [auth K]d6gkdk2 Artifacts Tags Tags Tags N-terminal Tags (Lama glama ) [TaxId: 9844 ], SCOPe (2.08)
L [auth N]d6gkdn1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin automated matches automated matches (Lama glama ) [TaxId: 9844 ], SCOPe (2.08)
L [auth N]d6gkdn2 Artifacts Tags Tags Tags N-terminal Tags (Lama glama ) [TaxId: 9844 ], SCOPe (2.08)
O [auth Q]d6gkdq1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin automated matches automated matches (Lama glama ) [TaxId: 9844 ], SCOPe (2.08)
O [auth Q]d6gkdq2 Artifacts Tags Tags Tags N-terminal Tags (Lama glama ) [TaxId: 9844 ], SCOPe (2.08)
R [auth T]d6gkdt1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin automated matches automated matches (Lama glama ) [TaxId: 9844 ], SCOPe (2.08)
R [auth T]d6gkdt2 Artifacts Tags Tags Tags N-terminal Tags (Lama glama ) [TaxId: 9844 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyABC transporter-like P-loop ATPases 8056723 3002020 SCOP2B (2022-06-29)
D [auth F]SCOP2B SuperfamilyABC transporter-like P-loop ATPases 8056723 3002020 SCOP2B (2022-06-29)
J [auth L]SCOP2B SuperfamilyABC transporter-like P-loop ATPases 8056723 3002020 SCOP2B (2022-06-29)
M [auth O]SCOP2B SuperfamilyABC transporter-like P-loop ATPases 8056723 3002020 SCOP2B (2022-06-29)
P [auth R]SCOP2B SuperfamilyABC transporter-like P-loop ATPases 8056723 3002020 SCOP2B (2022-06-29)
G [auth I]SCOP2B SuperfamilyABC transporter-like P-loop ATPases 8056723 3002020 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AABC_tran_1e6gkdA1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: ABC_tran_1ECOD (1.6)
D [auth F]ABC_tran_1e6gkdF1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: ABC_tran_1ECOD (1.6)
J [auth L]ABC_tran_1e6gkdL1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: ABC_tran_1ECOD (1.6)
M [auth O]ABC_tran_1e6gkdO1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: ABC_tran_1ECOD (1.6)
P [auth R]ABC_tran_1e6gkdR1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: ABC_tran_1ECOD (1.6)
G [auth I]ABC_tran_1e6gkdI1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: ABC_tran_1ECOD (1.6)
BV-set_8e6gkdB1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
E [auth G]V-set_8e6gkdG1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
H [auth J]V-set_8e6gkdJ1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
K [auth M]V-set_8e6gkdM1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
N [auth P]V-set_8e6gkdP1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
Q [auth S]V-set_8e6gkdS1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
CV-set_8e6gkdC1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
F [auth H]V-set_8e6gkdH1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
I [auth K]V-set_8e6gkdK1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
L [auth N]V-set_8e6gkdN1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
O [auth Q]V-set_8e6gkdQ1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
R [auth T]V-set_8e6gkdT1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

SAbDab Antibody Annotation SAbDab Database Homepage

ChainChain ClassChain SubclassChain TypeAntigen Name(s) Provenance Source
Heavy ChainIGHV1 -cystic fibrosis transmembrane conductance regulatorSAbDab (2024-11-15)
Heavy ChainIGHV1 -cystic fibrosis transmembrane conductance regulatorSAbDab (2024-11-15)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00005ABC transporter (ABC_tran)ABC transporterABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are comp ...ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain Pfam:PF00664. These four domains may belong to a single polypeptide as in Swiss:P13569, or belong in different polypeptide chains.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Cystic fibrosis transmembrane conductance regulator
Nanobody D12---
Nanobody G3a---

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR047082Cystic fibrosis transmembrane conductance regulator, ATP-binding cassette domain 1Domain
IPR003439ABC transporter-like, ATP-binding domainDomain
IPR009147Cystic fibrosis transmembrane conductance regulatorFamily
IPR025837CFTR regulator domainDomain
IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily
IPR003593AAA+ ATPase domainDomain
IPR011527ABC transporter type 1, transmembrane domainDomain
IPR017871ABC transporter-like, conserved siteConserved Site
IPR036640ABC transporter type 1, transmembrane domain superfamilyHomologous Superfamily
IPR050173ATP-binding cassette transporter C-likeFamily

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
PharosP13569