Annotations: 6R4E

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	GATase_2_1st	e6r4eA1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Class II glutamine amidotransferases	F: GATase_2_1st	ECOD (1.6)
A	SIS_3	e6r4eA3	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Ribosomal protein S2/SIS domain (From Topology)	T: Ribosomal protein S2/SIS domain	F: SIS_3	ECOD (1.6)
B	GATase_2_1st	e6r4eB1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Class II glutamine amidotransferases	F: GATase_2_1st	ECOD (1.6)
B	SIS_3	e6r4eB3	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Ribosomal protein S2/SIS domain (From Topology)	T: Ribosomal protein S2/SIS domain	F: SIS_3	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01380	SIS domain (SIS)	SIS domain	SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domain ...	SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.	Domain
A, B	PF13522	Glutamine amidotransferase domain (GATase_6)	Glutamine amidotransferase domain	This domain is a class-II glutamine amidotransferase domain found in a variety of enzymes, such as asparagine synthetase and glutamine--fructose-6-phosphate transaminase.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1	binding carbohydrate derivative binding transferase activity, transferring nitrogenous groups glutamine-fructose-6-phosphate transaminase (isomerizing) activity L-glutamine aminotransferase activity transaminase activity transferase activity catalytic activity	carbohydrate derivative biosynthetic process cellular biosynthetic process cellular metabolic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein N-linked glycosylation protein glycosylation macromolecule biosynthetic process biosynthetic process glycosylation macromolecule modification macromolecule glycosylation carbohydrate derivative biosynthetic process cellular biosynthetic process cellular metabolic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein N-linked glycosylation protein glycosylation macromolecule biosynthetic process biosynthetic process glycosylation macromolecule modification macromolecule glycosylation metabolic process cellular process protein metabolic process macromolecule metabolic process protein modification process organophosphate metabolic process phosphate-containing compound metabolic process fructose 6-phosphate metabolic process phosphorus metabolic process nucleoside phosphate metabolic process nucleotide-sugar metabolic process nucleobase-containing compound metabolic process nucleobase-containing small molecule metabolic process amino sugar metabolic process small molecule metabolic process UDP-N-acetylglucosamine metabolic process amino sugar biosynthetic process UDP-N-acetylglucosamine biosynthetic process nucleotide-sugar biosynthetic process nucleobase-containing compound biosynthetic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process glutamine metabolic process oxoacid metabolic process carboxylic acid metabolic process amino acid metabolic process organic acid metabolic process alpha-amino acid metabolic process L-amino acid metabolic process glutamine family amino acid metabolic process proteinogenic amino acid metabolic process energy derivation by oxidation of organic compounds energy reserve metabolic process generation of precursor metabolites and energy regulation of biosynthetic process rhythmic process regulation of biological process regulation of cellular process circadian regulation of gene expression circadian rhythm biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression regulation of cellular biosynthetic process regulation of gene expression regulation of macromolecule biosynthetic process regulation of metabolic process	extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR046348	SIS domain superfamily	Homologous Superfamily
A, B	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
A, B	IPR035466	GlmS/AgaS, SIS domain 1	Domain
A, B	IPR005855	Glucosamine-fructose-6-phosphate aminotransferase, isomerising	Family
A, B	IPR035490	GlmS/FrlB, SIS domain 2	Domain
A, B	IPR017932	Glutamine amidotransferase type 2 domain	Domain
A, B	IPR047084	Glucosamine-fructose-6-phosphate aminotransferase, isomerising, N-terminal domain	Domain
A, B	IPR001347	SIS domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q06210	congenital myasthenic syndrome obesity disorder congenital myasthenic syndrome 12 medulloblastoma Myasthenic syndrome, congenital, type Id pancreatic intraductal papillary-mucinous carcinoma adrenoleukodystrophy peripheral nervous system disease breast cancer tuberculosis gastric cancer invasive ductal breast carcinoma lung carcinoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm congenital myasthenic syndrome obesity disorder congenital myasthenic syndrome 12 medulloblastoma Myasthenic syndrome, congenital, type Id pancreatic intraductal papillary-mucinous carcinoma adrenoleukodystrophy peripheral nervous system disease breast cancer tuberculosis gastric cancer invasive ductal breast carcinoma lung carcinoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm arthrogryposis peripheral neuropathy congenital disorder of glycosylation congenital myasthenic syndrome 4C dental caries gastric carcinoma juvenile dermatomyositis malignant pancreatic neoplasm non-small cell lung carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Barrett esophagus psoriasis exocrine pancreatic carcinoma hepatocellular carcinoma lung adenocarcinoma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A, B	SEP	Parent Component: SER RESID: AA0037 PSI-MOD : O-phospho-L-serine MOD:00046

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.