6GU7

CDK1/Cks2 in complex with AZD5438

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6gu7a_	Alpha and beta proteins (a+b)	Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	Protein kinases, catalytic subunit	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d6gu7e_	Alpha and beta proteins (a+b)	Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	Protein kinases, catalytic subunit	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d6gu7c_	Alpha and beta proteins (a+b)	Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	Protein kinases, catalytic subunit	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G	d6gu7g_	Alpha and beta proteins (a+b)	Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	Protein kinases, catalytic subunit	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d6gu7d_	Alpha and beta proteins (a+b)	Cell cycle regulatory proteins	Cell cycle regulatory proteins	Cell cycle regulatory proteins	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d6gu7f_	Alpha and beta proteins (a+b)	Cell cycle regulatory proteins	Cell cycle regulatory proteins	Cell cycle regulatory proteins	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H	d6gu7h_	Alpha and beta proteins (a+b)	Cell cycle regulatory proteins	Cell cycle regulatory proteins	Cell cycle regulatory proteins	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d6gu7b_	Alpha and beta proteins (a+b)	Cell cycle regulatory proteins	Cell cycle regulatory proteins	Cell cycle regulatory proteins	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Protein kinase-like (PK-like)	8062438	3000066	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Protein kinase-like (PK-like)	8062438	3000066	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Protein kinase-like (PK-like)	8062438	3000066	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Protein kinase-like (PK-like)	8062438	3000066	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Cell cycle regulatory proteins	8098018	3000311	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Cell cycle regulatory proteins	8098018	3000311	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Cell cycle regulatory proteins	8098018	3000311	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Cell cycle regulatory proteins	8098018	3000311	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Pkinase_Tyr	e6gu7A1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
E	Pkinase_Tyr	e6gu7E1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
C	Pkinase_Tyr	e6gu7C1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
G	Pkinase_Tyr	e6gu7G1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
D	CKS	e6gu7D1	A: a+b complex topology	X: Cell cycle regulatory proteins (From Topology)	H: Cell cycle regulatory proteins (From Topology)	T: Cell cycle regulatory proteins	F: CKS	ECOD (1.6)
F	CKS	e6gu7F1	A: a+b complex topology	X: Cell cycle regulatory proteins (From Topology)	H: Cell cycle regulatory proteins (From Topology)	T: Cell cycle regulatory proteins	F: CKS	ECOD (1.6)
H	CKS	e6gu7H1	A: a+b complex topology	X: Cell cycle regulatory proteins (From Topology)	H: Cell cycle regulatory proteins (From Topology)	T: Cell cycle regulatory proteins	F: CKS	ECOD (1.6)
B	CKS	e6gu7B1	A: a+b complex topology	X: Cell cycle regulatory proteins (From Topology)	H: Cell cycle regulatory proteins (From Topology)	T: Cell cycle regulatory proteins	F: CKS	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
A	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
E	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
E	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
C	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
C	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
G	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
G	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
D	3.30.170.10	Alpha Beta	2-Layer Sandwich	Cyclin-Dependent Kinase Subunit Type 2	Cyclin-dependent kinase, regulatory subunit	CATH (4.3.0)
F	3.30.170.10	Alpha Beta	2-Layer Sandwich	Cyclin-Dependent Kinase Subunit Type 2	Cyclin-dependent kinase, regulatory subunit	CATH (4.3.0)
H	3.30.170.10	Alpha Beta	2-Layer Sandwich	Cyclin-Dependent Kinase Subunit Type 2	Cyclin-dependent kinase, regulatory subunit	CATH (4.3.0)
B	3.30.170.10	Alpha Beta	2-Layer Sandwich	Cyclin-Dependent Kinase Subunit Type 2	Cyclin-dependent kinase, regulatory subunit	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E, G	PF00069	Protein kinase domain (Pkinase)	Protein kinase domain	-	Domain
