6HXI
Structure of ATP citrate lyase from Methanothrix soehngenii in complex with citrate and coenzyme A
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | ATP-grasp_2 | e6hxiA2 | A: a+b complex topology | X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology) | H: Protein kinase/SAICAR synthase/ATP-grasp | T: ATP-grasp | F: ATP-grasp_2 | ECOD (1.6) |
A | Citrate_bind | e6hxiA1 | A: a/b three-layered sandwiches | X: Flavodoxin-like | H: Succinyl-CoA synthetase domains (From Topology) | T: Succinyl-CoA synthetase domains | F: Citrate_bind | ECOD (1.6) |
C | ATP-grasp_2 | e6hxiC1 | A: a+b complex topology | X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology) | H: Protein kinase/SAICAR synthase/ATP-grasp | T: ATP-grasp | F: ATP-grasp_2 | ECOD (1.6) |
C | Citrate_bind | e6hxiC2 | A: a/b three-layered sandwiches | X: Flavodoxin-like | H: Succinyl-CoA synthetase domains (From Topology) | T: Succinyl-CoA synthetase domains | F: Citrate_bind | ECOD (1.6) |
B | Citrate_synt | e6hxiB3 | A: alpha complex topology | X: Citrate synthase-like | H: Citrate synthase (From Topology) | T: Citrate synthase | F: Citrate_synt | ECOD (1.6) |
B | CoA_binding | e6hxiB1 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: NAD(P)-binding Rossmann-fold domains | F: CoA_binding | ECOD (1.6) |
B | Succ_CoA_lig | e6hxiB2 | A: a/b three-layered sandwiches | X: Flavodoxin-like | H: Succinyl-CoA synthetase domains (From Topology) | T: Succinyl-CoA synthetase domains | F: Succ_CoA_lig | ECOD (1.6) |
D | Citrate_synt | e6hxiD1 | A: alpha complex topology | X: Citrate synthase-like | H: Citrate synthase (From Topology) | T: Citrate synthase | F: Citrate_synt | ECOD (1.6) |
D | CoA_binding | e6hxiD3 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: NAD(P)-binding Rossmann-fold domains | F: CoA_binding | ECOD (1.6) |
D | Succ_CoA_lig | e6hxiD2 | A: a/b three-layered sandwiches | X: Flavodoxin-like | H: Succinyl-CoA synthetase domains (From Topology) | T: Succinyl-CoA synthetase domains | F: Succ_CoA_lig | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 3.30.470.110 | Alpha Beta | 2-Layer Sandwich | D-amino Acid Aminotransferase | Chain A, domain 1 | CATH (utative) |
A | 3.40.50.261 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | Succinyl-CoA synthetase domains | CATH (utative) |
C | 3.30.1490.20 | Alpha Beta | 2-Layer Sandwich | Dna Ligase | domain 1 | CATH (utative) |
C | 3.40.50.261 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | Succinyl-CoA synthetase domains | CATH (utative) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF08442 | ATP-grasp domain (ATP-grasp_2) | ATP-grasp domain | - | Domain | |
PF16114 | ATP citrate lyase citrate-binding (Citrate_bind) | ATP citrate lyase citrate-binding | This is the citrate-binding domain of ATP citrate lyase. This domain has a Rossmann fold [1]. | Domain | |
PF00549 | CoA-ligase (Ligase_CoA) | CoA-ligase | This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, malate CoA ligase and ATP-citrate lyase. Some members of the family utilise ATP others use GTP. | Domain | |
PF00285 | Citrate synthase, C-terminal domain (Citrate_synt) | Citrate synthase, C-terminal domain | This is the long, C-terminal part of the enzyme. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR032263 | ATP-citrate synthase, citrate-binding domain | Domain | |
IPR016102 | Succinyl-CoA synthetase-like | Homologous Superfamily | |
IPR013650 | ATP-grasp fold, succinyl-CoA synthetase-type | Domain | |
IPR002020 | Citrate synthase | Family | |
IPR016102 | Succinyl-CoA synthetase-like | Homologous Superfamily | |
IPR016143 | Citrate synthase-like, small alpha subdomain | Homologous Superfamily | |
IPR036291 | NAD(P)-binding domain superfamily | Homologous Superfamily | |
IPR036969 | Citrate synthase superfamily | Homologous Superfamily | |
IPR005811 | ATP-citrate synthase/succinyl-CoA ligase, C-terminal domain | Domain | |
IPR002020 | Citrate synthase | Family | |
IPR016142 | Citrate synthase-like, large alpha subdomain | Homologous Superfamily |