6ZEE

Structure of PP1(7-300) bound to Phactr1 (507-580) at pH8.4

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth P]	d6zeep1	Alpha and beta proteins (a+b)	Metallo-dependent phosphatases	Metallo-dependent phosphatases	Protein serine/threonine phosphatase	Protein phosphatase-1 (PP-1)	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A [auth P]	d6zeep2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B [auth Q]	d6zeeq1	Alpha and beta proteins (a+b)	Metallo-dependent phosphatases	Metallo-dependent phosphatases	Protein serine/threonine phosphatase	Protein phosphatase-1 (PP-1)	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B [auth Q]	d6zeeq2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth B]	d6zeeb1	Alpha and beta proteins (a+b)	Metallo-dependent phosphatases	Metallo-dependent phosphatases	Protein serine/threonine phosphatase	Protein phosphatase-1 (PP-1)	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth B]	d6zeeb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D [auth A]	d6zeea1	Alpha and beta proteins (a+b)	Metallo-dependent phosphatases	Metallo-dependent phosphatases	Protein serine/threonine phosphatase	Protein phosphatase-1 (PP-1)	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D [auth A]	d6zeea2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E [auth I]	d6zeei1	Alpha and beta proteins (a+b)	Metallo-dependent phosphatases	Metallo-dependent phosphatases	Protein serine/threonine phosphatase	Protein phosphatase-1 (PP-1)	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E [auth I]	d6zeei2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F [auth K]	d6zeek1	Alpha and beta proteins (a+b)	Metallo-dependent phosphatases	Metallo-dependent phosphatases	Protein serine/threonine phosphatase	Protein phosphatase-1 (PP-1)	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F [auth K]	d6zeek2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth P]	SCOP2B Superfamily	Metallo-dependent phosphatases	8080445	3001067	SCOP2B (2022-06-29)
B [auth Q]	SCOP2B Superfamily	Metallo-dependent phosphatases	8080445	3001067	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	Metallo-dependent phosphatases	8080445	3001067	SCOP2B (2022-06-29)
D [auth A]	SCOP2B Superfamily	Metallo-dependent phosphatases	8080445	3001067	SCOP2B (2022-06-29)
E [auth I]	SCOP2B Superfamily	Metallo-dependent phosphatases	8080445	3001067	SCOP2B (2022-06-29)
F [auth K]	SCOP2B Superfamily	Metallo-dependent phosphatases	8080445	3001067	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth P]	Metallophos_2_1	e6zeeP1	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: Metallo-dependent phosphatases (From Topology)	T: Metallo-dependent phosphatases	F: Metallophos_2_1	ECOD (1.6)
B [auth Q]	Metallophos_2_1	e6zeeQ1	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: Metallo-dependent phosphatases (From Topology)	T: Metallo-dependent phosphatases	F: Metallophos_2_1	ECOD (1.6)
C [auth B]	Metallophos_2_1	e6zeeB1	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: Metallo-dependent phosphatases (From Topology)	T: Metallo-dependent phosphatases	F: Metallophos_2_1	ECOD (1.6)
D [auth A]	Metallophos_2_1	e6zeeA1	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: Metallo-dependent phosphatases (From Topology)	T: Metallo-dependent phosphatases	F: Metallophos_2_1	ECOD (1.6)
E [auth I]	Metallophos_2_1	e6zeeI1	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: Metallo-dependent phosphatases (From Topology)	T: Metallo-dependent phosphatases	F: Metallophos_2_1	ECOD (1.6)
F [auth K]	Metallophos_2_1	e6zeeK1	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: Metallo-dependent phosphatases (From Topology)	T: Metallo-dependent phosphatases	F: Metallophos_2_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth P], B [auth Q], C [auth B], D [auth A], E [auth I], A [auth P], B [auth Q], C [auth B], D [auth A], E [auth I], F [auth K]	PF00149	Calcineurin-like phosphoesterase (Metallophos)	Calcineurin-like phosphoesterase	This family includes a diverse range of phosphoesterases [1], including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD Swiss:P13457 or ...	This family includes a diverse range of phosphoesterases [1], including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD Swiss:P13457 or yeast MRE11 Swiss:P32829. The most conserved regions in this superfamily centre around the metal chelating residues.	Domain
A [auth P], B [auth Q], C [auth B], D [auth A], E [auth I], A [auth P], B [auth Q], C [auth B], D [auth A], E [auth I], F [auth K]	PF16891	Serine-threonine protein phosphatase N-terminal domain (STPPase_N)	Serine-threonine protein phosphatase N-terminal domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth P], B [auth Q], C [auth B], D [auth A], E [auth I], A [auth P], B [auth Q], C [auth B], D [auth A], E [auth I], F [auth K]	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity cation binding transition metal ion binding ion binding binding metal ion binding small molecule binding phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity cation binding transition metal ion binding ion binding binding metal ion binding small molecule binding cell adhesion molecule binding cadherin binding involved in cell-cell adhesion cadherin binding protein binding cell adhesion mediator activity cell-cell adhesion mediator activity ribonucleoprotein complex binding protein-containing complex