Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AMmgE_PrpD_1ste6r6tA2 A: alpha arraysX: alpha-helical domain in 2-methylcitrate dehydratase PrpD (From Topology)H: alpha-helical domain in 2-methylcitrate dehydratase PrpD (From Topology)T: alpha-helical domain in 2-methylcitrate dehydratase PrpDF: MmgE_PrpD_1stECOD (1.6)
AMmgE_PrpD_2nde6r6tA1 A: a+b two layersX: FwdE/GAPDH domain-likeH: Serine dehydratase beta chain-like (From Topology)T: Serine dehydratase beta chain-likeF: MmgE_PrpD_2ndECOD (1.6)
BMmgE_PrpD_1ste6r6tB1 A: alpha arraysX: alpha-helical domain in 2-methylcitrate dehydratase PrpD (From Topology)H: alpha-helical domain in 2-methylcitrate dehydratase PrpD (From Topology)T: alpha-helical domain in 2-methylcitrate dehydratase PrpDF: MmgE_PrpD_1stECOD (1.6)
BMmgE_PrpD_2nde6r6tB2 A: a+b two layersX: FwdE/GAPDH domain-likeH: Serine dehydratase beta chain-like (From Topology)T: Serine dehydratase beta chain-likeF: MmgE_PrpD_2ndECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF19305MmgE/PrpD C-terminal domain (MmgE_PrpD_C)MmgE/PrpD C-terminal domainThis entry represents the C-terminal domain of 2-methylcitrate dehydratase EC:4.2.1.79 (PrpD) that is required for propionate catabolism. It catalyses the third step of the 2-methylcitric acid cycle. This domain is related to the serine dehydratase b ...This entry represents the C-terminal domain of 2-methylcitrate dehydratase EC:4.2.1.79 (PrpD) that is required for propionate catabolism. It catalyses the third step of the 2-methylcitric acid cycle. This domain is related to the serine dehydratase beta chain.
Domain
A, B
PF03972MmgE/PrpD N-terminal domain (MmgE_PrpD_N)MmgE/PrpD N-terminal domainThis entry represents the N-terminal domain of 2-methylcitrate dehydratase EC:4.2.1.79 (PrpD) that is required for propionate catabolism. It catalyses the third step of the 2-methylcitric acid cycle [1]. This enzyme consists of two domains: a large d ...This entry represents the N-terminal domain of 2-methylcitrate dehydratase EC:4.2.1.79 (PrpD) that is required for propionate catabolism. It catalyses the third step of the 2-methylcitric acid cycle [1]. This enzyme consists of two domains: a large domain with an all-helical fold and a smaller domain that folds into an alpha/beta domain [2]. Cis-aconitic acid decarboxylase (CAD) shares high identity with proteins of the MmgE/PrpD family [3,4]. Citrate/2-methylcitrate dehydratase from Bacillus subtilis is involved in the tricarboxylic acid (TCA) and methylcitric acid cycles as it has both 2-methylcitrate dehydratase and citrate dehydratase activities [5]. This entry represents the N-terminal domain of 2-methylcitrate dehydratase PrpD, which has an all-helical fold.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
Cis-aconitate decarboxylase

InterPro: Protein Family Classification InterPro Database Homepage