6YG4

Crystal structure of MKK7 (MAP2K7) in complex with K00007

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6yg4a_	Alpha and beta proteins (a+b)	Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Protein kinase-like (PK-like)	8067263	3000066	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Pkinase_Tyr	e6yg4A1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00069	Protein kinase domain (Pkinase)	Protein kinase domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Dual specificity mitogen-activated protein kinase kinase 7	MAP kinase kinase activity protein serine/threonine/tyrosine kinase activity catalytic activity, acting on a protein JUN kinase kinase activity kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein serine kinase activity protein phosphatase binding phosphatase binding protein binding MAP kinase kinase activity protein serine/threonine/tyrosine kinase activity catalytic activity, acting on a protein JUN kinase kinase activity kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein serine kinase activity protein phosphatase binding phosphatase binding protein binding binding enzyme binding protein tyrosine kinase activity cation binding magnesium ion binding ion binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding protein serine/threonine kinase activity MAP kinase activity kinase binding protein kinase binding molecular function activator activity molecular function regulator activity	neuron apoptotic process regulation of biological process regulation of cellular process regulation of apoptotic process biological regulation regulation of programmed cell death regulation of motor neuron apoptotic process motor neuron apoptotic process cell death cellular process apoptotic process programmed cell death regulation of neuron apoptotic process cellular response to stimulus neuron apoptotic process regulation of biological process regulation of cellular process regulation of apoptotic process biological regulation regulation of programmed cell death regulation of motor neuron apoptotic process motor neuron apoptotic process cell death cellular process apoptotic process programmed cell death regulation of neuron apoptotic process cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of cellular process regulation of signaling positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade regulation of cell communication ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of signaling stress-activated MAPK cascade stress-activated protein kinase signaling cascade cellular response to stress response to stress biological process involved in interspecies interaction between organisms response to lipid response to other organism cellular response to lipopolysaccharide response to oxygen-containing compound response to external stimulus cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound response to biotic stimulus cellular response to biotic stimulus cellular response to chemical stimulus response to chemical response to bacterium cellular response to lipid response to external biotic stimulus response to molecule of bacterial origin cellular senescence metabolic process positive regulation of JNK cascade JNK cascade regulation of JNK cascade response to light stimulus response to radiation response to abiotic stimulus response to UV positive regulation of organelle organization telomere organization regulation of DNA biosynthetic process positive regulation of macromolecule biosynthetic process RNA-templated DNA biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process telomere maintenance via telomere lengthening positive regulation of metabolic process positive regulation of telomere maintenance via telomere lengthening positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of telomere maintenance positive regulation of nucleobase-containing compound metabolic process primary metabolic process DNA metabolic process regulation of chromosome organization regulation of telomere maintenance via telomere lengthening regulation of organelle organization positive regulation of chromosome organization telomere maintenance biosynthetic process positive regulation of DNA metabolic process positive regulation of telomere maintenance via telomerase regulation of macromolecule biosynthetic process macromolecule metabolic process DNA biosynthetic process regulation of metabolic process regulation of DNA metabolic process regulation of telomere maintenance regulation of cellular component organization positive regulation of cellular component organization cellular component organization nucleic acid biosynthetic process positive regulation of biosynthetic process cellular component organization or biogenesis regulation of biosynthetic process telomere maintenance via telomerase chromosome organization positive regulation of DNA biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process regulation of telomere maintenance via telomerase organelle organization response to wounding immune response-regulating cell surface receptor signaling pathway cell surface receptor signaling pathway immune response Fc receptor signaling pathway immune response-regulating signaling pathway immune system process Fc-epsilon receptor signaling pathway regulation of immune response regulation of immune system process positive regulation of DNA-templated transcription RNA metabolic process RNA biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of RNA biosynthetic process gene expression positive regulation of RNA metabolic process regulation of gene expression positive regulation of RNA biosynthetic process regulation of DNA-templated transcription positive regulation of phosphorylation regulation of catalytic activity regulation of transferase activity positive regulation of phosphate metabolic process regulation of MAP kinase activity positive regulation of protein serine/threonine kinase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process phosphorus metabolic process protein modification process positive regulation of protein phosphorylation positive regulation of MAP kinase activity protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process positive regulation of JUN kinase activity regulation of molecular function positive regulation of kinase activity regulation of kinase activity regulation of protein serine/threonine kinase activity macromolecule modification regulation of phosphorus metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of molecular function positive regulation of protein modification process protein metabolic process positive regulation of protein kinase activity positive regulation of transferase activity positive regulation of catalytic activity regulation of protein kinase activity regulation of JUN kinase activity regulation of phosphorylation positive regulation of telomere capping telomere capping regulation of telomere capping response to heat response to temperature stimulus response to peptide cellular response to interleukin-1 response to cytokine cellular response to cytokine stimulus response to interleukin-1 response to osmotic stress response to tumor necrosis factor	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR052468	Dual specificity MAP kinase kinase	Family
A	IPR000719	Protein kinase domain	Domain
A	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A	IPR008271	Serine/threonine-protein kinase, active site	Active Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O14733	congestive heart failure Mammary Neoplasms, Experimental breast carcinoma pancreatic ductal adenocarcinoma atypical teratoid rhabdoid tumor glioblastoma lung benign neoplasm osteosarcoma pancreatic intraductal papillary-mucinous carcinoma schizophrenia breast cancer colorectal adenocarcinoma Emery-Dreifuss muscular dystrophy large cell medulloblastoma ovarian cancer congestive heart failure Mammary Neoplasms, Experimental breast carcinoma pancreatic ductal adenocarcinoma atypical teratoid rhabdoid tumor glioblastoma lung benign neoplasm osteosarcoma pancreatic intraductal papillary-mucinous carcinoma schizophrenia breast cancer colorectal adenocarcinoma Emery-Dreifuss muscular dystrophy large cell medulloblastoma ovarian cancer precancerous condition heart failure malignant glioma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A	CSD	Parent Component: CYS RESID: AA0262 PSI-MOD : L-cysteine sulfinic acid MOD:00267
A	CSO	Parent Component: CYS RESID: AA0262 , AA0205 PSI-MOD : L-cysteine sulfinic acid MOD:00267 , L-cysteine sulfenic acid MOD:00210

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.