Annotations: 6OV0

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	UNK_F_TYPE	e6ov0A2	A: alpha bundles	X: Four-helical up-and-down bundle	H: HEPN	T: HEPN domain in CRISPR-associated protein Csx1	F: UNK_F_TYPE	ECOD (1.6)
A	Cas_DxTHG	e6ov0A1	A: a/b three-layered sandwiches	X: CARF (CRISPR-associated Rossmann fold) domains (From Topology)	H: CARF (CRISPR-associated Rossmann fold) domains (From Topology)	T: CARF (CRISPR-associated Rossmann fold) domains	F: Cas_DxTHG	ECOD (1.6)
B	UNK_F_TYPE	e6ov0B2	A: alpha bundles	X: Four-helical up-and-down bundle	H: HEPN	T: HEPN domain in CRISPR-associated protein Csx1	F: UNK_F_TYPE	ECOD (1.6)
B	Cas_DxTHG	e6ov0B1	A: a/b three-layered sandwiches	X: CARF (CRISPR-associated Rossmann fold) domains (From Topology)	H: CARF (CRISPR-associated Rossmann fold) domains (From Topology)	T: CARF (CRISPR-associated Rossmann fold) domains	F: Cas_DxTHG	ECOD (1.6)
C	UNK_F_TYPE	e6ov0C2	A: alpha bundles	X: Four-helical up-and-down bundle	H: HEPN	T: HEPN domain in CRISPR-associated protein Csx1	F: UNK_F_TYPE	ECOD (1.6)
C	Cas_DxTHG	e6ov0C1	A: a/b three-layered sandwiches	X: CARF (CRISPR-associated Rossmann fold) domains (From Topology)	H: CARF (CRISPR-associated Rossmann fold) domains (From Topology)	T: CARF (CRISPR-associated Rossmann fold) domains	F: Cas_DxTHG	ECOD (1.6)
D	UNK_F_TYPE	e6ov0D2	A: alpha bundles	X: Four-helical up-and-down bundle	H: HEPN	T: HEPN domain in CRISPR-associated protein Csx1	F: UNK_F_TYPE	ECOD (1.6)
D	Cas_DxTHG	e6ov0D1	A: a/b three-layered sandwiches	X: CARF (CRISPR-associated Rossmann fold) domains (From Topology)	H: CARF (CRISPR-associated Rossmann fold) domains (From Topology)	T: CARF (CRISPR-associated Rossmann fold) domains	F: Cas_DxTHG	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF22230	CRISPR system endoribonuclease Csx1, CARF domain (Csx1_CARF)	CRISPR system endoribonuclease Csx1, CARF domain	CRISPR system endoribonuclease Csx1 is a metal-independent, endoribonuclease that acts selectively on ssRNA and cleaves specifically after adenosines, as part of the type III-B CRISP-Cas system and it is homologous to Csm6 [1-3], sharing the same dom ...	CRISPR system endoribonuclease Csx1 is a metal-independent, endoribonuclease that acts selectively on ssRNA and cleaves specifically after adenosines, as part of the type III-B CRISP-Cas system and it is homologous to Csm6 [1-3], sharing the same domain domain architecture consisting of a CARF domain at the N-terminal that is relatively well conserved, and a HEPN nuclease domain at the C-terminal. This entry represents the CARF (CRISPR-associated Rossmann fold) domain, which binds and cleaves the cyclic oligoadenylate molecule (cA) that then activates the HEPN domain.	Domain

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR052875	CRISPR-associated endoribonuclease	Family
A, B, C, D	IPR010171	CRISPR system endoribonuclease Csx1	Family
A, B, C, D	IPR053857	CRISPR system endoribonuclease Csx1, CARF domain	Domain
A, B, C, D	IPR013383	CRISPR-associated protein DxTHG, conserved site	Conserved Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.