Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad6xa9a2 Alpha and beta proteins (a+b) Cysteine proteinases Cysteine proteinases Papain-like viral protease catalytic domain automated matches 2019-nCoV (Severe acute respiratory syndrome coronavirus 2 ) [TaxId: 2697049 ], SCOPe (2.08)
Ad6xa9a1 Alpha and beta proteins (a+b) beta-Grasp (ubiquitin-like) Ubiquitin-like automated matches automated matches 2019-nCoV (Severe acute respiratory syndrome coronavirus 2 ) [TaxId: 2697049 ], SCOPe (2.08)
Cd6xa9c2 Alpha and beta proteins (a+b) Cysteine proteinases Cysteine proteinases Papain-like viral protease catalytic domain automated matches 2019-nCoV (Severe acute respiratory syndrome coronavirus 2 ) [TaxId: 2697049 ], SCOPe (2.08)
Cd6xa9c1 Alpha and beta proteins (a+b) beta-Grasp (ubiquitin-like) Ubiquitin-like automated matches automated matches 2019-nCoV (Severe acute respiratory syndrome coronavirus 2 ) [TaxId: 2697049 ], SCOPe (2.08)
Ed6xa9e2 Alpha and beta proteins (a+b) Cysteine proteinases Cysteine proteinases Papain-like viral protease catalytic domain automated matches 2019-nCoV (Severe acute respiratory syndrome coronavirus 2 ) [TaxId: 2697049 ], SCOPe (2.08)
Ed6xa9e1 Alpha and beta proteins (a+b) beta-Grasp (ubiquitin-like) Ubiquitin-like automated matches automated matches 2019-nCoV (Severe acute respiratory syndrome coronavirus 2 ) [TaxId: 2697049 ], SCOPe (2.08)
Bd6xa9b_ Alpha and beta proteins (a+b) beta-Grasp (ubiquitin-like) Ubiquitin-like automated matches automated matches Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Dd6xa9d_ Alpha and beta proteins (a+b) beta-Grasp (ubiquitin-like) Ubiquitin-like automated matches automated matches Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Fd6xa9f_ Alpha and beta proteins (a+b) beta-Grasp (ubiquitin-like) Ubiquitin-like automated matches automated matches Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyCysteine proteinases 8092567 3001808 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyUbiquitin-like 8092569 3000157 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyCysteine proteinases 8092567 3001808 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyPLpro Zn-binding domain-like 8092568 3002538 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyPLpro Zn-binding domain-like 8092568 3002538 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyCysteine proteinases 8092567 3001808 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyCysteine proteinases 8092567 3001808 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyUbiquitin-like 8092569 3000157 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyUbiquitin-like 8092569 3000157 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyCysteine proteinases 8092567 3001808 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyPLpro Zn-binding domain-like 8092568 3002538 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyCysteine proteinases 8092567 3001808 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyUbiquitin-like 8035116 3000157 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyUbiquitin-like 8035116 3000157 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyUbiquitin-like 8035116 3000157 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AViral_protease_Ne6xa9A2 A: a+b two layersX: beta-GraspH: Ubiquitin-relatedT: Ubiquitin-likeF: Viral_protease_NECOD (1.6)
AViral_protease_Ce6xa9A1 A: a+b complex topologyX: Cysteine proteinases-likeH: Cysteine proteinases (From Topology)T: Cysteine proteinasesF: Viral_protease_CECOD (1.6)
CViral_protease_Ne6xa9C2 A: a+b two layersX: beta-GraspH: Ubiquitin-relatedT: Ubiquitin-likeF: Viral_protease_NECOD (1.6)
CViral_protease_Ce6xa9C1 A: a+b complex topologyX: Cysteine proteinases-likeH: Cysteine proteinases (From Topology)T: Cysteine proteinasesF: Viral_protease_CECOD (1.6)
EViral_protease_Ne6xa9E1 A: a+b two layersX: beta-GraspH: Ubiquitin-relatedT: Ubiquitin-likeF: Viral_protease_NECOD (1.6)