B, D, F, H	PF01111	Cyclin-dependent kinase regulatory subunit (CKS)	Cyclin-dependent kinase regulatory subunit	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E, G	Cyclin-dependent kinase 1	kinase activity transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding kinase activity transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity catalytic activity, acting on a protein protein kinase activity cyclin-dependent protein kinase activity phosphotransferase activity, alcohol group as acceptor RNA polymerase II CTD heptapeptide repeat modifying activity RNA polymerase II CTD heptapeptide repeat kinase activity histone modifying activity histone kinase activity protein binding virus receptor activity exogenous protein binding chromatin binding Hsp70 protein binding protein-folding chaperone binding heat shock protein binding cyclin binding protein serine kinase activity	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process response to chemical response to xenobiotic stimulus response to wounding response to axon injury cell division regulation of cellular process cellular biosynthetic process positive regulation of biological process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process response to chemical response to xenobiotic stimulus response to wounding response to axon injury cell division regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process multicellular organismal process regulation of growth positive regulation of cell population proliferation regulation of cardiac muscle tissue growth regulation of developmental process developmental growth cardiac muscle cell proliferation organ growth striated muscle tissue development positive regulation of developmental process multicellular organism development positive regulation of cardiac muscle cell proliferation regulation of organ growth regulation of heart growth regulation of cardiac muscle cell proliferation anatomical structure development muscle cell proliferation regulation of multicellular organismal process cardiac muscle tissue growth muscle tissue development positive regulation of developmental growth system development striated muscle cell proliferation positive regulation of heart growth developmental process heart development heart growth regulation of multicellular organismal development cell population proliferation regulation of developmental growth cardiac muscle tissue development positive regulation of organ growth animal organ development growth tissue development circulatory system development positive regulation of growth regulation of cell population proliferation positive regulation of cardiac muscle tissue growth positive regulation of multicellular organismal process cellular component organization organelle organization chromosome condensation chromosome organization cellular component organization or biogenesis apoptotic process cell death programmed cell death membrane organization cellular component disassembly nuclear membrane disassembly mitotic cell cycle membrane disassembly nuclear membrane organization mitotic nuclear membrane disassembly nucleus organization mitotic cell cycle process nuclear envelope organization cell cycle endomembrane system organization cell cycle process positive regulation of nucleobase-containing compound metabolic process positive regulation of DNA replication primary metabolic process DNA metabolic process nucleic acid metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process DNA replication positive regulation of DNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of DNA metabolic process regulation of DNA replication establishment of organelle localization regulation of localization regulation of chromosome segregation cellular localization regulation of cellular component organization mitotic metaphase chromosome alignment metaphase chromosome alignment localization regulation of attachment of mitotic spindle microtubules to kinetochore chromosome localization organelle localization establishment of localization in cell mitotic sister chromatid segregation regulation of attachment of spindle microtubules to kinetochore regulation of cell cycle chromosome segregation mitotic nuclear division attachment of spindle microtubules to kinetochore regulation of cell cycle process organelle fission attachment of mitotic spindle microtubules to kinetochore sister chromatid segregation regulation of chromosome organization establishment of localization regulation of organelle organization regulation of mitotic sister chromatid segregation nuclear division regulation of sister chromatid segregation nuclear chromosome segregation regulation of metaphase plate congression establishment of chromosome localization epithelium development cellular developmental process cell differentiation epithelial cell differentiation aerobic respiration cellular respiration oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain regulation of generation of precursor metabolites and energy respiratory electron transport chain regulation of mitochondrial ATP synthesis coupled electron transport positive regulation of mitochondrial ATP synthesis coupled electron transport generation of precursor metabolites and energy mitochondrial ATP synthesis coupled electron transport protein phosphorylation phosphorylation macromolecule modification peptidyl-amino acid modification phosphate-containing compound metabolic process peptidyl-threonine modification protein metabolic process protein modification process phosphorus metabolic process peptidyl-threonine phosphorylation response to toxic substance cell migration cell motility protein localization establishment of