binding myosin phosphatase activity protein phosphatase binding phosphatase binding protein phosphatase 1 binding enzyme binding iron ion binding	cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process cell surface receptor signaling pathway response to stimulus regulation of Wnt signaling pathway signaling regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway biological regulation regulation of signal transduction cell communication regulation of response to stimulus cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process cell surface receptor signaling pathway response to stimulus regulation of Wnt signaling pathway signaling regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway biological regulation regulation of signal transduction cell communication regulation of response to stimulus regulation of cell communication cellular process signal transduction Wnt signaling pathway telomere maintenance in response to DNA damage telomere organization chromosome organization primary metabolic process DNA metabolic process nucleic acid metabolic process telomere maintenance cellular component organization nucleobase-containing compound metabolic process organelle organization cellular response to stress DNA damage response response to stress metabolic process cellular component organization or biogenesis macromolecule metabolic process developmental process multicellular organismal process epithelium development tube development branching morphogenesis of an epithelial tube morphogenesis of an epithelium tissue development tissue morphogenesis anatomical structure morphogenesis multicellular organism development tube morphogenesis morphogenesis of a branching structure anatomical structure development epithelial tube morphogenesis morphogenesis of a branching epithelium regulation of glycogen biosynthetic process glucan biosynthetic process energy derivation by oxidation of organic compounds cellular biosynthetic process regulation of glucan biosynthetic process regulation of generation of precursor metabolites and energy regulation of polysaccharide metabolic process regulation of primary metabolic process polysaccharide metabolic process glucan metabolic process regulation of carbohydrate metabolic process regulation of biosynthetic process carbohydrate metabolic process polysaccharide biosynthetic process carbohydrate biosynthetic process cellular metabolic process glycogen metabolic process regulation of cellular metabolic process generation of precursor metabolites and energy regulation of macromolecule metabolic process glycogen biosynthetic process macromolecule biosynthetic process regulation of cellular biosynthetic process biosynthetic process regulation of polysaccharide biosynthetic process energy reserve metabolic process regulation of macromolecule biosynthetic process regulation of carbohydrate biosynthetic process regulation of glycogen metabolic process regulation of metabolic process rhythmic process circadian rhythm regulation of circadian rhythm cell division positive regulation of cell communication positive regulation of signal transduction signal transduction in absence of ligand positive regulation of biological process regulation of programmed cell death positive regulation of extrinsic apoptotic signaling pathway in absence of ligand extrinsic apoptotic signaling pathway positive regulation of apoptotic signaling pathway positive regulation of response to stimulus extrinsic apoptotic signaling pathway in absence of ligand positive regulation of cellular process positive regulation of programmed cell death regulation of apoptotic process positive regulation of extrinsic apoptotic signaling pathway cell death positive regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway regulation of extrinsic apoptotic signaling pathway in absence of ligand apoptotic process programmed cell death regulation of apoptotic signaling pathway positive regulation of signaling protein dephosphorylation dephosphorylation macromolecule modification phosphate-containing compound metabolic process protein metabolic process protein modification process phosphorus metabolic process animal organ development respiratory tube development lung development respiratory system development system development catabolic process carbohydrate catabolic process macromolecule catabolic process regulation of glycogen catabolic process glycogen catabolic process regulation of carbohydrate catabolic process glucan catabolic process regulation of catabolic process polysaccharide catabolic process circadian regulation of gene expression gene expression regulation of gene expression response to light stimulus entrainment of circadian clock response to external stimulus photoperiodism response to radiation response to abiotic stimulus entrainment of circadian clock by photoperiod response to metal ion response to chemical response to lead ion post-transcriptional regulation of gene expression translational initiation regulation of translational initiation regulation of protein metabolic process translation regulation of translation	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle somatodendritic compartment cell body perikaryon neuronal cell body phosphatase complex protein-containing complex protein phosphatase type 1 complex catalytic complex cytoplasm protein serine/threonine phosphatase complex PTW/PP1 phosphatase complex extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol cell periphery plasma membrane membrane presynapse synapse cell junction nucleoplasm glutamatergic synapse cell-cell junction adherens junction anchoring junction glycogen granule neuron spine neuron projection dendritic spine plasma membrane bounded cell projection cell projection postsynapse dendrite dendritic tree
