6WK9

Crystal structure of Gdx-Clo from Small Multidrug Resistance family of transporters in complex with octylguanidinium

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C	d6wk9c_	All beta proteins	Immunoglobulin-like beta-sandwich	Fibronectin type III	automated matches	automated matches	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d6wk9d_	All beta proteins	Immunoglobulin-like beta-sandwich	Fibronectin type III	automated matches	automated matches	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G	d6wk9g_	All beta proteins	Immunoglobulin-like beta-sandwich	Fibronectin type III	automated matches	automated matches	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H	d6wk9h_	All beta proteins	Immunoglobulin-like beta-sandwich	Fibronectin type III	automated matches	automated matches	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	Multi_Drug_Res	e6wk9B1	A: alpha bundles	X: Drug/Metabolite transporter (From Topology)	H: Drug/Metabolite transporter (From Topology)	T: Drug/Metabolite transporter	F: Multi_Drug_Res	ECOD (1.6)
B [auth A]	Multi_Drug_Res	e6wk9A1	A: alpha bundles	X: Drug/Metabolite transporter (From Topology)	H: Drug/Metabolite transporter (From Topology)	T: Drug/Metabolite transporter	F: Multi_Drug_Res	ECOD (1.6)
E [auth F]	Multi_Drug_Res	e6wk9F1	A: alpha bundles	X: Drug/Metabolite transporter (From Topology)	H: Drug/Metabolite transporter (From Topology)	T: Drug/Metabolite transporter	F: Multi_Drug_Res	ECOD (1.6)
F [auth E]	Multi_Drug_Res	e6wk9E1	A: alpha bundles	X: Drug/Metabolite transporter (From Topology)	H: Drug/Metabolite transporter (From Topology)	T: Drug/Metabolite transporter	F: Multi_Drug_Res	ECOD (1.6)
C	fn3	e6wk9C1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: fn3	ECOD (1.6)
D	fn3	e6wk9D1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: fn3	ECOD (1.6)
G	fn3	e6wk9G1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: fn3	ECOD (1.6)
H	fn3	e6wk9H1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: fn3	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth A], E [auth F], F [auth E]	PF00893	Small Multidrug Resistance protein (Multi_Drug_Res)	Small Multidrug Resistance protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth A], E [auth F], F [auth E]	Multidrug resistance protein, SMR family	transporter activity transmembrane transporter activity	-	cell periphery cellular anatomical structure plasma membrane membrane
C, D, G, H	L10 monobody	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth A], E [auth F], F [auth E]	IPR000390	Small drug/metabolite transporter protein family	Family
A [auth B], B [auth A], E [auth F], F [auth E]	IPR045324	Small multidrug resistance protein	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A [auth B], B [auth A], E [auth F], F [auth E]	OPM	Transmembrane	Alpha-helical polytopic	Drug/Metabolite Transporter (DMT)	Small multidrug resistance family

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A [auth B], B [auth A], E [auth F], F [auth E]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A [auth B], B [auth A], E [auth F], F [auth E]	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A [auth B], B [auth A], E [auth F], F [auth E]	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Multi-Drug Efflux Transporters	Gdx-Clo multi-drug efflux transporter

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.