Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AACPSe6rcxA2 A: a+b three layersX: Bacillus chorismate mutase-likeH: 4'-phosphopantetheinyl transferase (From Topology)T: 4'-phosphopantetheinyl transferaseF: ACPSECOD (1.6)
AEntDe6rcxA1 A: a+b three layersX: Bacillus chorismate mutase-likeH: 4'-phosphopantetheinyl transferase (From Topology)T: 4'-phosphopantetheinyl transferaseF: EntDECOD (1.6)
BPP-bindinge6rcxB1 A: alpha bundlesX: ACP-likeH: Acyl-carrier protein (ACP) (From Topology)T: Acyl-carrier protein (ACP)F: PP-bindingECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF178374'-phosphopantetheinyl transferase N-terminal domain (4PPT_N)4'-phosphopantetheinyl transferase N-terminal domainThis entry represents the N-terminal domain from 4'- phosphopantetheinyl transferase enzymes. This domain is structurally related to the Pfam:PF01648 domain with which it forms a pseudodimeric arrangement [2].Domain
PF016484'-phosphopantetheinyl transferase superfamily (ACPS)4'-phosphopantetheinyl transferase superfamilyMembers of this family transfers the 4'-phosphopantetheine (4'-PP) moiety from coenzyme A (CoA) to the invariant serine of Pfam:PF00550. This post-translational modification renders holo-ACP capable of acyl group activation via thioesterification of ...Members of this family transfers the 4'-phosphopantetheine (4'-PP) moiety from coenzyme A (CoA) to the invariant serine of Pfam:PF00550. This post-translational modification renders holo-ACP capable of acyl group activation via thioesterification of the cysteamine thiol of 4'-PP [1]. This superfamily consists of two subtypes: The ACPS type such as Swiss:P24224 and the Sfp type such as Swiss:P39135. The structure of the Sfp type is known [3], which shows the active site accommodates a magnesium ion. The most highly conserved regions of the alignment are involved in binding the magnesium ion.
Domain
PF00550Phosphopantetheine attachment site (PP-binding)Phosphopantetheine attachment siteA 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes memb ...A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Possible 4'-phosphopantetheinyl transferase
Phthiocerol synthesis polyketide synthase type I PpsC

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR0371434'-phosphopantetheinyl transferase domain superfamilyHomologous Superfamily
IPR003542Enterobactin synthetase-like, component DFamily
IPR0413544'-phosphopantetheinyl transferase, N-terminal domainDomain
IPR0082784'-phosphopantetheinyl transferase domainDomain
IPR016035Acyl transferase/acyl hydrolase/lysophospholipaseHomologous Superfamily
IPR014031Beta-ketoacyl synthase, C-terminalDomain
IPR006162Phosphopantetheine attachment sitePTM
IPR013154Alcohol dehydrogenase-like, N-terminalDomain
IPR020807Polyketide synthase, dehydratase domainDomain
IPR049552Polyketide synthase, dehydratase domain, N-terminalDomain
IPR049551Polyketide synthase, dehydratase domain, C-terminalDomain
IPR020843Polyketide synthase, enoylreductase domainDomain
IPR013968Polyketide synthase, ketoreductase domainDomain
IPR016036Malonyl-CoA ACP transacylase, ACP-bindingHomologous Superfamily
IPR050091Polyketide and Nonribosomal Peptide Biosynthesis EnzymesFamily
IPR020806Polyketide synthase, phosphopantetheine-binding domainDomain
IPR020841Polyketide synthase, beta-ketoacyl synthase domainDomain
IPR036736ACP-like superfamilyHomologous Superfamily
IPR014043Acyl transferase domainDomain
IPR011032GroES-like superfamilyHomologous Superfamily
IPR009081Phosphopantetheine binding ACP domainDomain
IPR016039Thiolase-likeHomologous Superfamily
IPR001227Acyl transferase domain superfamilyHomologous Superfamily
IPR036291NAD(P)-binding domain superfamilyHomologous Superfamily
IPR018201Beta-ketoacyl synthase, active siteActive Site
IPR014030Beta-ketoacyl synthase-like, N-terminalDomain
IPR042104Polyketide synthase, dehydratase domain superfamilyHomologous Superfamily
IPR049900Polyketide/metazoan fatty acid synthase, dehydratase domainDomain