G [auth W], H [auth X], I [auth D], J [auth C], K [auth U], G [auth W], H [auth X], I [auth D], J [auth C], K [auth U], L [auth V]	Phosphatase and actin regulator	enzyme regulator activity phosphatase inhibitor activity molecular function inhibitor activity phosphatase regulator activity molecular function regulator activity protein phosphatase regulator activity protein phosphatase inhibitor activity enzyme inhibitor activity cytoskeletal protein binding actin binding protein binding binding	multicellular organismal process cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis dendrite development cell differentiation multicellular organismal process cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis dendrite development cell differentiation anatomical structure development cellular component organization or biogenesis system development developmental process plasma membrane bounded cell projection organization dendrite arborization dendrite morphogenesis nervous system development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron projection arborization neuron development cellular process head development forebrain development animal organ development brain development pallium development cerebral cortex development central nervous system development telencephalon development actomyosin structure organization actin cytoskeleton organization actin filament organization cellular component biogenesis organelle organization cellular component assembly actin filament bundle organization contractile actin filament bundle assembly actin filament-based process actin filament bundle assembly stress fiber assembly supramolecular fiber organization cytoskeleton organization cell motility regulation of biological process regulation of cell motility regulation of cellular process neuron migration biological regulation regulation of neuron migration regulation of locomotion regulation of cell migration cell migration locomotion	synapse cell junction cellular anatomical entity intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth P], B [auth Q], C [auth B], D [auth A], E [auth I], A [auth P], B [auth Q], C [auth B], D [auth A], E [auth I], F [auth K]	IPR050341	Serine/threonine-protein phosphatase PP1 catalytic subunit	Family
A [auth P], B [auth Q], C [auth B], D [auth A], E [auth I], A [auth P], B [auth Q], C [auth B], D [auth A], E [auth I], F [auth K]	IPR004843	Calcineurin-like phosphoesterase domain, ApaH type	Domain
A [auth P], B [auth Q], C [auth B], D [auth A], E [auth I], A [auth P], B [auth Q], C [auth B], D [auth A], E [auth I], F [auth K]	IPR031675	Serine-threonine protein phosphatase, N-terminal	Domain
A [auth P], B [auth Q], C [auth B], D [auth A], E [auth I], A [auth P], B [auth Q], C [auth B], D [auth A], E [auth I], F [auth K]	IPR029052	Metallo-dependent phosphatase-like	Homologous Superfamily
A [auth P], B [auth Q], C [auth B], D [auth A], E [auth I], A [auth P], B [auth Q], C [auth B], D [auth A], E [auth I], F [auth K]	IPR006186	Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase	Domain
G [auth W], H [auth X], I [auth D], J [auth C], K [auth U], G [auth W], H [auth X], I [auth D], J [auth C], K [auth U], L [auth V]	IPR004018	RPEL repeat	Repeat

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth P], B [auth Q], C [auth B], D [auth A], E [auth I], A [auth P], B [auth Q], C [auth B], D [auth A], E [auth I], F [auth K]	Pharos: P62136	lung adenocarcinoma osteosarcoma severe acute respiratory syndrome lymphoplasmacytic lymphoma ovarian cancer Middle East respiratory syndrome plasma cell myeloma
G [auth W], H [auth X], I [auth D], J [auth C], K [auth U], G [auth W], H [auth X], I [auth D], J [auth C], K [auth U], L [auth V]	Pharos: Q9C0D0	myocardial infarction coronary artery disease migraine without aura, susceptibility to, 4 medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma arterial disorder Sjogren syndrome atypical teratoid rhabdoid tumor ulcerative colitis gastric carcinoma hepatocellular carcinoma lung adenocarcinoma malignant glioma myocardial infarction coronary artery disease migraine without aura, susceptibility to, 4 medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma arterial disorder Sjogren syndrome atypical teratoid rhabdoid tumor ulcerative colitis gastric carcinoma hepatocellular carcinoma lung adenocarcinoma malignant glioma migraine disorder non-small cell lung carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia primitive neuroectodermal tumor astrocytic tumor subependymal giant cell astrocytoma Cerebrovascular Trauma vascular brain injury epilepsy glioblastoma intellectual disability lung cancer malignant mesothelioma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma Pick disease progressive supranuclear palsy attention deficit hyperactivity disorder, inattentive type tuberculosis gastric cancer heart disease large cell medulloblastoma malignant ependymoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.