EViral_protease_Ce6xa9E2 A: a+b complex topologyX: Cysteine proteinases-likeH: Cysteine proteinases (From Topology)T: Cysteine proteinasesF: Viral_protease_CECOD (1.6)
Bubiquitin_2e6xa9B1 A: a+b two layersX: beta-GraspH: Ubiquitin-relatedT: Ubiquitin-likeF: ubiquitin_2ECOD (1.6)
Dubiquitin_2e6xa9D1 A: a+b two layersX: beta-GraspH: Ubiquitin-relatedT: Ubiquitin-likeF: ubiquitin_2ECOD (1.6)
Fubiquitin_2e6xa9F1 A: a+b two layersX: beta-GraspH: Ubiquitin-relatedT: Ubiquitin-likeF: ubiquitin_2ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
B, D, F
PF00240Ubiquitin family (ubiquitin)Ubiquitin familyThis family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) (see Swiss:Q02724), Nedd8 (see Swiss:P29595), Elongin B (see Swiss:Q15370), Rub1 (see Swiss:Q9SHE7), and Parkin (see Swiss:O60260). A number of them are thought to carry ...This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) (see Swiss:Q02724), Nedd8 (see Swiss:P29595), Elongin B (see Swiss:Q15370), Rub1 (see Swiss:Q9SHE7), and Parkin (see Swiss:O60260). A number of them are thought to carry a distinctive five-residue motif termed the proteasome-interacting motif (PIM), which may have a biologically significant role in protein delivery to proteasomes and recruitment of proteasomes to transcription sites [5].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, C, E
Non-structural protein 3
B, D, F
ISG15 CTD-propargylamide

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, C, E
IPR022733DPUP/SUD, C-terminal, betacoronavirusDomain
A, C, E
IPR042515Non-structural protein NSP15, N-terminal domain superfamily, coronavirusHomologous Superfamily
A, C, E
IPR043174Non-structural protein NSP15, middle domain superfamilyHomologous Superfamily
A, C, E
IPR044315Nonstructural protein 14, betacoronavirusDomain
A, C, E
IPR038123Non-structural protein NSP4, C-terminal superfamily, coronavirusHomologous Superfamily
A, C, E
IPR042570Non-structural protein NSP3, nucleic acid-binding domain superfamily, betacoronavirusHomologous Superfamily
A, C, E
IPR043178Papain-like protease, thumb domain superfamily, coronavirusHomologous Superfamily
A, C, E
IPR046441RNA-dependent RNA polymerase, coronavirusDomain
A, C, E
IPR044863Nidovirus RdRp-associated nucleotidyl transferase (NiRAN) domainDomain
A, C, E
IPR044343Nonstructural protein 13, 1B domain, coronavirusDomain
A, C, E
IPR038166Polyprotein cleavage domain PL2pro superfamily, betacoronavirusHomologous Superfamily
A, C, E
IPR037227Endoribonuclease EndoU-likeHomologous Superfamily
A, C, E
IPR027352Nonstructural protein 13, zinc-binding domain, coronavirus-likeDomain
A, C, E
IPR009003Peptidase S1, PA clanHomologous Superfamily
A, C, E
IPR013016Peptidase C16, coronavirusDomain
A, C, E
IPR009466Non-structural protein 14, coronavirusDomain
A, C, E
IPR044357NSP3, first ubiquitin-like (Ubl) domain, coronavirusDomain
A, C, E
IPR046436Nidovirus 3'-5' exoribonuclease domainDomain
A, C, E
IPR047570NSP12, interface domain, coronavirusDomain
A, C, E
IPR018995RNA synthesis protein NSP10, coronavirusDomain
A, C, E
IPR043615Nonstructural protein 2, N-terminal domain, coronavirusDomain
A, C, E
IPR050534Coronaviruses polyprotein 1abFamily
A, C, E
IPR043177Papain-like protease, N-terminal domain superfamily, coronavirusHomologous Superfamily
A, C, E
IPR043606Coronavirus replicase NSP15, N-terminal oligomerizationDomain
A, C, E
IPR044330Nonstructural protein 15, N-terminal domain, alpha/beta-coronavirusDomain
A, C, E
IPR041679DNA2/NAM7 helicase-like, C-terminalDomain
A, C, E
IPR024375Non-structural protein NSP3, SUD-M domain, betacoronavirusDomain
A, C, E
IPR014828Non-structural protein NSP7, coronavirusDomain
A, C, E
IPR043503Papain-like viral protease, palm and finger domains, coronavirusHomologous Superfamily
A, C, E
IPR014829Non-structural protein NSP8, coronavirusDomain
A, C, E
IPR036499Non-structural protein NSP9 superfamily, coronavirusHomologous Superfamily
