Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad6llca_ Alpha and beta proteins (a/b) Flavodoxin-like Flavoproteins Quinone reductase NAD(P)H:quinone reductase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Bd6llcb_ Alpha and beta proteins (a/b) Flavodoxin-like Flavoproteins Quinone reductase NAD(P)H:quinone reductase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Cd6llcc_ Alpha and beta proteins (a/b) Flavodoxin-like Flavoproteins Quinone reductase NAD(P)H:quinone reductase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Dd6llcd_ Alpha and beta proteins (a/b) Flavodoxin-like Flavoproteins Quinone reductase NAD(P)H:quinone reductase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Ed6llce_ Alpha and beta proteins (a/b) Flavodoxin-like Flavoproteins Quinone reductase NAD(P)H:quinone reductase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Fd6llcf_ Alpha and beta proteins (a/b) Flavodoxin-like Flavoproteins Quinone reductase NAD(P)H:quinone reductase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Gd6llcg_ Alpha and beta proteins (a/b) Flavodoxin-like Flavoproteins Quinone reductase NAD(P)H:quinone reductase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Hd6llch_ Alpha and beta proteins (a/b) Flavodoxin-like Flavoproteins Quinone reductase NAD(P)H:quinone reductase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Id6llci_ Alpha and beta proteins (a/b) Flavodoxin-like Flavoproteins Quinone reductase NAD(P)H:quinone reductase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Jd6llcj_ Alpha and beta proteins (a/b) Flavodoxin-like Flavoproteins Quinone reductase NAD(P)H:quinone reductase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Kd6llck_ Alpha and beta proteins (a/b) Flavodoxin-like Flavoproteins Quinone reductase NAD(P)H:quinone reductase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Ld6llcl_ Alpha and beta proteins (a/b) Flavodoxin-like Flavoproteins Quinone reductase NAD(P)H:quinone reductase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyFlavoproteins 8044090 3001217 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyFlavoproteins 8044090 3001217 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyFlavoproteins 8044090 3001217 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyFlavoproteins 8044090 3001217 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyFlavoproteins 8044090 3001217 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyFlavoproteins 8044090 3001217 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyFlavoproteins 8044090 3001217 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyFlavoproteins 8044090 3001217 SCOP2B (2022-06-29)
ISCOP2B SuperfamilyFlavoproteins 8044090 3001217 SCOP2B (2022-06-29)
JSCOP2B SuperfamilyFlavoproteins 8044090 3001217 SCOP2B (2022-06-29)
KSCOP2B SuperfamilyFlavoproteins 8044090 3001217 SCOP2B (2022-06-29)
LSCOP2B SuperfamilyFlavoproteins 8044090 3001217 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AFMN_rede6llcA1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Flavoproteins/Phosphotyrosine protein phosphatases-likeT: FlavoproteinsF: FMN_redECOD (1.6)
BFMN_rede6llcB1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Flavoproteins/Phosphotyrosine protein phosphatases-likeT: FlavoproteinsF: FMN_redECOD (1.6)
CFMN_rede6llcC1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Flavoproteins/Phosphotyrosine protein phosphatases-likeT: FlavoproteinsF: FMN_redECOD (1.6)
DFMN_rede6llcD1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Flavoproteins/Phosphotyrosine protein phosphatases-likeT: FlavoproteinsF: FMN_redECOD (1.6)
EFMN_rede6llcE1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Flavoproteins/Phosphotyrosine protein phosphatases-likeT: FlavoproteinsF: FMN_redECOD (1.6)
FFMN_rede6llcF1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Flavoproteins/Phosphotyrosine protein phosphatases-likeT: FlavoproteinsF: FMN_redECOD (1.6)
GFMN_rede6llcG1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Flavoproteins/Phosphotyrosine protein phosphatases-likeT: FlavoproteinsF: FMN_redECOD (1.6)
HFMN_rede6llcH1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Flavoproteins/Phosphotyrosine protein phosphatases-likeT: FlavoproteinsF: FMN_redECOD (1.6)
IFMN_rede6llcI1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Flavoproteins/Phosphotyrosine protein phosphatases-likeT: FlavoproteinsF: FMN_redECOD (1.6)
JFMN_rede6llcJ1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Flavoproteins/Phosphotyrosine protein phosphatases-likeT: FlavoproteinsF: FMN_redECOD (1.6)
KFMN_rede6llcK1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Flavoproteins/Phosphotyrosine protein phosphatases-likeT: FlavoproteinsF: FMN_redECOD (1.6)
LFMN_rede6llcL1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Flavoproteins/Phosphotyrosine protein phosphatases-likeT: FlavoproteinsF: FMN_redECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF02525Flavodoxin-like fold (Flavodoxin_2)Flavodoxin-like foldThis family consists of a domain with a flavodoxin-like fold. The family includes bacterial and eukaryotic NAD(P)H dehydrogenase (quinone) EC:1.6.99.2. These enzymes catalyse the NAD(P)H-dependent two-electron reductions of quinones and protect cell ...This family consists of a domain with a flavodoxin-like fold. The family includes bacterial and eukaryotic NAD(P)H dehydrogenase (quinone) EC:1.6.99.2. These enzymes catalyse the NAD(P)H-dependent two-electron reductions of quinones and protect cells against damage by free radicals and reactive oxygen species [1]. This enzyme uses a FAD co-factor. The equation for this reaction is:- NAD(P)H + acceptor <=> NAD(P)(+) + reduced acceptor. This enzyme is also involved in the bioactivation of prodrugs used in chemotherapy [1]. The family also includes acyl carrier protein phosphodiesterase EC:3.1.4.14. This enzyme converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine residue from ACP [2]. This family is related to Pfam:PF03358 and Pfam:PF00258.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D, E
NAD(P)H dehydrogenase [quinone] 1

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C, D, E
IPR003680Flavodoxin-like foldDomain
A, B, C, D, E
IPR029039Flavoprotein-like superfamilyHomologous Superfamily
A, B, C, D, E
IPR051545NAD(P)H dehydrogenase (quinone)Family

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A, B, C, D, E
PharosP15559