Annotations: 6S22

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Ricin_B_lectin	e6s22A2	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: Ricin_B_lectin	ECOD (1.6)
A	Glycos_transf_2	e6s22A1	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: Glycos_transf_2	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00535	Glycosyl transferase family 2 (Glycos_transf_2)	Glycosyl transferase family 2	-	Family
A	PF00652	Ricin-type beta-trefoil lectin domain (Ricin_B_lectin)	Ricin-type beta-trefoil lectin domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B [auth F]	Fibroblast growth factor 23	protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity fibroblast growth factor receptor binding growth factor receptor binding type 1 fibroblast growth factor receptor binding	phosphate ion homeostasis intracellular phosphate ion homeostasis cellular homeostasis inorganic ion homeostasis chemical homeostasis homeostatic process intracellular chemical homeostasis developmental process cellular developmental process cell differentiation cellular process regulation of localization localization regulation of biological process phosphate ion homeostasis intracellular phosphate ion homeostasis cellular homeostasis inorganic ion homeostasis chemical homeostasis homeostatic process intracellular chemical homeostasis developmental process cellular developmental process cell differentiation cellular process regulation of localization localization regulation of biological process regulation of transport transport biological regulation phosphate ion transport regulation of phosphate transport establishment of localization inorganic anion transport anatomical structure morphogenesis animal organ development anatomical structure development animal organ morphogenesis cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of cellular process regulation of signaling positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade regulation of cell communication ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of signaling regulation of biosynthetic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process metabolic process positive regulation of macromolecule metabolic process macromolecule metabolic process regulation of metabolic process regulation of osteoblast differentiation multicellular organismal process regulation of developmental process negative regulation of osteoblast differentiation negative regulation of developmental process negative regulation of biological process regulation of cell differentiation osteoblast differentiation ossification negative regulation of cellular process negative regulation of cell differentiation regulation of hormone secretion negative regulation of signaling negative regulation of transport hormone secretion negative regulation of cell communication negative regulation of secretion regulation of secretion by cell secretion by cell signal release negative regulation of hormone secretion negative regulation of secretion by cell regulation of biological quality secretion regulation of hormone levels export from cell cell-cell signaling regulation of secretion hormone transport regulation of cell motility regulation of locomotion regulation of cell migration cell migration cell motility locomotion response to nutrient levels response to lipid response to nutrient cellular response to organic cyclic compound response to oxygen-containing compound response to vitamin cellular response to oxygen-containing compound cellular response to vitamin D cellular response to nutrient levels cellular response to chemical stimulus response to vitamin D cellular response to vitamin response to chemical cellular response to lipid cellular response to nutrient response to organic cyclic compound catabolic process lipid catabolic process fat-soluble vitamin metabolic process organic hydroxy compound metabolic process steroid metabolic process vitamin D catabolic process primary metabolic process vitamin D metabolic process fat-soluble vitamin catabolic process vitamin catabolic process vitamin metabolic process steroid catabolic process organic hydroxy compound catabolic process small molecule metabolic process small molecule catabolic process lipid metabolic process cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation positive regulation of vitamin D 24-hydroxylase activity regulation of catalytic activity positive regulation of catalytic activity regulation of oxidoreductase activity positive regulation of oxidoreductase activity regulation of molecular function positive regulation of molecular function regulation of monooxygenase activity positive regulation of monooxygenase activity regulation of vitamin D 24-hydroxylase activity response to fibroblast growth factor cellular response to growth factor stimulus cell surface receptor protein tyrosine kinase signaling pathway cellular response to endogenous stimulus enzyme-linked receptor protein signaling pathway positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway cell surface receptor signaling pathway response to endogenous stimulus fibroblast growth factor receptor signaling pathway response to growth factor cellular response to fibroblast growth factor stimulus cellular response to leptin stimulus response to hormone response to leptin cellular response to hormone stimulus response to peptide response to interleukin-6 cellular response to interleukin-6 response to cytokine cellular response to cytokine stimulus monoatomic ion homeostasis calcium ion homeostasis monoatomic cation homeostasis cellular