A, C, E
IPR029063S-adenosyl-L-methionine-dependent methyltransferase superfamilyHomologous Superfamily
A, C, E
IPR044389Non-structural protein 2, SARS-CoV-likeDomain
A, C, E
IPR043502DNA/RNA polymerase superfamilyHomologous Superfamily
A, C, E
IPR008740Peptidase C30, coronavirusDomain
A, C, E
IPR036333RNA synthesis protein NSP10 superfamily, coronavirusHomologous Superfamily
A, C, E
IPR047573Non-structural protein 2, middle domain, coronavirusDomain
A, C, E
IPR049894Coronavirus NSP3, 3Ecto domainDomain
A, C, E
IPR043472Macro domain-likeHomologous Superfamily
A, C, E
IPR043609NendoU domain, nidovirusDomain
A, C, E
IPR032592Non-structural protein NSP3, nucleic acid-binding domain, betacoronavirusDomain
A, C, E
IPR043613Non-structural protein 2, C-terminal domain, coronavirusDomain
A, C, E
IPR038083Non-structural protein NSP3A domain-like superfamilyHomologous Superfamily
A, C, E
IPR043504Peptidase S1, PA clan, chymotrypsin-like foldHomologous Superfamily
A, C, E
IPR044351RNA-dependent RNA polymerase, SARS-CoV-likeDomain
A, C, E
IPR024358Non-structural protein NSP3, N-terminal, betacoronavirusDomain
A, C, E
IPR048673Nonstructural protein 13, stalk domain, coronavirusDomain
A, C, E
IPR046435NSP14, guanine-N7-methyltransferase domain, coronavirusDomain
A, C, E
IPR009469RNA-dependent RNA polymerase, N-terminal, coronavirusDomain
A, C, E
IPR043611Coronavirus replicase NSP3, C-terminalDomain
A, C, E
IPR044864Non-structural protein NSP3, SUD-N (Mac2) domain, betacoronavirusDomain
A, C, E
IPR047566Coronavirus replicase NSP3, Y domainDomain
A, C, E
IPR048672Nonstructural protein 13, zinc-binding domain, coronavirusDomain
A, C, E
IPR043612Non-structural protein NSP4, N-terminal, coronavirusDomain
A, C, E
IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily
A, C, E
IPR043608Nonstructural protein 15, middle domain, coronavirusDomain
A, C, E
IPR044353NSP3, second ubiquitin-like (Ubl) domain, coronavirusDomain
A, C, E
IPR037204Non-structural protein NSP7 superfamily, coronavirusHomologous Superfamily
A, C, E
IPR046443NSP1, globular domain, alpha/betacoronavirusDomain
A, C, E
IPR043610Non-structural protein 6, coronavirusDomain
A, C, E
IPR027351(+) RNA virus helicase core domainDomain
A, C, E
IPR044322Nonstructural protein 15, middle domain, alpha/betacoronavirusDomain
A, C, E
IPR009461Non-structural protein NSP16, coronavirus-likeDomain
A, C, E
IPR043477Peptidase C30, domain 3, coronavirusHomologous Superfamily
A, C, E
IPR043478Non-structural protein NSP3, SUD-N (Mac2) domain superfamily, betacoronavirusHomologous Superfamily
A, C, E
IPR038400Non-structural protein NSP3, SUD-M domain superfamily, betacoronavirusHomologous Superfamily
A, C, E
IPR046442NSP1, C-terminal domain, betacoronavirusDomain
A, C, E
IPR001205RNA-directed RNA polymerase, C-terminal domainDomain
A, C, E
IPR044401NSP15, NendoU domain, coronavirusDomain
A, C, E
IPR014822Non-structural protein NSP9, coronavirusDomain
A, C, E
IPR038030NSP1 globular domain superfamily, betacoronavirusHomologous Superfamily
A, C, E
IPR021590NSP1, globular domain, betacoronavirusDomain
A, C, E
IPR044367Non-structural protein 6, betacoronavirusDomain
A, C, E
IPR037230Non-structural protein NSP8 superfamily, coronavirusHomologous Superfamily
A, C, E
IPR046440Arterivirus Nsp11 N-terminal/Coronavirus NSP15 middle domainDomain
A, C, E
IPR032505Non-structural protein NSP4, C-terminal, coronavirusDomain
A, C, E
IPR046438Nidovirus 2-O-methyltransferaseDomain
A, C, E
IPR002589Macro domainDomain
A, C, E
IPR047567Non-structural protein NSP3, group 2-specific marker domain, betacoronavirusDomain
A, C, E
IPR044371Non-structural protein 3, X-domain-likeDomain
A, C, E
IPR007094RNA-directed RNA polymerase, catalytic domainDomain
B, D, F
IPR000626Ubiquitin-like domainDomain
B, D, F
IPR015496UbiquilinFamily
B, D, F
IPR019956Ubiquitin domainDomain
B, D, F
IPR029071Ubiquitin-like domain superfamilyHomologous Superfamily