Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ARVT_thumbe6kdmA2 A: alpha bundlesX: helical bundle domain in reverse transcriptase-like polymerases (From Topology)H: helical bundle domain in reverse transcriptase-like polymerases (From Topology)T: helical bundle domain in reverse transcriptase-like polymerasesF: RVT_thumbECOD (1.6)
ARVT_1e6kdmA3 A: a+b two layersX: Alpha-beta plaitsH: Adenylyl and guanylyl cyclase catalytic domain-likeT: Adenylyl and guanylyl cyclase catalytic domain-likeF: RVT_1ECOD (1.6)
ARNase_He6kdmA1 A: mixed a+b and a/bX: Ribonuclease H-likeH: Ribonuclease H-like (From Topology)T: Ribonuclease H-likeF: RNase_HECOD (1.6)
ARVT_connecte6kdmA4 A: mixed a+b and a/bX: Ribonuclease H-likeH: RNaseH-like domain in reverse transcriptase (From Topology)T: RNaseH-like domain in reverse transcriptaseF: RVT_connectECOD (1.6)
D [auth C]RVT_thumbe6kdmC1 A: alpha bundlesX: helical bundle domain in reverse transcriptase-like polymerases (From Topology)H: helical bundle domain in reverse transcriptase-like polymerases (From Topology)T: helical bundle domain in reverse transcriptase-like polymerasesF: RVT_thumbECOD (1.6)
D [auth C]RVT_1e6kdmC2 A: a+b two layersX: Alpha-beta plaitsH: Adenylyl and guanylyl cyclase catalytic domain-likeT: Adenylyl and guanylyl cyclase catalytic domain-likeF: RVT_1ECOD (1.6)
D [auth C]RNase_He6kdmC3 A: mixed a+b and a/bX: Ribonuclease H-likeH: Ribonuclease H-like (From Topology)T: Ribonuclease H-likeF: RNase_HECOD (1.6)
D [auth C]RVT_connecte6kdmC4 A: mixed a+b and a/bX: Ribonuclease H-likeH: RNaseH-like domain in reverse transcriptase (From Topology)T: RNaseH-like domain in reverse transcriptaseF: RVT_connectECOD (1.6)
BRVT_thumbe6kdmB3 A: alpha bundlesX: helical bundle domain in reverse transcriptase-like polymerases (From Topology)H: helical bundle domain in reverse transcriptase-like polymerases (From Topology)T: helical bundle domain in reverse transcriptase-like polymerasesF: RVT_thumbECOD (1.6)
BRVT_1e6kdmB1 A: a+b two layersX: Alpha-beta plaitsH: Adenylyl and guanylyl cyclase catalytic domain-likeT: Adenylyl and guanylyl cyclase catalytic domain-likeF: RVT_1ECOD (1.6)
BRVT_connecte6kdmB2 A: mixed a+b and a/bX: Ribonuclease H-likeH: RNaseH-like domain in reverse transcriptase (From Topology)T: RNaseH-like domain in reverse transcriptaseF: RVT_connectECOD (1.6)
E [auth D]RVT_thumbe6kdmD3 A: alpha bundlesX: helical bundle domain in reverse transcriptase-like polymerases (From Topology)H: helical bundle domain in reverse transcriptase-like polymerases (From Topology)T: helical bundle domain in reverse transcriptase-like polymerasesF: RVT_thumbECOD (1.6)
E [auth D]RVT_1e6kdmD1 A: a+b two layersX: Alpha-beta plaitsH: Adenylyl and guanylyl cyclase catalytic domain-likeT: Adenylyl and guanylyl cyclase catalytic domain-likeF: RVT_1ECOD (1.6)
E [auth D]RVT_connecte6kdmD2 A: mixed a+b and a/bX: Ribonuclease H-likeH: RNaseH-like domain in reverse transcriptase (From Topology)T: RNaseH-like domain in reverse transcriptaseF: RVT_connectECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A,
D [auth C]
PF06817Reverse transcriptase thumb domain (RVT_thumb)Reverse transcriptase thumb domainThis domain is known as the thumb domain. It is composed of a four helix bundle [1].Domain
A,
D [auth C]
PF06815Reverse transcriptase connection domain (RVT_connect)Reverse transcriptase connection domainThis domain is known as the connection domain. This domain lies between the thumb and palm domains [1].Domain
A,
D [auth C]
PF00075RNase H (RNase_H)RNase HRNase H digests the RNA strand of an RNA/DNA hybrid. Important enzyme in retroviral replication cycle, and often found as a domain associated with reverse transcriptases. Structure is a mixed alpha+beta fold with three a/b/a layers.Domain
A,
D [auth C]
PF00078Reverse transcriptase (RNA-dependent DNA polymerase) (RVT_1)Reverse transcriptase (RNA-dependent DNA polymerase)A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs ...A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs, hepadnaviruses, and caulimoviruses.
