6Y8K

Crystal structure of CD137 in complex with the cyclic peptide BCY10916

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth AAA]	TNFR_c6	e6y8kAAA2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFR_c6	ECOD (1.6)
A [auth AAA]	TNFRSF5	e6y8kAAA1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFRSF5	ECOD (1.6)
A [auth AAA]	TNFRSF14	e6y8kAAA3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFRSF14	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth AAA]	PF00020	TNFR/NGFR cysteine-rich region (TNFR_c6)	TNFR/NGFR cysteine-rich region	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth AAA]	Tumor necrosis factor receptor superfamily member 9	molecular transducer activity signaling receptor activity	cellular process apoptotic process cell death programmed cell death negative regulation of cell population proliferation regulation of biological process cell population proliferation regulation of cellular process regulation of cell population proliferation negative regulation of cellular process biological regulation negative regulation of biological process multicellular organismal process cellular developmental process cellular process apoptotic process cell death programmed cell death negative regulation of cell population proliferation regulation of biological process cell population proliferation regulation of cellular process regulation of cell population proliferation negative regulation of cellular process biological regulation negative regulation of biological process multicellular organismal process cellular developmental process regulation of leukocyte activation immature T cell proliferation in thymus regulation of cell activation cell development mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte proliferation leukocyte activation T cell differentiation in thymus T cell activation cell differentiation lymphocyte proliferation anatomical structure development regulation of immature T cell proliferation regulation of multicellular organismal process regulation of immune system process T cell differentiation T cell proliferation regulation of lymphocyte proliferation developmental process regulation of leukocyte proliferation hemopoiesis cell activation regulation of T cell activation immature T cell proliferation regulation of immature T cell proliferation in thymus regulation of T cell proliferation mononuclear cell proliferation immune system process regulation of mononuclear cell proliferation regulation of lymphocyte activation leukocyte differentiation	cell periphery plasma membrane membrane cellular anatomical entity cell surface external side of plasma membrane side of membrane
B [auth PPP]	BCY10916	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth AAA]	IPR009030	Growth factor receptor cysteine-rich domain superfamily	Homologous Superfamily
A [auth AAA]	IPR001368	TNFR/NGFR cysteine-rich region	Domain
A [auth AAA]	IPR020413	Tumour necrosis factor receptor 9	Family
A [auth AAA]	IPR034020	Tumour necrosis factor receptor 9, N-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth AAA]	Pharos: Q07011	ulcerative colitis malignant colon neoplasm medulloblastoma tuberculosis benign colon neoplasm colorectal cancer gastric cancer hereditary diffuse gastric adenocarcinoma kidney cancer lung cancer Malignant neoplasm of kidney psoriasis cancer Crohn disease gastric neoplasm ulcerative colitis malignant colon neoplasm medulloblastoma tuberculosis benign colon neoplasm colorectal cancer gastric cancer hereditary diffuse gastric adenocarcinoma kidney cancer lung cancer Malignant neoplasm of kidney psoriasis cancer Crohn disease gastric neoplasm inflammatory bowel disease kidney neoplasm lymphatic system disease rheumatoid arthritis colonic neoplasm cutaneous lupus erythematosus hematologic disease interstitial cystitis lung adenocarcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.