6ZFH

Structure of human galactokinase in complex with galactose and 2'-(benzo[d]oxazol-2-ylamino)-7',8'-dihydro-1'H-spiro[cyclopentane-1,4'-quinazolin]-5'(6'H)-one


Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad6zfha1 Alpha and beta proteins (a+b) Ribosomal protein S5 domain 2-like Ribosomal protein S5 domain 2-like GHMP Kinase, N-terminal domain automated matches Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Ad6zfha2 Alpha and beta proteins (a+b) Ferredoxin-like GHMP Kinase, C-terminal domain Galactokinase automated matches Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Bd6zfhb1 Alpha and beta proteins (a+b) Ribosomal protein S5 domain 2-like Ribosomal protein S5 domain 2-like GHMP Kinase, N-terminal domain automated matches Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Bd6zfhb2 Alpha and beta proteins (a+b) Ferredoxin-like GHMP Kinase, C-terminal domain Galactokinase automated matches Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Cd6zfhc1 Alpha and beta proteins (a+b) Ribosomal protein S5 domain 2-like Ribosomal protein S5 domain 2-like GHMP Kinase, N-terminal domain automated matches Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Cd6zfhc2 Alpha and beta proteins (a+b) Ferredoxin-like GHMP Kinase, C-terminal domain Galactokinase automated matches Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Cd6zfhc3 Artifacts Tags Tags Tags N-terminal Tags Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Dd6zfhd1 Alpha and beta proteins (a+b) Ribosomal protein S5 domain 2-like Ribosomal protein S5 domain 2-like GHMP Kinase, N-terminal domain automated matches Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Dd6zfhd2 Alpha and beta proteins (a+b) Ferredoxin-like GHMP Kinase, C-terminal domain Galactokinase automated matches Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Ed6zfhe1 Alpha and beta proteins (a+b) Ribosomal protein S5 domain 2-like Ribosomal protein S5 domain 2-like GHMP Kinase, N-terminal domain automated matches Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Ed6zfhe2 Alpha and beta proteins (a+b) Ferredoxin-like GHMP Kinase, C-terminal domain Galactokinase automated matches Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Fd6zfhf1 Alpha and beta proteins (a+b) Ribosomal protein S5 domain 2-like Ribosomal protein S5 domain 2-like GHMP Kinase, N-terminal domain automated matches Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Fd6zfhf2 Alpha and beta proteins (a+b) Ferredoxin-like GHMP Kinase, C-terminal domain Galactokinase automated matches Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Gd6zfhg1 Alpha and beta proteins (a+b) Ribosomal protein S5 domain 2-like Ribosomal protein S5 domain 2-like GHMP Kinase, N-terminal domain automated matches Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Gd6zfhg2 Alpha and beta proteins (a+b) Ferredoxin-like GHMP Kinase, C-terminal domain Galactokinase automated matches Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Hd6zfhh1 Alpha and beta proteins (a+b) Ribosomal protein S5 domain 2-like Ribosomal protein S5 domain 2-like GHMP Kinase, N-terminal domain automated matches Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Hd6zfhh2 Alpha and beta proteins (a+b) Ferredoxin-like GHMP Kinase, C-terminal domain Galactokinase automated matches Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyGHMP Kinase, C-terminal domain 8043717 3001245 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyRibosomal protein S5 domain 2-like 8043715 3000100 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyRibosomal protein S5 domain 2-like 8043715 3000100 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyGHMP Kinase, C-terminal domain 8043717 3001245 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyRibosomal protein S5 domain 2-like 8043715 3000100 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyGHMP Kinase, C-terminal domain 8043717 3001245 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyGHMP Kinase, C-terminal domain 8043717 3001245 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyRibosomal protein S5 domain 2-like 8043715 3000100 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyGHMP Kinase, C-terminal domain 8043717 3001245 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyRibosomal protein S5 domain 2-like 8043715 3000100 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyGHMP Kinase, C-terminal domain 8043717 3001245 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyRibosomal protein S5 domain 2-like 8043715 3000100 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyRibosomal protein S5 domain 2-like 8043715 3000100 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyGHMP Kinase, C-terminal domain 8043717 3001245 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyGHMP Kinase, C-terminal domain 8043717 3001245 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyRibosomal protein S5 domain 2-like 8043715 3000100 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AGHMP_kinases_Ne6zfhA1 A: a+b two layersX: Ribosomal protein S5 domain 2-like (From Topology)H: Ribosomal protein S5 domain 2-like (From Topology)T: Ribosomal protein S5 domain 2-likeF: GHMP_kinases_NECOD (1.6)
