Annotations: 6J74

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Terpenoid cyclases/Protein prenyltransferases	8094327	3001024	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PPTA	e6j74A1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PPTA	ECOD (1.6)
B	SQHop_cyclase_C	e6j74B1	A: alpha superhelices	X: Repetitive alpha hairpins	H: alpha/alpha toroid (From Topology)	T: alpha/alpha toroid	F: SQHop_cyclase_C	ECOD (1.6)
C	Longin,Synaptobrevin	e6j74C1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: Longin,Synaptobrevin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.50.10.20	Mainly Alpha	Alpha/alpha barrel	Glycosyltransferase		CATH (utative)
C	3.30.450.50	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	Longin domain	CATH (utative)
C	1.20.5.110	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01239	Protein prenyltransferase alpha subunit repeat (PPTA)	Protein prenyltransferase alpha subunit repeat	-	Repeat
B	PF00432	Prenyltransferase and squalene oxidase repeat (Prenyltrans)	Prenyltransferase and squalene oxidase repeat	-	Repeat
C	PF00957	Synaptobrevin (Synaptobrevin)	Synaptobrevin	-	Family
C	PF13774	Regulated-SNARE-like domain (Longin)	Regulated-SNARE-like domain	Longin is one of the approximately 26 components required for transporting proteins from the ER to the plasma membrane, via the Golgi apparatus. It is necessary for the steps of the transfer from the ER to the Golgi complex [1]. Longins are the only ...	Longin is one of the approximately 26 components required for transporting proteins from the ER to the plasma membrane, via the Golgi apparatus. It is necessary for the steps of the transfer from the ER to the Golgi complex [1]. Longins are the only R-SNAREs that are common to all eukaryotes, and they are characterised by a conserved N-terminal domain with a profilin-like fold called a longin domain [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Protein prenyltransferase alpha subunit repeat-containing protein 1	catalytic activity, acting on a protein protein prenyltransferase activity prenyltransferase activity transferase activity catalytic activity transferase activity, transferring alkyl or aryl (other than methyl) groups	-	intracellular anatomical structure cytoplasm cellular anatomical entity
B	Geranylgeranyl transferase type-2 subunit beta	small GTPase binding protein binding binding enzyme binding GTPase binding catalytic activity, acting on a protein protein geranylgeranyltransferase activity protein prenyltransferase activity Rab geranylgeranyltransferase activity prenyltransferase activity transferase activity catalytic activity transferase activity, transferring alkyl or aryl (other than methyl) groups cation binding small GTPase binding protein binding binding enzyme binding GTPase binding catalytic activity, acting on a protein protein geranylgeranyltransferase activity protein prenyltransferase activity Rab geranylgeranyltransferase activity prenyltransferase activity transferase activity catalytic activity transferase activity, transferring alkyl or aryl (other than methyl) groups cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	macromolecule modification metabolic process primary metabolic process protein metabolic process macromolecule metabolic process protein modification process multicellular organismal process sensory perception of light stimulus system process sensory perception nervous system process visual perception cellular metabolic process protein geranylgeranylation macromolecule modification metabolic process primary metabolic process protein metabolic process macromolecule metabolic process protein modification process multicellular organismal process sensory perception of light stimulus system process sensory perception nervous system process visual perception cellular metabolic process protein geranylgeranylation protein prenylation cellular process prenylation	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane protein-containing complex catalytic complex polyprenyl diphosphate synthase complex Rab-protein geranylgeranyltransferase complex transferase complex
C	Synaptobrevin homolog YKT6	SNAP receptor activity protein-macromolecule adaptor activity molecular adaptor activity cell adhesion molecule binding cadherin binding protein binding binding protein-cysteine S-acyltransferase activity catalytic activity, acting on a protein acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity protein-cysteine S-palmitoyltransferase activity S-acyltransferase activity SNAP receptor activity protein-macromolecule adaptor activity molecular adaptor activity cell adhesion molecule binding cadherin binding protein binding binding protein-cysteine S-acyltransferase activity catalytic activity, acting on a protein acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity protein-cysteine S-palmitoyltransferase activity S-acyltransferase activity catalytic activity palmitoyltransferase activity	protein localization establishment of protein localization cellular localization nitrogen compound transport transport establishment of localization localization protein transport cellular macromolecule localization macromolecule localization cellular process secretion export from cell membrane docking protein localization establishment of protein localization cellular localization nitrogen compound transport transport establishment of localization localization protein transport cellular macromolecule localization macromolecule localization cellular process secretion export from cell membrane docking vesicle-mediated transport organelle localization by membrane tethering secretion by cell exocytosis organelle localization vesicle docking exocytic process vesicle docking involved in exocytosis establishment of localization in cell intracellular transport endoplasmic reticulum to Golgi vesicle-mediated transport Golgi vesicle transport endosomal transport cytosolic transport retrograde transport, endosome to Golgi vesicle localization establishment of organelle localization establishment of vesicle localization vesicle targeting	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle cytosol SNARE complex protein-containing complex membrane membrane protein complex cell periphery membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle cytosol SNARE complex protein-containing complex membrane membrane protein complex cell periphery plasma membrane transport vesicle intracellular vesicle endomembrane system cytoplasmic vesicle vesicle cytoplasmic vesicle membrane vesicle membrane organelle membrane basal dendrite somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection Golgi apparatus endosome Golgi membrane bounding membrane of organelle endoplasmic reticulum-Golgi intermediate compartment membrane endoplasmic reticulum-Golgi intermediate compartment cell body neuronal cell body apical dendrite endoplasmic reticulum

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR002088	Protein prenyltransferase, alpha subunit	Repeat
B	IPR001330	PFTB repeat	Repeat
B	IPR045089	Prenyltransferase subunit beta	Family
B	IPR026873	Geranylgeranyl transferase type-2 subunit beta	Family
B	IPR008930	Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid	Homologous Superfamily
C	IPR045848	YKT6, SNARE motif	Domain
C	IPR011012	Longin-like domain superfamily	Homologous Superfamily
C	IPR010908	Longin domain	Domain
C	IPR042855	v-SNARE, coiled-coil homology domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q7Z6K3	adrenal cortex carcinoma myopathy pancreatic intraductal papillary-mucinous carcinoma atypical teratoid rhabdoid tumor osteosarcoma pancreatic intraductal papillary-mucinous neoplasm malignant ependymoma ovarian cancer
B	Pharos: P53611	atypical teratoid rhabdoid tumor lung cancer ovarian cancer breast cancer medulloblastoma plasma cell myeloma dermatomyositis myopathy psoriasis
C	Pharos: O15498	carpal tunnel syndrome metabolic syndrome X psoriasis glioblastoma non-small cell lung carcinoma Sjogren syndrome lung cancer plasma cell myeloma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.