6FJC

Human KIBRA C2 domain mutant C771A in complex with phosphatidylinositol 3,4,5-trisphosphate

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	C2_2	e6fjcA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: C2 domain (From Topology)	T: C2 domain	F: C2_2	ECOD (1.6)
B	C2_2	e6fjcB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: C2 domain (From Topology)	T: C2 domain	F: C2_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.150	Mainly Beta	Sandwich	Immunoglobulin-like	C2 domain	CATH (4.3.0)
B	2.60.40.150	Mainly Beta	Sandwich	Immunoglobulin-like	C2 domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00168	C2 domain (C2)	C2 domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Protein KIBRA	protein-macromolecule adaptor activity molecular adaptor activity signaling adaptor activity transcription coactivator activity transcription regulator activity transcription coregulator activity protein binding binding kinase binding enzyme binding	developmental process multicellular organismal process regulation of biological process regulation of growth regulation of developmental growth regulation of developmental process developmental growth negative regulation of developmental process growth negative regulation of biological process biological regulation organ growth negative regulation of organ growth negative regulation of developmental growth negative regulation of growth developmental process multicellular organismal process regulation of biological process regulation of growth regulation of developmental growth regulation of developmental process developmental growth negative regulation of developmental process growth negative regulation of biological process biological regulation organ growth negative regulation of organ growth negative regulation of developmental growth negative regulation of growth regulation of organ growth regulation of multicellular organismal process negative regulation of multicellular organismal process establishment of cell polarity cellular process establishment or maintenance of cell polarity regulation of localization cellular localization regulation of cellular process regulation of transport transport intracellular transport establishment of localization localization regulation of cellular localization establishment of localization in cell regulation of intracellular transport cell migration cell motility cellular response to stimulus hippo signaling regulation of signaling response to stimulus signaling regulation of signal transduction intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication regulation of hippo signaling signal transduction positive regulation of cell communication positive regulation of signal transduction positive regulation of biological process positive regulation of response to stimulus intracellular signaling cassette positive regulation of cellular process positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade MAPK cascade positive regulation of signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of cell communication negative regulation of cellular process negative regulation of response to stimulus negative regulation of hippo signaling negative regulation of signal transduction RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process	ruffle cell leading edge plasma membrane membrane leading edge membrane plasma membrane bounded cell projection cell periphery cell projection cellular anatomical structure ruffle membrane plasma membrane region cell projection membrane intracellular anatomical structure cytoplasm ruffle cell leading edge plasma membrane membrane leading edge membrane plasma membrane bounded cell projection cell periphery cell projection cellular anatomical structure ruffle membrane plasma membrane region cell projection membrane intracellular anatomical structure cytoplasm cytosol protein-containing complex perinuclear region of cytoplasm membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR037771	WWC, C2 domain	Domain
A, B	IPR051105	WWC/KIBRA Hippo Pathway Regulators	Family
A, B	IPR036020	WW domain superfamily	Homologous Superfamily
A, B	IPR000008	C2 domain	Domain
A, B	IPR035892	C2 domain superfamily	Homologous Superfamily
A, B	IPR001202	WW domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q8IX03	malignant mesothelioma primitive neuroectodermal tumor spina bifida attention deficit hyperactivity disorder, inattentive type depressive disorder large cell medulloblastoma malignant glioma medulloblastoma Nonorganic psychosis pancreatic ductal adenocarcinoma psoriasis atypical teratoid rhabdoid tumor glioblastoma malignant colon neoplasm osteosarcoma malignant mesothelioma primitive neuroectodermal tumor spina bifida attention deficit hyperactivity disorder, inattentive type depressive disorder large cell medulloblastoma malignant glioma medulloblastoma Nonorganic psychosis pancreatic ductal adenocarcinoma psoriasis atypical teratoid rhabdoid tumor glioblastoma malignant colon neoplasm osteosarcoma pilocytic astrocytoma breast cancer interstitial cystitis malignant ependymoma malignant pancreatic neoplasm nephrosclerosis ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.