6HH5

ADP-ribosylserine hydrolase ARH3 of Latimeria chalumnae in complex with ADP-HPM

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ADP_ribosyl_GH	e6hh5A1	A: alpha bundles	X: ADP-ribosylglycohydrolase (From Topology)	H: ADP-ribosylglycohydrolase (From Topology)	T: ADP-ribosylglycohydrolase	F: ADP_ribosyl_GH	ECOD (1.6)
B	ADP_ribosyl_GH	e6hh5B1	A: alpha bundles	X: ADP-ribosylglycohydrolase (From Topology)	H: ADP-ribosylglycohydrolase (From Topology)	T: ADP-ribosylglycohydrolase	F: ADP_ribosyl_GH	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.4080.10	Mainly Alpha	Orthogonal Bundle	ADP-ribosylglycohydrolase fold	ADP-ribosylation/Crystallin J1	CATH (4.3.0)
B	1.10.4080.10	Mainly Alpha	Orthogonal Bundle	ADP-ribosylglycohydrolase fold	ADP-ribosylation/Crystallin J1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF03747	ADP-ribosylglycohydrolase (ADP_ribosyl_GH)	ADP-ribosylglycohydrolase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	ADP-ribosylhydrolase like 2	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding hydrolase activity, acting on glycosyl bonds hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity poly(ADP-ribose) glycohydrolase activity catalytic activity	regulation of biological process regulation of cellular process necroptotic process negative regulation of programmed cell death negative regulation of necroptotic process biological regulation negative regulation of biological process programmed necrotic cell death regulation of programmed cell death cell death regulation of necroptotic process negative regulation of programmed necrotic cell death negative regulation of cellular process cellular process regulation of biological process regulation of cellular process necroptotic process negative regulation of programmed cell death negative regulation of necroptotic process biological regulation negative regulation of biological process programmed necrotic cell death regulation of programmed cell death cell death regulation of necroptotic process negative regulation of programmed necrotic cell death negative regulation of cellular process cellular process regulation of programmed necrotic cell death programmed cell death cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process cellular response to stress DNA damage response response to stress metabolic process macromolecule metabolic process DNA repair protein de-ADP-ribosylation macromolecule modification protein metabolic process protein modification process peptidyl-serine ADP-deribosylation	intracellular organelle cellular anatomical structure intracellular anatomical structure organelle membraneless organelle intracellular membraneless organelle chromosome membrane-bounded organelle mitochondrion membrane-enclosed lumen intracellular membrane-bounded organelle mitochondrial matrix intracellular organelle lumen organelle lumen intracellular organelle cellular anatomical structure intracellular anatomical structure organelle membraneless organelle intracellular membraneless organelle chromosome membrane-bounded organelle mitochondrion membrane-enclosed lumen intracellular membrane-bounded organelle mitochondrial matrix intracellular organelle lumen organelle lumen cytoplasm nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR050792	ADP-ribosylglycohydrolase	Family
A, B	IPR036705	ADP-ribosylation/Crystallin J1 superfamily	Homologous Superfamily
A, B	IPR005502	ADP-ribosylation/Crystallin J1	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.