protein localization nitrogen compound transport regulation of protein localization nucleocytoplasmic transport transport positive regulation of nucleocytoplasmic transport nuclear transport positive regulation of establishment of protein localization regulation of protein localization to nucleus positive regulation of protein transport import into nucleus regulation of protein import into nucleus cellular macromolecule localization protein import into nucleus positive regulation of intracellular transport regulation of intracellular transport regulation of transport positive regulation of protein localization to nucleus regulation of establishment of protein localization positive regulation of protein import into nucleus intracellular transport regulation of nucleocytoplasmic transport protein localization to nucleus regulation of protein transport positive regulation of transport establishment of protein localization to organelle regulation of cellular localization protein transport macromolecule localization protein localization to organelle positive regulation of protein localization regulation of intracellular protein transport positive regulation of intracellular protein transport intracellular protein transport regulation of glial cell differentiation peripheral nervous system development regulation of cell differentiation nervous system development regulation of Schwann cell differentiation neurogenesis gliogenesis glial cell differentiation Schwann cell differentiation fibroblast proliferation DNA repair cell cycle phase transition G1/S transition of mitotic cell cycle cell cycle G1/S phase transition mitotic cell cycle phase transition positive regulation of organelle organization positive regulation of cellular component organization positive regulation of cell cycle process positive regulation of chromosome segregation positive regulation of mitotic sister chromatid segregation positive regulation of cell cycle positive regulation of chromosome organization peptidyl-serine modification peptidyl-serine phosphorylation protein deubiquitination protein modification by small protein removal post-translational protein modification protein modification by small protein conjugation or removal sexual reproduction reproductive process fertilization pronuclear fusion organelle fusion karyogamy single fertilization cell cycle G2/M phase transition G2/M transition of mitotic cell cycle cellular response to chemical stimulus cellular response to organic cyclic compound response to organic cyclic compound cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly response to copper ion response to metal ion Golgi inheritance organelle inheritance Golgi disassembly organelle disassembly Golgi organization protein localization to chromosome, centromeric region protein localization to kinetochore protein localization to chromosome protein localization to condensed chromosome rhythmic process circadian rhythm regulation of circadian rhythm negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death negative regulation of apoptotic process negative regulation of cellular process signaling intracellular signal transduction cell communication intracellular signaling cassette MAPK cascade ERK1 and ERK2 cascade signal transduction response to activity response to alcohol response to oxygen-containing compound response to ethanol cellular response to oxidative stress cellular response to chemical stress cellular response to oxygen-containing compound cellular response to hydrogen peroxide response to reactive oxygen species response to hydrogen peroxide response to oxidative stress cellular response to reactive oxygen species ventricular cardiac muscle cell differentiation cardiac muscle cell development cell development muscle cell differentiation muscle structure development striated muscle cell development muscle cell development cardiac cell development cardiac muscle cell differentiation ventricular cardiac muscle cell development cardiocyte differentiation striated muscle cell differentiation regulation of cell cycle phase transition DNA damage checkpoint signaling mitotic G2 DNA damage checkpoint signaling negative regulation of cell cycle negative regulation of mitotic cell cycle mitotic G2/M transition checkpoint regulation of mitotic cell cycle mitotic DNA integrity checkpoint signaling mitotic DNA damage checkpoint signaling negative regulation of cell cycle phase transition negative regulation of mitotic cell cycle phase transition regulation of G2/M transition of mitotic cell cycle DNA integrity checkpoint signaling regulation of cell cycle G2/M phase transition negative regulation of cell cycle process cell cycle checkpoint signaling regulation of mitotic cell cycle phase transition mitotic cell cycle checkpoint signaling negative regulation of cell cycle G2/M phase transition signal transduction in response to DNA damage negative regulation of G2/M transition of mitotic cell cycle microtubule organizing center organization microtubule cytoskeleton organization centrosome cycle microtubule-based process