6TGE

NADP dependent methylene-tetrahydromethanopterin dehydrogenase-NADP+-methenyl-H4MPT+ complex

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	MtdA-like	8001046	3000046	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	MtdA-like	8001046	3000046	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	MtdA-like	8001046	3000046	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	MtdA-like	8001046	3000046	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	MtdA-like	8001046	3000046	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	MtdA-like	8001046	3000046	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	MtdA-like	8001046	3000046	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	MtdA-like	8001046	3000046	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	MtdA-like	8001046	3000046	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	MtdA-like	8001046	3000046	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	MtdA-like	8001046	3000046	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	MtdA-like	8001046	3000046	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	MtdA-like	8001046	3000046	SCOP2B (2022-06-29)
Q	SCOP2B Superfamily	MtdA-like	8001046	3000046	SCOP2B (2022-06-29)
R	SCOP2B Superfamily	MtdA-like	8001046	3000046	SCOP2B (2022-06-29)
T	SCOP2B Superfamily	MtdA-like	8001046	3000046	SCOP2B (2022-06-29)
U	SCOP2B Superfamily	MtdA-like	8001046	3000046	SCOP2B (2022-06-29)
V	SCOP2B Superfamily	MtdA-like	8001046	3000046	SCOP2B (2022-06-29)
W	SCOP2B Superfamily	MtdA-like	8001046	3000046	SCOP2B (2022-06-29)
X	SCOP2B Superfamily	MtdA-like	8001046	3000046	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	MtdA-like	8001046	3000046	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	MtdA-like	8001046	3000046	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	MtdA-like	8001046	3000046	SCOP2B (2022-06-29)
S	SCOP2B Superfamily	MtdA-like	8001046	3000046	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	NAD_binding_10	e6tgeA1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: NAD_binding_10	ECOD (1.6)
A	Mpt_N	e6tgeA2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Aminoacid dehydrogenase-like, N-terminal domain	F: Mpt_N	ECOD (1.6)
B	NAD_binding_10	e6tgeB2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: NAD_binding_10	ECOD (1.6)
B	Mpt_N	e6tgeB1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Aminoacid dehydrogenase-like, N-terminal domain	F: Mpt_N	ECOD (1.6)
C	NAD_binding_10	e6tgeC1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: NAD_binding_10	ECOD (1.6)
C	Mpt_N	e6tgeC2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Aminoacid dehydrogenase-like, N-terminal domain	F: Mpt_N	ECOD (1.6)
D	NAD_binding_10	e6tgeD2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: NAD_binding_10	ECOD (1.6)
D	Mpt_N	e6tgeD1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Aminoacid dehydrogenase-like, N-terminal domain	F: Mpt_N	ECOD (1.6)
E	NAD_binding_10	e6tgeE1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: NAD_binding_10	ECOD (1.6)
E	Mpt_N	e6tgeE2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Aminoacid dehydrogenase-like, N-terminal domain	F: Mpt_N	ECOD (1.6)
F	NAD_binding_10	e6tgeF2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: NAD_binding_10	ECOD (1.6)
F	Mpt_N	e6tgeF1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Aminoacid dehydrogenase-like, N-terminal domain	F: Mpt_N	ECOD (1.6)
H	NAD_binding_10	e6tgeH2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: NAD_binding_10	ECOD (1.6)
H	Mpt_N	e6tgeH1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Aminoacid dehydrogenase-like, N-terminal domain	F: Mpt_N	ECOD (1.6)
I	NAD_binding_10	e6tgeI1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: NAD_binding_10	ECOD (1.6)
I	Mpt_N	e6tgeI2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Aminoacid dehydrogenase-like, N-terminal domain	F: Mpt_N	ECOD (1.6)
K	NAD_binding_10	e6tgeK2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: NAD_binding_10	ECOD (1.6)
K	Mpt_N	e6tgeK1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Aminoacid dehydrogenase-like, N-terminal domain	F: Mpt_N	ECOD (1.6)
L	NAD_binding_10	e6tgeL1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: NAD_binding_10	ECOD (1.6)
L	Mpt_N	e6tgeL2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Aminoacid dehydrogenase-like, N-terminal domain	F: Mpt_N	ECOD (1.6)
M	NAD_binding_10	e6tgeM2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: NAD_binding_10	ECOD (1.6)
M	Mpt_N	e6tgeM1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Aminoacid dehydrogenase-like, N-terminal domain	F: Mpt_N	ECOD (1.6)
N	NAD_binding_10	e6tgeN2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: NAD_binding_10	ECOD (1.6)
N	Mpt_N	e6tgeN1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Aminoacid dehydrogenase-like, N-terminal domain	F: Mpt_N	ECOD (1.6)
P	NAD_binding_10	e6tgeP1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: NAD_binding_10	ECOD (1.6)
P	Mpt_N	e6tgeP2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Aminoacid dehydrogenase-like, N-terminal domain	F: Mpt_N	ECOD (1.6)
Q	NAD_binding_10	e6tgeQ1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: NAD_binding_10	ECOD (1.6)
Q	Mpt_N	e6tgeQ2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Aminoacid dehydrogenase-like, N-terminal domain	F: Mpt_N	ECOD (1.6)
R	NAD_binding_10	e6tgeR2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: NAD_binding_10	ECOD (1.6)
R	Mpt_N	e6tgeR1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Aminoacid dehydrogenase-like, N-terminal domain	F: Mpt_N	ECOD (1.6)
T	NAD_binding_10	e6tgeT2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: NAD_binding_10	ECOD (1.6)
T	Mpt_N	e6tgeT1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Aminoacid dehydrogenase-like, N-terminal domain	F: Mpt_N	ECOD (1.6)
U	NAD_binding_10	e6tgeU1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: NAD_binding_10	ECOD (1.6)
U	Mpt_N	e6tgeU2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Aminoacid dehydrogenase-like, N-terminal domain	F: Mpt_N	ECOD (1.6)
V	NAD_binding_10	e6tgeV2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: NAD_binding_10	ECOD (1.6)
V	Mpt_N	e6tgeV1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Aminoacid dehydrogenase-like, N-terminal domain	F: Mpt_N	ECOD (1.6)
W	NAD_binding_10	e6tgeW2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: NAD_binding_10	ECOD (1.6)
W	Mpt_N	e6tgeW1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Aminoacid dehydrogenase-like, N-terminal domain	F: Mpt_N	ECOD (1.6)
X	NAD_binding_10	e6tgeX2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: NAD_binding_10	ECOD (1.6)
X	Mpt_N	e6tgeX1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Aminoacid dehydrogenase-like, N-terminal domain	F: Mpt_N	ECOD (1.6)
G	NAD_binding_10	e6tgeG1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: NAD_binding_10	ECOD (1.6)
G	Mpt_N	e6tgeG2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Aminoacid dehydrogenase-like, N-terminal domain	F: Mpt_N	ECOD (1.6)
J	NAD_binding_10	e6tgeJ2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: NAD_binding_10	ECOD (1.6)
