Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AAntibiotic_NATe6mn3A1 A: a/b three-layered sandwichesX: Hypothetical protein TT1679 (From Topology)H: Hypothetical protein TT1679 (From Topology)T: Hypothetical protein TT1679F: Antibiotic_NATECOD (1.6)
BAntibiotic_NATe6mn3B1 A: a/b three-layered sandwichesX: Hypothetical protein TT1679 (From Topology)H: Hypothetical protein TT1679 (From Topology)T: Hypothetical protein TT1679F: Antibiotic_NATECOD (1.6)

AMR Gene: CARD Annotation CARD Database Homepage

ChainsAccessionShort NameDescriptionProvenance Source (Version)
A, B
ARO:3002539AAC(3)-IVaAAC(3)-IV is a plasmid-encoded aminoglycoside acetyltransferase in E. coli, C. jejuni and P. stutzeri.CARD (3.3.0)

AMR Gene Family: CARD Annotation CARD Database Homepage

ChainsAccessionGene FamilyDrug Class Resistance MachanismProvenance Source (Version)
A, B
ARO:3000322AAC(3)aminoglycoside antibioticantibiotic inactivationCARD (3.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF02522Aminoglycoside 3-N-acetyltransferase (Antibiotic_NAT)Aminoglycoside 3-N-acetyltransferaseThis family consists of bacterial aminoglycoside 3-N-acetyltransferases EC:2.3.1.81, these catalyse the reaction: Acetyl-Co + a 2-deoxystreptamine antibiotic <=> CoA + N3'-acetyl-2-deoxystreptamine antibiotic. The enzyme can use ...This family consists of bacterial aminoglycoside 3-N-acetyltransferases EC:2.3.1.81, these catalyse the reaction: Acetyl-Co + a 2-deoxystreptamine antibiotic <=> CoA + N3'-acetyl-2-deoxystreptamine antibiotic. The enzyme can use a range of antibiotics with 2-deoxystreptamine rings as acceptor for its acetyltransferase activity, this inactivates and confers resistance to gentamicin, kanamycin, tobramycin, neomycin and apramycin amongst others.
Domain

InterPro: Protein Family Classification InterPro Database Homepage