6PF4
Crystal structure of human thymidylate synthase Delta (7-29) in complex with dUMP and 2-(2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)phenyl)acetic acid
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
D | SCOP2B Superfamily | Thymidylate synthase/dCMP hydroxymethylase | 8036156 | 3000544 | SCOP2B (2022-06-29) |
A [auth B] | SCOP2B Superfamily | Thymidylate synthase/dCMP hydroxymethylase | 8036156 | 3000544 | SCOP2B (2022-06-29) |
B [auth A] | SCOP2B Superfamily | Thymidylate synthase/dCMP hydroxymethylase | 8036156 | 3000544 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | Thymidylate synthase/dCMP hydroxymethylase | 8036156 | 3000544 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
D | Thymidylat_synt | e6pf4D1 | A: a+b two layers | X: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | H: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | T: Thymidylate synthase/dCMP hydroxymethylase | F: Thymidylat_synt | ECOD (1.6) |
A [auth B] | Thymidylat_synt | e6pf4B1 | A: a+b two layers | X: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | H: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | T: Thymidylate synthase/dCMP hydroxymethylase | F: Thymidylat_synt | ECOD (1.6) |
B [auth A] | Thymidylat_synt | e6pf4A1 | A: a+b two layers | X: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | H: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | T: Thymidylate synthase/dCMP hydroxymethylase | F: Thymidylat_synt | ECOD (1.6) |
C | Thymidylat_synt | e6pf4C1 | A: a+b two layers | X: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | H: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | T: Thymidylate synthase/dCMP hydroxymethylase | F: Thymidylat_synt | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
D | 3.30.572.10 | Alpha Beta | 2-Layer Sandwich | Thymidylate Synthase | Chain A | CATH (utative) |
A [auth B] | 3.30.572.10 | Alpha Beta | 2-Layer Sandwich | Thymidylate Synthase | Chain A | CATH (utative) |
B [auth A] | 3.30.572.10 | Alpha Beta | 2-Layer Sandwich | Thymidylate Synthase | Chain A | CATH (utative) |
C | 3.30.572.10 | Alpha Beta | 2-Layer Sandwich | Thymidylate Synthase | Chain A | CATH (utative) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
A [auth B], B [auth A], C, D | PF00303 | Thymidylate synthase (Thymidylat_synt) | Thymidylate synthase | This is a family of proteins that are flavin-dependent thymidylate synthases. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
A [auth B], B [auth A], C, D | IPR036926 | Thymidylate synthase/dCMP hydroxymethylase superfamily | Homologous Superfamily |
A [auth B], B [auth A], C, D | IPR000398 | Thymidylate synthase | Family |
A [auth B], B [auth A], C, D | IPR020940 | Thymidylate synthase, active site | Active Site |
A [auth B], B [auth A], C, D | IPR023451 | Thymidylate synthase/dCMP hydroxymethylase domain | Domain |
A [auth B], B [auth A], C, D | IPR045097 | Thymidylate synthase/dCMP hydroxymethylase | Family |