6PDE

Crystal structure of MYST acetyltransferase domain in complex with inhibitor 40

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6pdea_	Alpha and beta proteins (a+b)	Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	beta-beta-alpha zinc fingers	8091459	3001077	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Acyl-CoA N-acyltransferases (Nat)	8041913	3000403	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	MOZ_SAS_C	e6pdeA1	A: alpha arrays	X: HTH	H: HTH	T: HAT1, C-terminal domain	F: MOZ_SAS_C	ECOD (1.6)
A	MOZ_SAS_N	e6pdeA3	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: MOZ_SAS_N	ECOD (1.6)
A	PLN00104	e6pdeA2	A: few secondary structure elements	X: beta-beta-alpha zinc fingers	H: beta-beta-alpha zinc fingers (From Topology)	T: beta-beta-alpha zinc fingers	F: PLN00104	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF17772	MYST family zinc finger domain (zf-MYST)	MYST family zinc finger domain	This zinc finger domain is found in the MYST family of histone acetyltransferases [1].	Domain
A	PF01853	MOZ/SAS family (MOZ_SAS)	MOZ/SAS family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Histone acetyltransferase KAT8	transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding binding DNA-binding transcription factor binding catalytic activity, acting on a protein N-acetyltransferase activity acyltransferase activity histone H4 acetyltransferase activity transferase activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding binding DNA-binding transcription factor binding catalytic activity, acting on a protein N-acetyltransferase activity acyltransferase activity histone H4 acetyltransferase activity transferase activity peptide N-acetyltransferase activity histone acetyltransferase activity acetyltransferase activity peptide-lysine-N-acetyltransferase activity histone modifying activity histone H4K8 acetyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups catalytic activity N-acyltransferase activity chromatin binding transcription coactivator activity histone H4K5 acetyltransferase activity protein propionyltransferase activity histone H4K16 acetyltransferase activity enzyme binding cation binding ion binding metal ion binding small molecule binding	regulation of cellular process cellular biosynthetic process negative regulation of biological process RNA metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of cellular process cellular biosynthetic process negative regulation of biological process RNA metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process negative regulation of metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process multicellular organismal process negative regulation of type I interferon production cytokine production regulation of cytokine production regulation of multicellular organismal process type I interferon production negative regulation of cytokine production negative regulation of gene expression negative regulation of multicellular organismal process regulation of type I interferon production positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of gene expression, epigenetic cellular component organization positive regulation of metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process chromatin organization chromatin remodeling positive regulation of macromolecule metabolic process cellular component organization or biogenesis positive regulation of cellular process transcription initiation at RNA polymerase II promoter epigenetic regulation of gene expression DNA-templated transcription initiation positive regulation of gene expression transcription initiation-coupled chromatin remodeling positive regulation of cellular biosynthetic process developmental process neurogenesis multicellular organism development cellular developmental process cell differentiation anatomical structure development nervous system development system development sexual reproduction reproductive process oogenesis multicellular organismal reproductive process cell development cellular process involved in reproduction in multicellular organism female gamete generation developmental process involved in reproduction gamete generation germ cell development skeletal muscle cell differentiation regulation of developmental process skeletal muscle tissue development regulation of cell differentiation positive regulation of skeletal muscle satellite cell differentiation striated muscle tissue development muscle structure development positive regulation of developmental process skeletal muscle organ development regulation of skeletal muscle cell differentiation positive regulation of cell differentiation positive regulation of skeletal muscle cell differentiation muscle tissue development muscle organ development animal organ development tissue development skeletal muscle satellite cell differentiation regulation of DNA-templated transcription initiation regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of transcription initiation by RNA polymerase II positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II regulation of mitochondrial transcription regulation of mitochondrial gene expression mitochondrial gene expression mitochondrial transcription mitochondrial RNA metabolic process hemopoiesis post-embryonic development post-embryonic hemopoiesis regulation of epithelial to mesenchymal transition mesenchyme development negative regulation of cell differentiation negative regulation of developmental process negative regulation of epithelial to mesenchymal transition epithelial to mesenchymal transition mesenchymal cell differentiation mRNA processing RNA processing regulation of mRNA processing mRNA metabolic process regulation of mRNA metabolic process catabolic process autophagy regulation of catabolic process regulation of autophagy cellular catabolic process regulation of cellular catabolic process process utilizing autophagic mechanism myeloid cell differentiation	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex catalytic complex chromatin chromosome transferase complex histone acetyltransferase complex membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex catalytic complex chromatin chromosome transferase complex histone acetyltransferase complex acetyltransferase complex intracellular non-membrane-bounded organelle protein acetyltransferase complex intracellular protein-containing complex non-membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen organelle lumen nuclear periphery nuclear lumen nuclear matrix MSL complex H4 histone acetyltransferase complex NuA4 histone acetyltransferase complex H4/H2A histone acetyltransferase complex nucleoplasm NSL complex chromosomal region kinetochore chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome histone methyltransferase complex nuclear protein-containing complex MLL1/2 complex MLL1 complex methyltransferase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR002717	Histone acetyltransferase domain, MYST-type	Domain
A	IPR016197	Chromo-like domain superfamily	Homologous Superfamily
A	IPR050603	MYST family histone acetyltransferases	Family
A	IPR000953	Chromo/chromo shadow domain	Domain
A	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A	IPR025995	RNA binding activity-knot of a chromodomain	Domain
A	IPR016181	Acyl-CoA N-acyltransferase	Homologous Superfamily
A	IPR040706	MYST, zinc finger domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9H7Z6	congestive heart failure hypertrophic cardiomyopathy Heart Decompensation psoriasis Graves disease heart failure osteosarcoma schizophrenia Hashimoto thyroiditis malignant mesothelioma ovarian cancer

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A	ALY	Parent Component: LYS RESID: AA0055 PSI-MOD : N6-acetyl-L-lysine MOD:00064

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.