cytoskeleton organization regulation of embryonic development embryo development animal organ regeneration regeneration negative regulation of cellular metabolic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process response to cadmium ion microtubule cytoskeleton organization involved in mitosis positive regulation of mitotic cell cycle phase transition positive regulation of mitotic cell cycle positive regulation of G2/M transition of mitotic cell cycle positive regulation of cell cycle G2/M phase transition positive regulation of cell cycle phase transition response to amine response to nitrogen compound	protein kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex serine/threonine protein kinase complex cyclin-dependent protein kinase holoenzyme complex transferase complex membrane cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region protein kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex serine/threonine protein kinase complex cyclin-dependent protein kinase holoenzyme complex transferase complex membrane cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol cyclin A1-CDK1 complex cyclin B1-CDK1 complex intracellular organelle intracellular non-membrane-bounded organelle chromosome chromosome, telomeric region chromosomal region non-membrane-bounded organelle mitochondrion intracellular membrane-bounded organelle midbody centrosome microtubule organizing center cytoskeleton microtubule cytoskeleton mitotic spindle spindle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen organelle subcompartment endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum membrane cyclin A2-CDK1 complex polymeric cytoskeletal fiber spindle microtubule supramolecular fiber microtubule supramolecular polymer supramolecular complex mitochondrial matrix
B, D, F, H	Cyclin-dependent kinases regulatory subunit 2	kinase activity transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups protein binding binding histone binding ubiquitin binding ubiquitin-like protein binding kinase binding enzyme binding protein kinase binding cyclin-dependent protein serine/threonine kinase activator activity enzyme regulator activity kinase activity transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups protein binding binding histone binding ubiquitin binding ubiquitin-like protein binding kinase binding enzyme binding protein kinase binding cyclin-dependent protein serine/threonine kinase activator activity enzyme regulator activity protein serine/threonine kinase activator activity molecular function activator activity protein kinase regulator activity kinase activator activity enzyme activator activity cyclin-dependent protein serine/threonine kinase regulator activity molecular function regulator activity protein kinase activator activity kinase regulator activity	regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation cellular process cell cycle regulation of cell cycle mitotic cell cycle cell division	protein kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex serine/threonine protein kinase complex cyclin-dependent protein kinase holoenzyme complex transferase complex cullin-RING ubiquitin ligase complex ubiquitin ligase complex SCF ubiquitin ligase complex intracellular protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E, G	IPR000719	Protein kinase domain	Domain
A, C, E, G	IPR050108	Cyclin-dependent kinase	Family
A, C, E, G	IPR017441	Protein kinase, ATP binding site	Binding Site
A, C, E, G	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, C, E, G	IPR008271	Serine/threonine-protein kinase, active site	Active Site
B, D, F, H	IPR000789	Cyclin-dependent kinase, regulatory subunit	Family
B, D, F, H	IPR036858	Cyclin-dependent kinase, regulatory subunit superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C, E, G	Pharos: P06493	diffuse large B-cell lymphoma Liver Cirrhosis, Experimental lung adenocarcinoma malignant colon neoplasm malignant mesothelioma nasopharyngeal carcinoma adrenal cortex carcinoma ovarian cancer pilocytic astrocytoma atypical teratoid rhabdoid tumor Sjogren syndrome breast disease esophageal adenocarcinoma IgA glomerulonephritis large cell medulloblastoma diffuse large B-cell lymphoma Liver Cirrhosis, Experimental lung adenocarcinoma malignant colon neoplasm malignant mesothelioma nasopharyngeal carcinoma adrenal cortex carcinoma ovarian cancer pilocytic astrocytoma atypical teratoid rhabdoid tumor Sjogren syndrome breast disease esophageal adenocarcinoma IgA glomerulonephritis large cell medulloblastoma lung cancer malignant ependymoma malignant pancreatic neoplasm non-small cell lung carcinoma astrocytic tumor pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor breast cancer tuberculosis cancer ductal breast carcinoma in situ glioblastoma interstitial cystitis lymphoplasmacytic lymphoma malignant glioma medulloblastoma oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm atopic eczema psoriasis breast carcinoma ulcerative colitis endometriosis hepatocellular carcinoma invasive ductal breast carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.