6O0W

Crystal structure of the TIR domain from the grapevine disease resistance protein RUN1 in complex with NADP+ and Bis-Tris

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	TIR	e6o0wA1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Toll/Interleukin receptor TIR domain (From Topology)	T: Toll/Interleukin receptor TIR domain	F: TIR	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.10140	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Toll/interleukin-1 receptor homology (TIR) domain	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01582	TIR domain (TIR)	TIR domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	TIR-NB-LRR type resistance protein RUN1	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding nucleoside phosphate binding ion binding ADP binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding nucleoside phosphate binding ion binding ADP binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding hydrolase activity, acting on glycosyl bonds hydrolase activity NAD+ nucleotidase, cyclic ADP-ribose generating hydrolase activity, hydrolyzing N-glycosyl compounds catalytic activity NAD+ nucleosidase activity NADP+ nucleosidase activity	biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus response to biotic stimulus defense response to fungus defense response to other organism response to stress response to external biotic stimulus response to fungus regulation of biological process positive regulation of programmed cell death regulation of cellular process biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus response to biotic stimulus defense response to fungus defense response to other organism response to stress response to external biotic stimulus response to fungus regulation of biological process positive regulation of programmed cell death regulation of cellular process biological regulation positive regulation of biological process cellular process regulation of programmed cell death cell death programmed cell death positive regulation of cellular process pyridine nucleotide catabolic process catabolic process organophosphate catabolic process nucleoside phosphate catabolic process NAD metabolic process nucleobase-containing compound metabolic process NAD catabolic process purine nucleotide metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process pyridine-containing compound metabolic process small molecule metabolic process phosphorus metabolic process pyridine nucleotide metabolic process nucleotide catabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process purine nucleotide catabolic process primary metabolic process purine-containing compound catabolic process nucleotide metabolic process nucleobase-containing compound catabolic process purine-containing compound metabolic process organophosphate metabolic process metabolic process pyridine-containing compound catabolic process cellular response to stimulus signaling signal transduction cell communication	cellular anatomical structure intracellular anatomical structure cytoplasm membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR025875	Leucine rich repeat 4	Repeat
A	IPR000157	Toll/interleukin-1 receptor homology (TIR) domain	Domain
A	IPR045344	C-JID domain	Domain
A	IPR042197	Apoptotic protease-activating factors, helical domain	Homologous Superfamily
A	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
A	IPR003591	Leucine-rich repeat, typical subtype	Repeat
A	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
A	IPR035897	Toll/interleukin-1 receptor homology (TIR) domain superfamily	Homologous Superfamily
A	IPR044974	Disease resistance protein, plants	Family
A	IPR002182	NB-ARC	Domain
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.