6SMT

S-enantioselective imine reductase from Mycobacterium smegmatis

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	MmsB_like	e6smtA1	A: alpha arrays	X: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)	H: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)	T: 6-phosphogluconate dehydrogenase C-terminal domain-like	F: MmsB_like	ECOD (1.6)
A	NAD_binding_2	e6smtA2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: NAD_binding_2	ECOD (1.6)
B	MmsB_like	e6smtB1	A: alpha arrays	X: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)	H: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)	T: 6-phosphogluconate dehydrogenase C-terminal domain-like	F: MmsB_like	ECOD (1.6)
B	NAD_binding_2	e6smtB2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: NAD_binding_2	ECOD (1.6)
C	MmsB_like	e6smtC1	A: alpha arrays	X: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)	H: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)	T: 6-phosphogluconate dehydrogenase C-terminal domain-like	F: MmsB_like	ECOD (1.6)
C	NAD_binding_2	e6smtC2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: NAD_binding_2	ECOD (1.6)
D	MmsB_like	e6smtD1	A: alpha arrays	X: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)	H: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)	T: 6-phosphogluconate dehydrogenase C-terminal domain-like	F: MmsB_like	ECOD (1.6)
D	NAD_binding_2	e6smtD2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: NAD_binding_2	ECOD (1.6)
E	MmsB_like	e6smtE1	A: alpha arrays	X: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)	H: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)	T: 6-phosphogluconate dehydrogenase C-terminal domain-like	F: MmsB_like	ECOD (1.6)
E	NAD_binding_2	e6smtE2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: NAD_binding_2	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E	PF21761	NADPH-dependent reductive aminase-like, C-terminal domain (RedAm-like_C)	NADPH-dependent reductive aminase-like, C-terminal domain	This domain is found at the C-terminal end of NADPH-dependent reductive aminase from Aspergillus oryzae (RedAm) and similar proteins predominantly found in fungi and bacteria. RedAm catalyses the reductive coupling of a broad set of carbonyl compound ...	This domain is found at the C-terminal end of NADPH-dependent reductive aminase from Aspergillus oryzae (RedAm) and similar proteins predominantly found in fungi and bacteria. RedAm catalyses the reductive coupling of a broad set of carbonyl compounds with a variety of primary and secondary amines. This protein folds into an N-terminal Rossman domain (Pfam:PF03446) and a C-terminal helical bundle (this entry) connected by a long inter-domain alpha-helix [3].	Domain
A, B, C, D, E	PF03446	NAD binding domain of 6-phosphogluconate dehydrogenase (NAD_binding_2)	NAD binding domain of 6-phosphogluconate dehydrogenase	The NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E	6-phosphogluconate dehydrogenase, NAD-binding	oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors catalytic activity binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding adenyl nucleotide binding nucleotide binding heterocyclic compound binding NADP binding small molecule binding	cellular catabolic process catabolic process small molecule metabolic process metabolic process cellular process organic acid catabolic process organic acid metabolic process small molecule catabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E	IPR015815	3-hydroxyisobutyrate dehydrogenase-related	Family
A, B, C, D, E	IPR048666	NADPH-dependent reductive aminase-like, C-terminal domain	Domain
A, B, C, D, E	IPR006115	6-phosphogluconate dehydrogenase, NADP-binding	Domain
A, B, C, D, E	IPR051265	HIBADH-related NP60 subfamily	Family
A, B, C, D, E	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
A, B, C, D, E	IPR013328	6-phosphogluconate dehydrogenase, domain 2	Homologous Superfamily
A, B, C, D, E	IPR008927	6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.