6ZGX
Structure of human galactokinase 1 bound with 2-(4-chlorophenyl)-N-(pyrimidin-2-yl)acetamide
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
B | SCOP2B Superfamily | Ribosomal protein S5 domain 2-like | 8043715 | 3000100 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | GHMP Kinase, C-terminal domain | 8043717 | 3001245 | SCOP2B (2022-06-29) |
C [auth D] | SCOP2B Superfamily | GHMP Kinase, C-terminal domain | 8043717 | 3001245 | SCOP2B (2022-06-29) |
C [auth D] | SCOP2B Superfamily | Ribosomal protein S5 domain 2-like | 8043715 | 3000100 | SCOP2B (2022-06-29) |
D [auth E] | SCOP2B Superfamily | Ribosomal protein S5 domain 2-like | 8043715 | 3000100 | SCOP2B (2022-06-29) |
D [auth E] | SCOP2B Superfamily | GHMP Kinase, C-terminal domain | 8043717 | 3001245 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Ribosomal protein S5 domain 2-like | 8043715 | 3000100 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | GHMP Kinase, C-terminal domain | 8043717 | 3001245 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | GHMP_kinases_N | e6zgxB2 | A: a+b two layers | X: Ribosomal protein S5 domain 2-like (From Topology) | H: Ribosomal protein S5 domain 2-like (From Topology) | T: Ribosomal protein S5 domain 2-like | F: GHMP_kinases_N | ECOD (1.6) |
B | GHMP_kinases_C | e6zgxB1 | A: a+b two layers | X: Alpha-beta plaits | H: GHMP Kinase, C-terminal domain (From Topology) | T: GHMP Kinase, C-terminal domain | F: GHMP_kinases_C | ECOD (1.6) |
C [auth D] | GHMP_kinases_N | e6zgxD2 | A: a+b two layers | X: Ribosomal protein S5 domain 2-like (From Topology) | H: Ribosomal protein S5 domain 2-like (From Topology) | T: Ribosomal protein S5 domain 2-like | F: GHMP_kinases_N | ECOD (1.6) |
C [auth D] | GHMP_kinases_C | e6zgxD1 | A: a+b two layers | X: Alpha-beta plaits | H: GHMP Kinase, C-terminal domain (From Topology) | T: GHMP Kinase, C-terminal domain | F: GHMP_kinases_C | ECOD (1.6) |
D [auth E] | GHMP_kinases_N | e6zgxE1 | A: a+b two layers | X: Ribosomal protein S5 domain 2-like (From Topology) | H: Ribosomal protein S5 domain 2-like (From Topology) | T: Ribosomal protein S5 domain 2-like | F: GHMP_kinases_N | ECOD (1.6) |
D [auth E] | GHMP_kinases_C | e6zgxE2 | A: a+b two layers | X: Alpha-beta plaits | H: GHMP Kinase, C-terminal domain (From Topology) | T: GHMP Kinase, C-terminal domain | F: GHMP_kinases_C | ECOD (1.6) |
A | GHMP_kinases_N | e6zgxA1 | A: a+b two layers | X: Ribosomal protein S5 domain 2-like (From Topology) | H: Ribosomal protein S5 domain 2-like (From Topology) | T: Ribosomal protein S5 domain 2-like | F: GHMP_kinases_N | ECOD (1.6) |
A | GHMP_kinases_C | e6zgxA2 | A: a+b two layers | X: Alpha-beta plaits | H: GHMP Kinase, C-terminal domain (From Topology) | T: GHMP Kinase, C-terminal domain | F: GHMP_kinases_C | ECOD (1.6) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
A, B, C [auth D], D [auth E] | PF08544 | GHMP kinases C terminal (GHMP_kinases_C) | GHMP kinases C terminal | - | Family |
A, B, C [auth D], D [auth E] | PF10509 | Galactokinase galactose-binding signature (GalKase_gal_bdg) | Galactokinase galactose-binding signature | This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry [1]. The function of this domain appears to be to bind galactose [2] ... | Domain |
A, B, C [auth D], D [auth E] | PF00288 | GHMP kinases N terminal domain (GHMP_kinases_N) | GHMP kinases N terminal domain | - | Family |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
A, B, C [auth D], D [auth E] | IPR013750 | GHMP kinase, C-terminal domain | Domain |
A, B, C [auth D], D [auth E] | IPR006206 | Mevalonate/galactokinase | Family |
A, B, C [auth D], D [auth E] | IPR019539 | Galactokinase, N-terminal domain | Domain |
A, B, C [auth D], D [auth E] | IPR036554 | GHMP kinase, C-terminal domain superfamily | Homologous Superfamily |
A, B, C [auth D], D [auth E] | IPR006204 | GHMP kinase N-terminal domain | Domain |
A, B, C [auth D], D [auth E] | IPR019741 | Galactokinase, conserved site | Conserved Site |
A, B, C [auth D], D [auth E] | IPR006203 | GHMP kinase, ATP-binding, conserved site | Conserved Site |
A, B, C [auth D], D [auth E] | IPR000705 | Galactokinase | Family |
A, B, C [auth D], D [auth E] | IPR020568 | Ribosomal protein uS5 domain 2-type superfamily | Homologous Superfamily |
A, B, C [auth D], D [auth E] | IPR014721 | Small ribosomal subunit protein uS5 domain 2-type fold, subgroup | Homologous Superfamily |
Pharos: Disease Associations Pharos Homepage Annotation
Chains | Drug Target   | Associated Disease |
---|---|---|
A, B, C [auth D], D [auth E] | P51570 | :