response to parathyroid hormone stimulus response to parathyroid hormone positive regulation of DNA-templated transcription RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process positive regulation of nucleobase-containing compound metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of phosphate metabolic process positive regulation of protein modification process regulation of phosphate metabolic process phosphate-containing compound metabolic process protein metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process macromolecule modification regulation of phosphorus metabolic process regulation of phosphorylation response to sodium phosphate response to salt negative regulation of biomineral tissue development regulation of biomineral tissue development regulation of bone mineralization negative regulation of bone mineralization multicellular organism development biomineral tissue development regulation of multicellular organismal process regulation of multicellular organismal development bone mineralization tissue development negative regulation of ossification negative regulation of multicellular organismal process regulation of ossification response to metal ion response to magnesium ion	cellular anatomical structure intracellular anatomical structure cytoplasm membrane-bounded organelle Golgi apparatus membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen Golgi lumen intracellular organelle organelle lumen organelle endoplasmic reticulum lumen cellular anatomical structure intracellular anatomical structure cytoplasm membrane-bounded organelle Golgi apparatus membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen Golgi lumen intracellular organelle organelle lumen organelle endoplasmic reticulum lumen endoplasmic reticulum extracellular region extracellular space
A	Polypeptide N-acetylgalactosaminyltransferase	binding carbohydrate binding cation binding manganese ion binding transition metal ion binding ion binding metal ion binding small molecule binding UDP-glycosyltransferase activity polypeptide N-acetylgalactosaminyltransferase activity catalytic activity, acting on a protein glycosyltransferase activity transferase activity acetylgalactosaminyltransferase activity binding carbohydrate binding cation binding manganese ion binding transition metal ion binding ion binding metal ion binding small molecule binding UDP-glycosyltransferase activity polypeptide N-acetylgalactosaminyltransferase activity catalytic activity, acting on a protein glycosyltransferase activity transferase activity acetylgalactosaminyltransferase activity hexosyltransferase activity catalytic activity	carbohydrate derivative biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein glycosylation macromolecule biosynthetic process biosynthetic process glycosylation macromolecule modification macromolecule glycosylation protein O-linked glycosylation peptidyl-amino acid modification metabolic process carbohydrate derivative biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein glycosylation macromolecule biosynthetic process biosynthetic process glycosylation macromolecule modification macromolecule glycosylation protein O-linked glycosylation peptidyl-amino acid modification metabolic process cellular process protein metabolic process macromolecule metabolic process peptidyl-threonine modification protein O-linked glycosylation via threonine protein modification process	membrane-bounded organelle intracellular anatomical structure Golgi cisterna membrane Golgi apparatus subcompartment Golgi apparatus organelle subcompartment membrane Golgi cisterna intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure organelle Golgi stack membrane-bounded organelle intracellular anatomical structure Golgi cisterna membrane Golgi apparatus subcompartment Golgi apparatus organelle subcompartment membrane Golgi cisterna intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure organelle Golgi stack cytoplasm organelle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B [auth F]	IPR008996	Cytokine IL1/FGF	Homologous Superfamily
B [auth F]	IPR002209	Fibroblast growth factor family	Family
A	IPR045885	N-acetylgalactosaminyltransferase	Domain
A	IPR035992	Ricin B-like lectins	Homologous Superfamily
A	IPR029044	Nucleotide-diphospho-sugar transferases	Homologous Superfamily
A	IPR001173	Glycosyltransferase 2-like	Domain
A	IPR000772	Ricin B, lectin domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B [auth F]	Pharos: Q9GZV9	autosomal dominant hypophosphatemic rickets hyperphosphatemia calcinosis familial hyperphosphatemic tumoral calcinosis/hyperphosphatemic hyperostosis syndrome osteomalacia hypophosphatemia Tumoral calcinosis X-linked dominant hypophosphatemic rickets acquired metabolic disease chronic kidney disease hyperparathyroidism hypophosphatemic rickets osteogenesis imperfecta renal osteodystrophy tumoral calcinosis, hyperphosphatemic, familial, 1 autosomal dominant hypophosphatemic rickets hyperphosphatemia calcinosis familial hyperphosphatemic tumoral calcinosis/hyperphosphatemic hyperostosis syndrome osteomalacia hypophosphatemia Tumoral calcinosis X-linked dominant hypophosphatemic rickets acquired metabolic disease chronic kidney disease hyperparathyroidism hypophosphatemic rickets osteogenesis imperfecta renal osteodystrophy tumoral calcinosis, hyperphosphatemic, familial, 1 colorectal adenoma rickets tumoral calcinosis, hyperphosphatemic, familial, 2 colorectal cancer hypercalcemia disease nephrolithiasis psoriasis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.