Domain
B,
E [auth D]
PF06817Reverse transcriptase thumb domain (RVT_thumb)Reverse transcriptase thumb domainThis domain is known as the thumb domain. It is composed of a four helix bundle [1].Domain
B,
E [auth D]
PF06815Reverse transcriptase connection domain (RVT_connect)Reverse transcriptase connection domainThis domain is known as the connection domain. This domain lies between the thumb and palm domains [1].Domain
B,
E [auth D]
PF00078Reverse transcriptase (RNA-dependent DNA polymerase) (RVT_1)Reverse transcriptase (RNA-dependent DNA polymerase)A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs ...A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs, hepadnaviruses, and caulimoviruses.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
C [auth E],
F
DNA/RNA (38-MER)---
A,
D [auth C]
HIV-1 reverse transcriptase p66 subunit
B,
E [auth D]
HIV-1 RT p51 subunit

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A,
D [auth C]
IPR036397Ribonuclease H superfamilyHomologous Superfamily
A,
D [auth C]
IPR043128Reverse transcriptase/Diguanylate cyclase domainHomologous Superfamily
A,
D [auth C]
IPR001995Peptidase A2A, retrovirus, catalyticDomain
A,
D [auth C]
IPR001878Zinc finger, CCHC-typeDomain
A,
D [auth C]
IPR008919Retrovirus capsid, N-terminalHomologous Superfamily
A,
D [auth C]
IPR012344Matrix protein, lentiviral and alpha-retroviral, N-terminalHomologous Superfamily
A,
D [auth C]
IPR036862Integrase, C-terminal domain superfamily, retroviralHomologous Superfamily
A,
D [auth C]
IPR018061RetropepsinsDomain
A,
D [auth C]
IPR010661Reverse transcriptase thumbDomain
A,
D [auth C]
IPR002156Ribonuclease H domainDomain
A,
D [auth C]
IPR036875Zinc finger, CCHC-type superfamilyHomologous Superfamily
A,
D [auth C]
IPR003308Integrase, N-terminal zinc-binding domainDomain
A,
D [auth C]
IPR001584Integrase, catalytic coreDomain
A,
D [auth C]
IPR045345Retroviral nucleocapsid Gag protein p24, C-terminal domainDomain
A,
D [auth C]
IPR010999Retroviral matrix proteinHomologous Superfamily
A,
D [auth C]
IPR021109Aspartic peptidase domain superfamilyHomologous Superfamily
A,
D [auth C]
IPR001969Aspartic peptidase, active siteActive Site
A,
D [auth C]
IPR012337Ribonuclease H-like superfamilyHomologous Superfamily
A,
D [auth C]
IPR017856Integrase-like, N-terminalHomologous Superfamily
A,
D [auth C]
IPR000071Immunodeficiency lentiviral matrix, N-terminalDomain
A,
D [auth C]
IPR043502DNA/RNA polymerase superfamilyHomologous Superfamily
A,
D [auth C]
IPR001037Integrase, C-terminal, retroviralDomain
A,
D [auth C]
IPR034170Retropepsin-like catalytic domainDomain
A,
D [auth C]
IPR000477Reverse transcriptase domainDomain
A,
D [auth C]
IPR010659Reverse transcriptase connectionDomain
A,
D [auth C]
IPR008916Retrovirus capsid, C-terminalHomologous Superfamily
B,
E [auth D]
IPR036397Ribonuclease H superfamilyHomologous Superfamily
B,
E [auth D]
IPR043128Reverse transcriptase/Diguanylate cyclase domainHomologous Superfamily
B,
E [auth D]
IPR001995Peptidase A2A, retrovirus, catalyticDomain
B,
E [auth D]
IPR001878Zinc finger, CCHC-typeDomain
B,
E [auth D]
IPR008919Retrovirus capsid, N-terminalHomologous Superfamily
B,
E [auth D]
IPR012344Matrix protein, lentiviral and alpha-retroviral, N-terminalHomologous Superfamily
B,
E [auth D]
IPR036862Integrase, C-terminal domain superfamily, retroviralHomologous Superfamily
B,
E [auth D]
IPR018061RetropepsinsDomain
B,
E [auth D]
IPR010661Reverse transcriptase thumbDomain
B,
E [auth D]
IPR002156Ribonuclease H domainDomain
B,
E [auth D]
IPR036875Zinc finger, CCHC-type superfamilyHomologous Superfamily
B,
E [auth D]
IPR003308Integrase, N-terminal zinc-binding domainDomain
B,
E [auth D]
IPR001584Integrase, catalytic coreDomain
B,
E [auth D]
IPR045345Retroviral nucleocapsid Gag protein p24, C-terminal domainDomain
B,
E [auth D]
IPR010999Retroviral matrix proteinHomologous Superfamily
B,
E [auth D]
IPR021109Aspartic peptidase domain superfamilyHomologous Superfamily
B,
E [auth D]
IPR001969Aspartic peptidase, active siteActive Site
B,
E [auth D]
IPR012337Ribonuclease H-like superfamilyHomologous Superfamily
B,
E [auth D]
IPR017856Integrase-like, N-terminalHomologous Superfamily
B,
E [auth D]
IPR000071Immunodeficiency lentiviral matrix, N-terminalDomain
B,
E [auth D]
IPR043502DNA/RNA polymerase superfamilyHomologous Superfamily
B,
E [auth D]
IPR001037Integrase, C-terminal, retroviralDomain
B,
E [auth D]
IPR034170Retropepsin-like catalytic domainDomain
B,
E [auth D]
IPR000477Reverse transcriptase domainDomain
B,
E [auth D]
IPR010659Reverse transcriptase connectionDomain
B,
E [auth D]
IPR008916Retrovirus capsid, C-terminalHomologous Superfamily