AGHMP_kinases_Ce6zfhA2 A: a+b two layersX: Alpha-beta plaitsH: GHMP Kinase, C-terminal domain (From Topology)T: GHMP Kinase, C-terminal domainF: GHMP_kinases_CECOD (1.6)
BGHMP_kinases_Ne6zfhB2 A: a+b two layersX: Ribosomal protein S5 domain 2-like (From Topology)H: Ribosomal protein S5 domain 2-like (From Topology)T: Ribosomal protein S5 domain 2-likeF: GHMP_kinases_NECOD (1.6)
BGHMP_kinases_Ce6zfhB1 A: a+b two layersX: Alpha-beta plaitsH: GHMP Kinase, C-terminal domain (From Topology)T: GHMP Kinase, C-terminal domainF: GHMP_kinases_CECOD (1.6)
CGHMP_kinases_Ne6zfhC1 A: a+b two layersX: Ribosomal protein S5 domain 2-like (From Topology)H: Ribosomal protein S5 domain 2-like (From Topology)T: Ribosomal protein S5 domain 2-likeF: GHMP_kinases_NECOD (1.6)
CGHMP_kinases_Ce6zfhC2 A: a+b two layersX: Alpha-beta plaitsH: GHMP Kinase, C-terminal domain (From Topology)T: GHMP Kinase, C-terminal domainF: GHMP_kinases_CECOD (1.6)
DGHMP_kinases_Ne6zfhD1 A: a+b two layersX: Ribosomal protein S5 domain 2-like (From Topology)H: Ribosomal protein S5 domain 2-like (From Topology)T: Ribosomal protein S5 domain 2-likeF: GHMP_kinases_NECOD (1.6)
DGHMP_kinases_Ce6zfhD2 A: a+b two layersX: Alpha-beta plaitsH: GHMP Kinase, C-terminal domain (From Topology)T: GHMP Kinase, C-terminal domainF: GHMP_kinases_CECOD (1.6)
EGHMP_kinases_Ne6zfhE2 A: a+b two layersX: Ribosomal protein S5 domain 2-like (From Topology)H: Ribosomal protein S5 domain 2-like (From Topology)T: Ribosomal protein S5 domain 2-likeF: GHMP_kinases_NECOD (1.6)
EGHMP_kinases_Ce6zfhE1 A: a+b two layersX: Alpha-beta plaitsH: GHMP Kinase, C-terminal domain (From Topology)T: GHMP Kinase, C-terminal domainF: GHMP_kinases_CECOD (1.6)
FGHMP_kinases_Ne6zfhF1 A: a+b two layersX: Ribosomal protein S5 domain 2-like (From Topology)H: Ribosomal protein S5 domain 2-like (From Topology)T: Ribosomal protein S5 domain 2-likeF: GHMP_kinases_NECOD (1.6)
FGHMP_kinases_Ce6zfhF2 A: a+b two layersX: Alpha-beta plaitsH: GHMP Kinase, C-terminal domain (From Topology)T: GHMP Kinase, C-terminal domainF: GHMP_kinases_CECOD (1.6)
GGHMP_kinases_Ne6zfhG1 A: a+b two layersX: Ribosomal protein S5 domain 2-like (From Topology)H: Ribosomal protein S5 domain 2-like (From Topology)T: Ribosomal protein S5 domain 2-likeF: GHMP_kinases_NECOD (1.6)
GGHMP_kinases_Ce6zfhG2 A: a+b two layersX: Alpha-beta plaitsH: GHMP Kinase, C-terminal domain (From Topology)T: GHMP Kinase, C-terminal domainF: GHMP_kinases_CECOD (1.6)
HGHMP_kinases_Ne6zfhH2 A: a+b two layersX: Ribosomal protein S5 domain 2-like (From Topology)H: Ribosomal protein S5 domain 2-like (From Topology)T: Ribosomal protein S5 domain 2-likeF: GHMP_kinases_NECOD (1.6)
HGHMP_kinases_Ce6zfhH1 A: a+b two layersX: Alpha-beta plaitsH: GHMP Kinase, C-terminal domain (From Topology)T: GHMP Kinase, C-terminal domainF: GHMP_kinases_CECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF08544GHMP kinases C terminal (GHMP_kinases_C)GHMP kinases C terminal- Family
A, B, C, D, E
PF10509Galactokinase galactose-binding signature (GalKase_gal_bdg)Galactokinase galactose-binding signatureThis is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry [1]. The function of this domain appears to be to bind galactose [2] ...This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry [1]. The function of this domain appears to be to bind galactose [2], and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6 [3]. This domain is associated with the families GHMP_kinases_C, Pfam:PF08544 and GHMP_kinases_N, Pfam:PF00288.
Domain
A, B, C, D, E
PF00288GHMP kinases N terminal domain (GHMP_kinases_N)GHMP kinases N terminal domain- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D, E
Galactokinase

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C, D, E
IPR013750GHMP kinase, C-terminal domainDomain
A, B, C, D, E
IPR006206Mevalonate/galactokinaseFamily
A, B, C, D, E
IPR019539Galactokinase, N-terminal domainDomain
A, B, C, D, E
IPR036554GHMP kinase, C-terminal domain superfamilyHomologous Superfamily
A, B, C, D, E
IPR006204GHMP kinase N-terminal domainDomain
A, B, C, D, E
IPR019741Galactokinase, conserved siteConserved Site
A, B, C, D, E
IPR006203GHMP kinase, ATP-binding, conserved siteConserved Site
A, B, C, D, E
IPR000705GalactokinaseFamily
A, B, C, D, E
IPR020568Ribosomal protein uS5 domain 2-type superfamilyHomologous Superfamily
A, B, C, D, E
IPR014721Small ribosomal subunit protein uS5 domain 2-type fold, subgroupHomologous Superfamily