6II2

Crystal structure of alpha-beta hydrolase (ABH) and Makes Caterpillars Floppy (MCF)-Like effectors of Vibrio vulnificus MO6-24/O

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	DUF3242	e6ii2A2	A: alpha complex topology	X: uncharacterized domain of PaTox (From Topology)	H: uncharacterized domain of PaTox (From Topology)	T: uncharacterized domain of PaTox	F: DUF3242	ECOD (1.6)
A	UNK_F_TYPE	e6ii2A3	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: UNK_F_TYPE	ECOD (1.6)
A	Hydrolase_4	e6ii2A1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4	ECOD (1.6)
C	DUF3242	e6ii2C3	A: alpha complex topology	X: uncharacterized domain of PaTox (From Topology)	H: uncharacterized domain of PaTox (From Topology)	T: uncharacterized domain of PaTox	F: DUF3242	ECOD (1.6)
C	UNK_F_TYPE	e6ii2C2	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: UNK_F_TYPE	ECOD (1.6)
C	Hydrolase_4	e6ii2C1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4	ECOD (1.6)
B	DUF3242	e6ii2B3	A: alpha complex topology	X: uncharacterized domain of PaTox (From Topology)	H: uncharacterized domain of PaTox (From Topology)	T: uncharacterized domain of PaTox	F: DUF3242	ECOD (1.6)
B	UNK_F_TYPE	e6ii2B2	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: UNK_F_TYPE	ECOD (1.6)
B	Hydrolase_4	e6ii2B1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4	ECOD (1.6)
D	DUF3242	e6ii2D3	A: alpha complex topology	X: uncharacterized domain of PaTox (From Topology)	H: uncharacterized domain of PaTox (From Topology)	T: uncharacterized domain of PaTox	F: DUF3242	ECOD (1.6)
D	UNK_F_TYPE	e6ii2D2	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: UNK_F_TYPE	ECOD (1.6)
D	Hydrolase_4	e6ii2D1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF03543	Yersinia/Haemophilus virulence surface antigen (Peptidase_C58)	Yersinia/Haemophilus virulence surface antigen	-	Family
A, B, C, D	PF00561	alpha/beta hydrolase fold (Abhydrolase_1)	alpha/beta hydrolase fold	This catalytic domain is found in a very wide range of enzymes.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Putative RTX-toxin	binding lipid binding toxin activity cysteine-type peptidase activity peptidase activity catalytic activity, acting on a protein cysteine-type endopeptidase activity hydrolase activity catalytic activity endopeptidase activity cation binding ion binding metal ion binding small molecule binding binding lipid binding toxin activity cysteine-type peptidase activity peptidase activity catalytic activity, acting on a protein cysteine-type endopeptidase activity hydrolase activity catalytic activity endopeptidase activity cation binding ion binding metal ion binding small molecule binding transferase activity	proteolysis metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process	cellular anatomical structure membrane extracellular region host cell plasma membrane host cellular component host cell part host cell membrane host intracellular part host cell cytoplasm host intracellular region host cell cytosol host cell cytoplasm part

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR000073	Alpha/beta hydrolase fold-1	Domain
A, B, C, D	IPR038383	CGT/MARTX, cysteine protease (CPD) domain superfamily	Homologous Superfamily
A, B, C, D	IPR006473	Peptidase C58, YopT-type domain	Domain
A, B, C, D	IPR029058	Alpha/Beta hydrolase fold	Homologous Superfamily
A, B, C, D	IPR020974	CGT/MARTX, cysteine protease (CPD) domain	Domain
A, B, C, D	IPR049824	RtxA toxin-like, peptidase C80 cysteine binding domain	Domain
A, B, C, D	IPR020972	Dermonecrotic/RTX toxin, membrane localization domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.