Annotations: 6JOW

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	EUF07802	e6jowA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Beta-galactosidase LacA beta-sandwich domain (From Topology)	T: Beta-galactosidase LacA beta-sandwich domain	F: EUF07802	ECOD (1.6)
A	EUF07813	e6jowA2	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: Glycosyl hydrolase domain (From Topology)	T: Glycosyl hydrolase domain	F: EUF07813	ECOD (1.6)
A	Glyco_hydro_42	e6jowA3	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glyco_hydro_42	ECOD (1.6)
A	Glyco_hydro_42M	e6jowA4	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Class I glutamine amidotransferase-like	F: Glyco_hydro_42M	ECOD (1.6)
B	EUF07802	e6jowB3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Beta-galactosidase LacA beta-sandwich domain (From Topology)	T: Beta-galactosidase LacA beta-sandwich domain	F: EUF07802	ECOD (1.6)
B	EUF07813	e6jowB2	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: Glycosyl hydrolase domain (From Topology)	T: Glycosyl hydrolase domain	F: EUF07813	ECOD (1.6)
B	Glyco_hydro_42	e6jowB1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glyco_hydro_42	ECOD (1.6)
B	Glyco_hydro_42M	e6jowB4	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Class I glutamine amidotransferase-like	F: Glyco_hydro_42M	ECOD (1.6)
C	EUF07802	e6jowC4	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Beta-galactosidase LacA beta-sandwich domain (From Topology)	T: Beta-galactosidase LacA beta-sandwich domain	F: EUF07802	ECOD (1.6)
C	EUF07813	e6jowC1	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: Glycosyl hydrolase domain (From Topology)	T: Glycosyl hydrolase domain	F: EUF07813	ECOD (1.6)
C	Glyco_hydro_42	e6jowC3	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glyco_hydro_42	ECOD (1.6)
C	Glyco_hydro_42M	e6jowC2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Class I glutamine amidotransferase-like	F: Glyco_hydro_42M	ECOD (1.6)
D	EUF07802	e6jowD4	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Beta-galactosidase LacA beta-sandwich domain (From Topology)	T: Beta-galactosidase LacA beta-sandwich domain	F: EUF07802	ECOD (1.6)
D	EUF07813	e6jowD2	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: Glycosyl hydrolase domain (From Topology)	T: Glycosyl hydrolase domain	F: EUF07813	ECOD (1.6)
D	Glyco_hydro_42	e6jowD3	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glyco_hydro_42	ECOD (1.6)
D	Glyco_hydro_42M	e6jowD1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Class I glutamine amidotransferase-like	F: Glyco_hydro_42M	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF02449	Beta-galactosidase (Glyco_hydro_42)	Beta-galactosidase	This group of beta-galactosidase enzymes belong to the glycosyl hydrolase 42 family. The enzyme catalyses the hydrolysis of terminal, non-reducing terminal beta-D-galactosidase residues.	Domain
A, B, C, D	PF08532	Beta-galactosidase trimerisation domain (Glyco_hydro_42M)	Beta-galactosidase trimerisation domain	This is non catalytic domain B of beta-galactosidase enzymes belong to the glycosyl hydrolase 42 family. This domain is related to glutamine amidotransferase enzymes, but the catalytic residues are replaced by non functional amino acids. This domain ...	This is non catalytic domain B of beta-galactosidase enzymes belong to the glycosyl hydrolase 42 family. This domain is related to glutamine amidotransferase enzymes, but the catalytic residues are replaced by non functional amino acids. This domain is involved in trimerisation [1].	Domain
A, B, C, D	PF22345	GLMA-like, C-terminal (GLMA-like_C)	GLMA-like, C-terminal	This entry represents a beta-sandwich domain found at the C-terminal of exo-beta-D-glucosaminidase GLMA from Thermococcus kodakarensis and similar archaeal proteins. It is an exo-type enzyme that specifically cleaves the non-reducing terminal glycosi ...	This entry represents a beta-sandwich domain found at the C-terminal of exo-beta-D-glucosaminidase GLMA from Thermococcus kodakarensis and similar archaeal proteins. It is an exo-type enzyme that specifically cleaves the non-reducing terminal glycosidic bond of chitooligosaccharides, being involved in chitin degradation [1-3].	Domain
A, B, C, D	PF22369	GLMA-like, glycosyl hydrolase domain (GLMA-like_GHD)	GLMA-like, glycosyl hydrolase domain	This entry represents an all-beta domain (GHD) found towards the C-terminal of exo-beta-D-glucosaminidase GLMA from Thermococcus kodakarensis and similar archaeal proteins, just before the C-terminal domain (Pfam:PF22345). It is an exo-type enzyme th ...	This entry represents an all-beta domain (GHD) found towards the C-terminal of exo-beta-D-glucosaminidase GLMA from Thermococcus kodakarensis and similar archaeal proteins, just before the C-terminal domain (Pfam:PF22345). It is an exo-type enzyme that specifically cleaves the non-reducing terminal glycosidic bond of chitooligosaccharides, being involved in chitin degradation [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Beta-galactosidase	hydrolase activity, acting on glycosyl bonds beta-galactosidase activity hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity catalytic activity galactosidase activity cation binding ion binding binding metal ion binding small molecule binding	carbohydrate metabolic process primary metabolic process metabolic process cellular process	protein-containing complex catalytic complex beta-galactosidase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR029062	Class I glutamine amidotransferase-like	Homologous Superfamily
A, B, C, D	IPR001944	Glycoside hydrolase, family 35	Family
A, B, C, D	IPR017853	Glycoside hydrolase superfamily	Homologous Superfamily
A, B, C, D	IPR053516	Exo-beta-D-glucosaminidase	Family
A, B, C, D	IPR013529	Glycoside hydrolase, family 42, N-terminal	Domain
A, B, C, D	IPR013738	Beta-galactosidase trimerisation	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.