J	Mpt_N	e6tgeJ1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Aminoacid dehydrogenase-like, N-terminal domain	F: Mpt_N	ECOD (1.6)
O	NAD_binding_10	e6tgeO1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: NAD_binding_10	ECOD (1.6)
O	Mpt_N	e6tgeO2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Aminoacid dehydrogenase-like, N-terminal domain	F: Mpt_N	ECOD (1.6)
S	NAD_binding_10	e6tgeS2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: NAD_binding_10	ECOD (1.6)
S	Mpt_N	e6tgeS1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Aminoacid dehydrogenase-like, N-terminal domain	F: Mpt_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.10280	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal domain	CATH (utative)
A	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (utative)
B	3.40.50.10280	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal domain	CATH (utative)
B	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (utative)
C	3.40.50.10280	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal domain	CATH (utative)
C	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (utative)
D	3.40.50.10280	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal domain	CATH (utative)
D	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (utative)
E	3.40.50.10280	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal domain	CATH (utative)
E	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (utative)
F	3.40.50.10280	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal domain	CATH (utative)
F	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (utative)
H	3.40.50.10280	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal domain	CATH (utative)
H	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (utative)
I	3.40.50.10280	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal domain	CATH (utative)
I	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (utative)
K	3.40.50.10280	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal domain	CATH (utative)
K	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (utative)
L	3.40.50.10280	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal domain	CATH (utative)
L	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (utative)
M	3.40.50.10280	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal domain	CATH (utative)
M	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (utative)
N	3.40.50.10280	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal domain	CATH (utative)
N	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (utative)
P	3.40.50.10280	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal domain	CATH (utative)
P	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (utative)
Q	3.40.50.10280	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal domain	CATH (utative)
Q	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (utative)
R	3.40.50.10280	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal domain	CATH (utative)
R	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (utative)
T	3.40.50.10280	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal domain	CATH (utative)
T	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (utative)
U	3.40.50.10280	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal domain	CATH (utative)
U	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (utative)
V	3.40.50.10280	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal domain	CATH (utative)
V	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (utative)
W	3.40.50.10280	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal domain	CATH (utative)
W	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (utative)
X	3.40.50.10280	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal domain	CATH (utative)
X	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (utative)
G	3.40.50.10280	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal domain	CATH (utative)
G	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (utative)
J	3.40.50.10280	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal domain	CATH (utative)
J	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (utative)
O	3.40.50.10280	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal domain	CATH (utative)
O	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (utative)
S	3.40.50.10280	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal domain	CATH (utative)
S	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	PF09176	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal (Mpt_N)	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal	Members of this family adopt a alpha-beta structure, with a core comprising three alpha/beta/alpha layers, in which each sheet contains four strands. They are predominantly found in prokaryotic methylene-tetrahydromethanopterin dehydrogenase, which c ...	Members of this family adopt a alpha-beta structure, with a core comprising three alpha/beta/alpha layers, in which each sheet contains four strands. They are predominantly found in prokaryotic methylene-tetrahydromethanopterin dehydrogenase, which catalyses the dehydrogenation of methylene-tetrahydromethanopterin and the reversible dehydrogenation of methylene-H(4)F [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	Bifunctional NADP-dependent methylenetetrahydromethanopterin dehydrogenase/methylenetetrahydrofolate dehydrogenase	methylenetetrahydrofolate dehydrogenase (NADP+) activity oxidoreductase activity oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on the CH-NH group of donors methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity catalytic activity	cellular response to stimulus cellular detoxification catabolic process response to stimulus formaldehyde catabolic process detoxification response to oxygen-containing compound cellular response to oxygen-containing compound aldehyde metabolic process response to toxic substance cellular detoxification of aldehyde cellular response to chemical stimulus cellular response to aldehyde response to chemical cellular response to stimulus cellular detoxification catabolic process response to stimulus formaldehyde catabolic process detoxification response to oxygen-containing compound cellular response to oxygen-containing compound aldehyde metabolic process response to toxic substance cellular detoxification of aldehyde cellular response to chemical stimulus cellular response to aldehyde response to chemical metabolic process cellular process small molecule metabolic process formaldehyde metabolic process aldehyde catabolic process small molecule catabolic process cellular response to toxic substance one-carbon metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	IPR037089	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	IPR046346	Aminoacid dehydrogenase-like, N-terminal domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	IPR035015	Methylene tetrahydromethanopterin dehydrogenase, NADP-binding domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	IPR015259	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal	Domain