6XSY

The external aldimine crystal structure of Salmonella typhimurium Tryptophan Synthase mutant beta-S377A with inhibitor 2-({[4-(trifluoromethoxy)phenyl]sulfonyl}amino)ethyl dihydrogen phosphate (F9F) at the alpha-site, Cesium ion at the metal coordination site, and (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-serine (KOU) at the beta-site


Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyRibulose-phoshate binding barrel 8032560 3000216 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyTryptophan synthase beta subunit-like PLP-dependent enzymes 8032976 3001427 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ATrp_syntAe6xsyA1 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: Trp_syntAECOD (1.6)
BPALPe6xsyB1 A: a/b three-layered sandwichesX: Rossmann-likeH: Tryptophan synthase beta subunit-like PLP-dependent enzymes (From Topology)T: Tryptophan synthase beta subunit-like PLP-dependent enzymesF: PALPECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00290Tryptophan synthase alpha chain (Trp_syntA)Tryptophan synthase alpha chain- Domain
PF00291Pyridoxal-phosphate dependent enzyme (PALP)Pyridoxal-phosphate dependent enzyme- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Tryptophan synthase alpha chain
Tryptophan synthase beta chain