Annotations: 6A04

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6a04a1	Alpha and beta proteins (a+b)	STING C-terminal-like	STING, TM173 CTD-like	Tyrosinase cofactor MelC1	automated matches	Pig (Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
A	d6a04a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Pig (Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
B	d6a04b1	Alpha and beta proteins (a+b)	STING C-terminal-like	STING, TM173 CTD-like	Tyrosinase cofactor MelC1	automated matches	Pig (Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
B	d6a04b2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Pig (Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	STING C-terminal domain-like	8094525	3002114	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	STING C-terminal domain-like	8094525	3002114	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	TMEM173	e6a04A1	A: a/b three-layered sandwiches	X: STING C-terminal domain (From Topology)	H: STING C-terminal domain (From Topology)	T: STING C-terminal domain	F: TMEM173	ECOD (1.6)
B	TMEM173	e6a04B1	A: a/b three-layered sandwiches	X: STING C-terminal domain (From Topology)	H: STING C-terminal domain (From Topology)	T: STING C-terminal domain	F: TMEM173	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.12100	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Stimulator of interferon genes protein	CATH (utative)
B	3.40.50.12100	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Stimulator of interferon genes protein	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF15009	Transmembrane protein 173 (TMEM173)	Transmembrane protein 173	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Stimulator of interferon genes protein	guanyl nucleotide binding binding cyclic nucleotide binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding nucleoside phosphate binding ion binding cyclic-di-GMP binding purine nucleotide binding organic cyclic compound binding anion binding heterocyclic compound binding carbohydrate derivative binding guanyl nucleotide binding binding cyclic nucleotide binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding nucleoside phosphate binding ion binding cyclic-di-GMP binding purine nucleotide binding organic cyclic compound binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein-macromolecule adaptor activity molecular adaptor activity signaling adaptor activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity monoatomic ion channel activity proton channel activity monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity cyclic GMP-AMP binding adenyl ribonucleotide binding adenyl nucleotide binding 2',3'-cyclic GMP-AMP binding identical protein binding protein binding protein homodimerization activity protein dimerization activity	regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms response to stimulus regulation of response to external stimulus positive regulation of biological process response to biotic stimulus positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of immune response regulation of response to stress response to stress innate immune response regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms response to stimulus regulation of response to external stimulus positive regulation of biological process response to biotic stimulus positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of immune response regulation of response to stress response to stress innate immune response regulation of immune system process response to external biotic stimulus positive regulation of immune system process regulation of biological process positive regulation of innate immune response defense response immune response response to other organism regulation of innate immune response biological regulation defense response to symbiont response to external stimulus regulation of response to stimulus immune system process defense response to other organism positive regulation of defense response activation of innate immune response regulation of immune response activation of immune response autophagosome assembly catabolic process organelle assembly vacuole organization macroautophagy autophagy autophagosome organization cellular component biogenesis cellular component organization organelle organization cellular component assembly cellular process metabolic process cellular component organization or biogenesis process utilizing autophagic mechanism multicellular organismal process regulation of cellular process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process cytokine production regulation of cytokine production regulation of multicellular organismal process positive regulation of macromolecule metabolic process regulation of interferon-beta production interferon-beta production positive regulation of cellular process regulation of biosynthetic process positive regulation of type I interferon production type I interferon production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process macromolecule metabolic process positive regulation of interferon-beta production positive regulation of cytokine production regulation of metabolic process regulation of type I interferon production cellular response to stimulus pattern recognition receptor signaling pathway cGAS/STING signaling pathway intracellular signal transduction cell communication immune response-activating signaling pathway signal transduction innate immune response-activating signaling pathway cytoplasmic pattern recognition receptor signaling pathway intracellular receptor signaling pathway signaling immune response-regulating signaling pathway positive regulation of autophagy regulation of catabolic process regulation of autophagy positive regulation of catabolic process regulation of macroautophagy positive regulation of macroautophagy defense response to virus response to virus reticulophagy	cell periphery cellular anatomical structure plasma membrane membrane intracellular anatomical structure cytoplasm membrane-bounded organelle organelle subcompartment intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network cell periphery cellular anatomical structure plasma membrane membrane intracellular anatomical structure cytoplasm membrane-bounded organelle organelle subcompartment intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum membrane cytoplasmic vesicle intracellular vesicle vesicle vacuole autophagosome vacuolar membrane autophagosome membrane bounding membrane of organelle Golgi membrane Golgi apparatus endoplasmic reticulum-Golgi intermediate compartment membrane endoplasmic reticulum-Golgi intermediate compartment perinuclear region of cytoplasm mitochondrial membrane mitochondrion organelle outer membrane organelle envelope mitochondrial envelope mitochondrial outer membrane outer membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR029158	Stimulator of interferon genes protein	Family
A, B	IPR047191	Stimulator of interferon genes protein, C-terminal	Domain
A, B	IPR038623	Stimulator of interferon genes protein, C-terminal domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.